Nokuti mamwe mapeji akashandurwa ne software uye haana kunyatsokwana, tapota edza kuongorora iyo en Chirungu maonero ezvinyorwa zviri nani.

JW 642

Endocannabinoids yakadai se2-arachidonoyl glycerol (2-AG) uye arachidonoyl ethanolamide inoshandiswa muhupenyu hunoita zvirongwa zvinosanganisira maitiro akawanda emasikirati anosanganisira kushandiswa kwezvinogamuchirwa zvinokonzerwa ne cannabinoid. JW 642 ndiyo inhibitor yakasimba ye monoacylglycerol lipase (MAGL) iyo inoratidza IC50 tsika dze 7.6, 14, uye 3.7 nM kuregererwa kweM MAGL mumushonga, purogiramu, uye hutachiona hwehuropi hwevanhu, zvichienderana. JW642is inosarudza MAGL, inoda zvikamu zvakakwirira zvakanyanya kuti zvidzivirire mafuta mafuta asidi amide hydrolase (IC50s = 31, 14, uye 20.6 μM nokuda kwemushonga, rati, uye hutachiona hwehuropi hunopfurikidza, zvichienderana).

Product Description

 

JW 642 video

 

 


 

I.JW 642 Basic Characters:

 

Name: JW 642
CAS: 1416133-89-5
Molecular Formula: C21H20F6N2O3
Molecular Weight: 462.4
Melt Point:
Storage Temp: pa -20 ° C 3 makore Poda
Color: Yakachena yakasimba

 


 

II. JW 642 purogiramu

 

1. Mazita:

Makemikari Mazita:
4 - [(3-Phenoxyphenyl) methyl] -1-piperazinecarboxylic acid 2,2,2-trifluoro-1- (trifluoromethyl) ethyl ester
Synonyms:
JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate

 

2. JW 642 Kushandisa:

Mune maitiro e laboratori, kwenguva refu yekuchengetedza, tinopa kuti JW 642be yakachengetwa yakasimbiswa pa -20 ℃. Inofanira kuva yakasimba kune gore rimwechete.
JW 642 inopiwa semhinduro mune methyl acetate. Kuti uchinje saridho, ingobuda mhepo ye methyl acetate pasi pegorova rwizi rwe nitrogen uye pakarepo kuwedzera sarudzo yekusarudza. Mafuta ane asethanol akadaro, DMSO, uye dimethyl formamide yakacheneswa negesi inert ingashandiswa. Iyo inogadziriswa yeJW 642 mune izvi zvinokwana 13,5, uye 11mg / ml, maererano.
JW 642 iri zvishoma nezvishoma inogadziriswa mumagetsi anonyanyisa. Nokuda kwehuwandu hwekushongedzerwa mune aqueousbuffers, iyo yeiyanano sarudzo yeJW 642ku inofanira kudimbiswa pamwe nechepamusoro-soro chechigamba. JW 642 ine sarubility inenge ye0.3 mg / ml mune 1: 2 solution ye ethanol: PBS (pH 7.2) uchishandisa iyi nzira. Hatinokurudzira kuchengetedza mhinduro yakasimba kwemazuva anopfuura.

 

3.Chii chiyero cheJW 642?

DMSO ku 100 mM
Ethanol ku 100 mM
Zano rakagadzikana uye Inogadziriswa: Zvimwe zvinogadzirisa zvinogona kuva zvakaoma kuwana uye zvinogona kukurudzirwa nekukurumidza, kushandura kana kuchenesa (mune 45-60 ° C mumvura yekushambidza mvura). Mashoko ane chokuita nekugadzikana kwechigadzirwa, kunyanya mukugadzirisa, haasati ataurwa uye munguva dzakawanda tinogona kungopa mutungamiri mukuru. Mazano edu anowanikwa ndeokuti: SOLIDS: Yakapiwa kuchengetedza yakataurwa pane zvakashambadzira uye chidimbu chinoramba chakaiswa chisimbiso, chigadzirwa chacho chinogona kuchengetwa kusvika pamwedzi we6 kubva pazuva rawakagamuchira. SOLUTIONS: Tinokurudzira kuti mishonga yekugadzirisa, iyo yakagadzirirwa, inochengetwa yakagadzirirwa zvakasimba muchisimbiso vialsat -20 ° C kana pasi uye inoshandiswa mukati memwedzi we1. Pose pane zvigadziriswa zvinogadziriswa zvinofanira kuitwa uye kushandiswa pazuva rimwechete.

