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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder ari piperazinyl phenyl urea ane chimiro rakasiyana alkyl carbamates Alpha-keto heterocyclic yeimwe uye ane simba uye kusarudza inhibitor kuti mafuta iine acid amide hydrolase (FAAH) (IC50s = 34 uye 33 NM mu gonzo uye munhu ukuwo) kuti anokwanisa kuyambuka ropa-uropi hwomumakumbo.1 Pa 20 mg / kg, inosungirirana yakavhara kunzvimbo inoshandiswa ye FAAH kuburikidza nekujekesa kwemabasa eurea anoita aniline uye FAAH-poperazinyl carbamate.

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Product Description

 

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video

 

 


 

I.N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters:

 

Name: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Kuchena: ≥99% (HPLC)
Synonyms: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Molecular Formula: C19H19N5OS
Molecular Weight: 365.459
Nheyo yakanyunguduka: 240.48
Dhikirai: 559.69 ° C pa 760 mmHg
Kuwandisa: ~ 1.3 g / cm3
Storage Temp: Chengeta pa + 4 ° C
Solubility: DMSO: ≥28mg / mL
Refractive index: n20D 1.68
Color: A crystalline yakasimba
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChI Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N

 


 

II. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Kushandiswa kwepodha mumhepo:

1.Name:

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid upfu, JNJ 166101 Powder

2.How ndiro basa musi N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid powder kushandiswa?

FAAH preincubated pamwe JNJ1661010 rinoratidza kunonoka reversibility ari kudyidzana pakati JNJ1661010 uye kushingaira nzvimbo, iyo nokukurumidza pana kukwira. JNJ-1661010 inofanana, inogadziriswa-substrate inhibitor yakaongororwa naLC-ESI-MS. JNJ-1661010 nechiteshi chengarava pamwe phenylthiadiazole ari hydrophobic mugero uye phenylurea iri hydrophilic muhomwe FAAH, JNJ-1661010 (20 MG / makirogiramu Rinozvikudza ip) kuchititadzisa FAAH kubudikidza anenge 85% kusvika 4 H pashure dosing, zvichiita kuunganidza lipid ethanolamides muhuropi hwechikwata. JNJ-1661010 dose-dependently kudzokera kuti tactile allodynia ane kunonyanyisa efficacy kweinenge 90% pa 30 Maminitsi postdose zvose Nounyoro Thermal Injury (MTI) makonzo uye gonzo womuenzaniso. JNJ-1661010 (20 mg / kg) inodzokorora tactile allodynia ne 60.8% pa 30 min mukoko yepal spinal nerve ligation yokukuvadza. JNJ-1661010 (50 MG / makirogiramu Rinozvikudza ip) inoratidza chinokosha attenuation pamusoro hyperalgesia pana 30 Maminitsi postdose mu gonzo carrageenan muenzaniso anogumbura marwadzo.
Makonzo dosed pamwe JNJ-1661010 (20 MG / makirogiramu Rinozvikudza ip) ane yeplasma Cmax pamusoro 26.9 μM panguva Tmax pamusoro 0.75 H uye Cmax mu uropi 6.04 μM panguva Tmax pamusoro 2 h. JNJ-1661010 (20 mg / kg ip) inhibitsvo uropi FAAH uye inosimudza chiyero cheAEA mumakumbo europi mumakonzo.

3.Zvava pamusoro peN-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid powder

4.kuwedzera mirayiridzo:

5. N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder:

Min order 10grams.
Inobvunza pamusoro pezvakawanda (mukati 1kg) inogona kutumirwa mumaawa e12 mushure mekubhadhara.
Kuti uve mukuru (mukati 1kg) inogona kutumirwa muC3 kushanda kwemashure mushure mekubhadhara.

6. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Powder Recipes:

Kubvunzurudza Mutengi wedu Mumiririri (CSR) nezvemashoko, nekuda kwako.

7. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid powder Marketing:

Kuti igoverwe mune ramangwana riri mberi.

 


 

III. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide powder HNMR

 

Isu Aprepitant powder supplie, Aprepitant poda yekutengesa, Raw Aprepitant powder (170729-80-3) hplc =98% | Yakarura R & D Reagents

 


 

IV. How kutenga N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide upfu kubva AASraw?

 

1.Kutaurirana nesu ne email yedumvumo yekubvunzurudza, kana kuti inotenga skypeMutariri wevashandi (CSR).
2.Kutipa isu yakabvunzwa nekero.
3.Our CSR ichakupa iyo quotation, nguva yekubhadhara, nhamba yekutsvaga, nzira yekuendesa uye inofungidzirwa zuva rekuuya (ETA).
4.Payment yakaitwa uye zvigadzirwa zvichaendeswa mumaawa e12 (Kurongeka mukati me10kg).
5.Goods inogamuchira uye inopa mhinduro.

 


 

Fungidzira zvaunoda chigadzirwa blog:

 

 Mukadzi Mukadzi Anorwara? Zvose pamusoro peBonde Kuwedzera Flibanserin powder Nzira yekushandisa nayo Clenbuterol kuti uwedzere kurasikirwa Chii chinonzi nandrolone poda yakashandiswa / nandrolone inobatsira?

 


 

Zvimwe tsanangudzo pamusoro pezvinhu zvakakosha zvemiti,gamuchirai kuti munyore pano.


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