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Nicotinamide Mononucleotide NMN

 

  1. Chii chinonzi NMN Powder?
  2. Chii chinonzi NAD + chine chekuita neNMN?
  3. Iko NMN Powder Yakachengeteka Zvinowedzera here?
  4. Ndeapi Makomborero Anogona Kuunzwa neNNN Powder kuMuviri Wangu?
  5. Ini Ndinogona Kuwana Yakaringana NMN Kubva Kudya Ku Anti-Kukwegura?
  6. Ungatora Sei NMN Powder?
  7. Ini ndinofanira kutora zvimwe zvinowedzera neNMN pamwechete?
  8. Iko NMN Yakanaka Inobatsira Pakurwisa COVID-2019?
  9. NMN VS. NR: Ndeupi Ari Nani?
  10. Ndingaite Sei Kuti Ndiwane Iyo Yakanyanya NMN Powder?
  11. Nzira Yokuchengetedza Sei NMN Powder?
  12. Iko Kune Iko Chero Chaicho Ongororo paNMN Powder?
  13. pfupiso

 

Sezvo isu tese tichiziva, Anti-kuchembera zvigadzirwa inyaya isingagumi uye vanhu vazhinji vanodzidza munda uyu kwenguva yakareba, At 2018, kune mishonga mitsva yekurwisa kuchembera uye yakakonzera kupenga pazvinhu zvinopesana nekukwegura, ichi chigadzirwa chitsva chinonzi " NMN ”. NMN (β-Nicotinamide Mononucleotide) senge nyowani mhando yezvinhu zvinopesana nekukwegura zvinozivikanwa. Kutora NMN zvinowedzera kana kuwedzera imwe poda yeNMN muchikafu chamangwanani zvakajairika kuona zvinhu kubvira 2020. Ruzivoi rwatinofanira kuziva nezveNMN uye nekutenga NMN upfu online, mibvunzo yese ine chekuita nevanhu vazhinji vakagadzirira kushandisa NMN poda kana zvinowedzera. Nhasi, taunganidza misoro yakanyanya kukurukurwa online kubva kuReddit uye quora paNMN, ndinovimba mhinduro idzi dzinogona kukubatsira iwe kuziva NMN uye kutenga yechokwadi NMN powder online.

 

Chii chinonzi NMN Powder? 

NMN ipfupi kune nicotinamide mononucleotide (CAS: 1094-61-7), iyo inowanzoitika mamorekuru aripo mune ese marudzi. Pamu molecular level, iri ribonucleotide, chinhu chakakosha chimiro chenyukisi acid RNA. Mune fomu inoumbwa neboka reNicotinamide, ribose neboka re phosphate. NMN inogadzirwa neVitamin B3 (niacin). Izvo zvinoitika zvakasikwa uye zvinogona kugadzirwa kubva kune zvekudya sosi semichero, mukaka, uye miriwo. Mumumuviri, NMN inoshandiswa kugadzira nicotinamide adenine dinucleotide (NAD +), yakasimba uye yakakosha mamorekuru inowanikwa mune yese sero yemuviri. Nekudaro, Kutora NMN upfu ndiyo imwe nzira iyo madanho eNAD + muchitokisi anogona kuwedzerwa, wozadzisa chinangwa chekurwisa-kuchembera.

Parizvino, pane nzira dzinoverengeka dzekugadzira zvigadzirwa zveNMN mufekitori, inonziwo NMN upfu. Sekuziva kwangu, ndaziva nzira mbiri kubva kufekitori inogadzira NMN upfu:

Maitiro 1 ekugadzira NMN upfu: Catalyst nzira (Industrial Giredhi)

Ichi chigadzirwa chakagadzirwa chete cheindasitiri yemakemikari maitiro ekushandisa, isina kukodzera munhu, ivo havazodi kuona inorema simbi, microbiological chiratidzo mukati mehupfu, zvine njodzi.

Maitiro 2 ekugadzira NMN upfu: Enzymatic nzira (Chikafu cheGiredhi)

Nenzira iyi, iyo NMN upfu yakachengeteka kuti vanhu vashandise, uye hapana Reagent masara, kunyangwe shandisa yekunze nzira yakajairwa kuyedza iwo mhando, mhedzisiro ichiri isingasviki 98% kuchena. . .

MUTSVENE unogadzira fekitori kugadzira NMN upfu muChina uye ndeipi nzira yataishandisa ndiyo enzymatic nzira, yega yega batch NMN poda ichaedzwa isati yatengeswa uye kuchena kunoratidza 99% min, hunhu hwakagadzikana. Takaita zvibvumirano nekambani dzinoverengeka hombe dzekuwedzera uye tinopa hupfu hweNMN kwavari kwenguva refu. Hapana mubvunzo kuti iyo Enzymatic nzira isarudzo yakanaka kune mazhinji mafekitori. Saka, ndapota simbisa izvi nemupi wako weNMN poda pamberi pako tenga NMN yakawanda powder.

 

Chii chinonzi NAD + chine chekuita neNMN?

NAD inomirira nicotinamide adenine dinucleotide. Kubva kubhakitiriya kusvika kumhuka, ndeimwe yemamorekuru akawanda uye akakosha mumaseru metabolism. Mune imwe nzira, muviri wese une NAD chinhu, isu tinogona kufa mumasekondi makumi matatu pasina kuvapo kweNAD +. Izvo zvinotiudza kuti NAD + chinhu chakakosha kwazvo kumuviri wedu, inogona kutsigira muviri wedu kushanda senguva dzose mazuva ese.