 

4.How JW 642 inoshanda?

JW 642 isimba uye inosarudza monoacylglycerol lipase (MAGL) inhibitor (IC = 3.7 nM). Zviratidzo> 1000-fold selectivity ye MAGL pamusoro pemafuta asidi amidehydrolase (IC = 20.6 μM). Monoacylglycerol lipase (MAGL) isa serine hydrolase inotungamirira hydrolysis ya 2-AG kune arachidonic acid uye glycerol, nokudaro kupedza basa rayo. Zvinokonzerwa nehutachiona zvinogona kukonzerwa sezasi: Methyl Acetate - Dhiyabhorosi Data: Oral LD50 (rat):> 5,000 mg / kg; Muromo LD50 (mbira): 3,705 mg / kg; Ganda LD50 (mbira):> 5,000 mg / kg; Inhalation TCLO (munhu): 15,000 mg / m3; Methyl Acetate - Irritation Data: Ganda (rabbit): 500 mg (24h) munyoro; Maziso (musuru): 100 mg (24h) inonyoresa.

 

5.Zvava:

I.Kunyatsogadzirisa uye kugadzirisa

5.1 Reactivity

Yakagadzika pasi pekurudzirwa kutakura kana kuchengetedza mamiriro.

5.2 Chimiro chigadzikane

Yakasimba pasi pekuchengetedzwa kwekuchengetedzwa kwemamiriro.

5.3 Kusava nekukanganisa kwakaipisisa

Kukanganisa kwakaipisisa hakuzoitiki pasi pekutakura kwekutakura kana kuchengetedza mamiriro. Kuparara kunogona kuitika pazvinenge zvichienderana nemamiriro ezvinhu kana zvinhu zvakanyorwa pasi apa.

5.4 Mamiriro ezvinhu ekudzivirira kupisa, unyoro.
5.5 Zvinhu zvisingaenderani

Simba reAicid / alkalis, strong oxidising / reductor agents.

5.6 Kuora kwezvinhu zvinokuvadza

Mukuvhenekera kunogona kubudisa mafungu anotyisa. Hapana zivo inozivikanwa yokuparara.

II.Handing uye kuchengetedza

5.1 Kuchengetedzwa kwekuchengetedza kwakachengeteka

Shandisa mune imwe makemikari fume hood, nemhepo inopiwa nehurumende yakasununguka. Dzivisa kuputika, kusangana nemaziso, ganda uye
nguo. Dzivisa kuumbwa kweguruva nemafuta. Shandisa munzvimbo yakanaka yemhepo. Chengetedza kure nemagetsi ekudzima. Dzivisa
kuramba kwenguva refu kana kuti kudzokorora.

5.2 Zvigaro zvekuchengetedzwa kwakachengeteka, kusanganisira chero zvisingabvumirwi.

Chengetedza munzvimbo inotonhorera, yakanyatsonaka. Ramba uri kure nezuva rakananga. Chengetedza mudziyo wakanyatsoiswa chisimbiso kusvikira wakagadzirira kushandiswa.
Yakakurudzirwa kutonhora kwekuchengetedza: Chengeta pa -20 ° C

5.3 Kugumira kunoshandiswa kunoshandiswa

Shandisa mune hoodary fume hood kana zvichibvira.

 

6.JW 642 Mushonga Wakawanda:

Min order 10grams.
Inobvunza pamusoro pezvakawanda (mukati 1kg) inogona kutumirwa mumaawa e12 mushure mekubhadhara.
Kuti uwedzere kurongeka kunogona kutumirwa mumazuva ekushanda kwe3 mushure mekubhadhara.

 

7.JW 642 Raw Powder Recipes:

Kubvunzurudza Mutengi wedu Mumiririri (CSR) nezvemashoko, nekuda kwako.

 

8.JW 642 Marketing:

Kuti igoverwe mune ramangwana riri mberi.

 

9.Does JW 642 Ane Mhinduro Dzakashata Here?

Zvinyorwa zvingave zvinogumbura kumuchere membrane nepamusoro chekufema mukati; Inogona kunge inokuvadza nekuputika, kuisa, kana kugunzva ganda; Inogona kukonzera kugona usingadi; Inogona kukonzera ganda kana kupumhidza kushungurudza. Kudzokorora kunogona kukonzera ganda rikaoma kana kuputika.
Kudzora kutonga / kuchengetedzwa kwemunhu

9.1 Kudzora mararamiro

Zvinokonzerwa nebasa rekugadzirisa zvirongwa
Haina zvinhu izvo zvinokonzerwa nemiganhu yekuzvidzivirira.

9.2 Kudzora mamiriro ekudzivirira

Zvakakodzera maune engineering controls
Shandisa muhombe yefume iyo inoshanda. Iva nechokwadi kuti zviyero zveunyanzvi zvinorondedzerwa pasi pechikamu 7 zve SDS zviri munzvimbo.
Iva nechokwadi kuti laboratori yakagadzirirwa nekuchengetedzwa kwezvokuchengetedza uye nzvimbo yekuisa maziso.
Zvishandiso zvemunhu oga

Ziso / zviso zvekudzivirira
Shandisa magirazi akachengeteka akakodzera.
Kuchengetedzwa kweganda
Shandisa zvakakodzera makemikari asingadziviriki (gadziriro inoshandiswa kushandisa standard BS EN 374: 2003). Magirafu anofanirwa kuva
akaongororwa asati ashandiswa. Shamba uye uomesa maoko zvakakwana mushure mokubata.
Mutumbi kudzivirirwa
Kupfeka zvipfeko zvakakodzera zvokudzivirira.
Kudzivirira kupora
Kana kuongororwa kwengozi kuchiratidza kudiwa, shandisa mhepo yakakodzera.

al pakati pevamwe

 


 

III. JW 642 HNMR

 

Isu Aprepitant powder supplie, Aprepitant poda yekutengesa, Raw Aprepitant powder (170729-80-3) hplc =98% | Yakarura R & D Reagents

 


 

IV. Nzira yekutenga JW 642 kubva paAASraw?

 

1.Kutaurirana nesu ne email yedumvumo yekubvunzurudza, kana kuti inotenga skypeMutariri wevashandi (CSR).
2.Kutipa isu yakabvunzwa nekero.
3.Our CSR ichakupa iyo quotation, nguva yekubhadhara, nhamba yekutsvaga, nzira yekuendesa uye inofungidzirwa zuva rekuuya (ETA).
4.Payment yakaitwa uye zvigadzirwa zvichaendeswa mumaawa e12 (Kurongeka mukati me10kg).
5.Goods inogamuchira uye inopa mhinduro.

 


 

Fungidzira zvaunoda chigadzirwa blog:

 

 Mukadzi Mukadzi Anorwara? Zvose pamusoro peBonde Kuwedzera Flibanserin powder Nzira yekushandisa nayo Clenbuterol kuti uwedzere kurasikirwa Chii chinonzi nandrolone poda yakashandiswa / nandrolone inobatsira?

 


 

Zvimwe tsanangudzo pamusoro pezvinhu zvakakosha zvemiti,gamuchirai kuti munyore pano.


=

Reviews

Hapana wongororo asi.

Iva wokutanga kuongorora "JW 642"

Your kero e haangazozikamwi ichibudiswa. Raida minda anozivikanwa *

CAPTCHA *