+ Aya maitiro akakosha zvakanyanya Mamwe mabasa eNAD + anosanganisira kugadzirisa kurara / kumuka kutenderera. NAD + inotyaira sirtuins kugadzirisa metabolism uye chengetedza chromosomes yakagadzikana. Morekuru rinobatsirawo kugadzirisa DNA yakanganisika.

Nicotinamide Mononucleotide 04

 

Saka, zvakakosha kwazvo kuchengetedza NAD + nhanho yemuviri wedu. Izvo zvakare zvakatiudza isu tinowana vadiki nekuwedzera NAD + nhanho, tibatsire kurwisa kukwegura. Zvino chii chatinofanira kuwedzera yedu NAD + nhanho?

Sezvo masayendisiti akataura, kune nzira nhatu dzekuwedzera NAD + nhanho:

Yakagadziridzwa chirongwa chekudya. Kudya kwakanyanya mumafuta uye kwakaderera mumahydrohydrate, senge keto kana Atkins-dhayeti dhayeti, inosimudzira nyika ketosis. Kana muviri wako uri ketosis, iwe unoshandisa mafuta kune simba panzvimbo yeglucose. Iyi nzira inowedzera huwandu hweNAD + kusvika kuNADH, nekudaro ichidzivirira muviri wako kubva kune oxidation.

NAD + Kuwedzera. Muviri wako unokwanisa kukwana kuburitsa NAD +, saka kuwana chinowedzerwa kubva kune mukurumbira mugadziri uyo anopa kuchena garandi inzira isingarwadzi yekusimudzira aya mazinga mumuviri wako. Izvi zvinowedzera zvinosanganisira nicotinamide, nicotinic acid, nicotinamide mononucleotide (NMN), uye nicotinamide riboside (NR). Ot Nicotinic acid inoshandura kuNAD + kuburikidza nhanho nhatu. Padanho rekutanga, iyo enzyme NAPRT inoshandura nicotinic acid kuita nicotinic acid mononucleotide (NAMN). Padanho rechipiri, iyo enzyme, NMNAT, inoshandura NAMN kuita nicotinic acid adenine dinucleotide (NAAD). Iyo enzyme, NAD + synthetase (NADS) inoshandura NAAD kuNAD +. NAD + biosynthesis munzira yekununura inosanganisira nicotinamide kutendeuka kuNMN kuburikidza ne enzyme, phosphoribosyltransferase, NMNAT. Iyo enzyme inoshandura NMN kuNAD +.】

Kudzidzira zvenguva yekutsanya. Nepo kudzikiswa kwakanyanya kwekoriori kana nguva refu yekutsanya kusingakurudzirwe kune vazhinji vakuru, kutsanya kupfupi kana kwepakati kunogona kuratidza mhedzisiro yakafanana. Kutsanya kuri pakati nepakati inzira inogadzirika yekuunza muviri wako kunguva dzakareba pasina kudya, kukwidza ako NAD + mazinga nenzira yakafanana neketosis.

Zvinosuruvarisa, kudya kwakakora-mafuta kunogona kusakurudzirwa kana uine chirwere cheshuga, chirwere chemwoyo, kana kuwedzera LDL cholesterol. Saizvozvo, kutsanya kunogona kusakurudzira kune avo vane mamiriro ekurapa uye zvinowanzoomera kuenderera nekufamba kwenguva. Nekudaro, kuwedzera pamwe neNMN powders kana imwe NAD inowedzera inowanzo iri nzira yakachengeteka uye iri nyore yekusimudzira yakawedzera kugadzirwa kweNAD.

Mushure mekunge taziva NAD + uye kuti inoshanda sei, ndinofungidzira kuti iwe unofanirwa kuziva kuti sei tichida kutora NMN powder? Inoshanda sei kana NMN upfu mumuviri wedu. Nenzira iri nyore, NMN ndiyo inotungamira yeNAD + isati yapinda mumuviri wedu. Kutora NMN upfu kunogona kuwedzera NAD + nhanho uye kutibatsira kurova kumhanya kwekukwegura.

 

Iko NMN Powder Yakachengeteka Zvinowedzera here? 

Mazhinji e data kusvika ikozvino abva kumhuka, idzo dzisina kuratidza chero mhedzisiro. Yenguva refu-mbeva kudzidza zvakare hakuna kuratidza huturu, zvakakomba mhedzisiro, kana kuwedzera kufa kwehuwandu mukati memwedzi gumi nemaviri yekupindira nguva. Sekuziva kwedu, Kuedzwa kwevanhu kwakaitwa munguva pfupi yapfuura kubva muJapan. Chinangwa chekutongwa kwaive kuona kana NMN upfu hwakachengeteka kutora. NMN yakapihwa kune gumi varume vane hutano. Masero e12, 10, uye 100 mg NMN yakapihwa. Iyo imwechete yemuromo manejimendi yeNMN haina kukonzera chero akakosha emakiriniki zviratidzo kana shanduko mune makuru biomarkers senge kurova kwemoyo, kuwedzerwa kweropa, okisijeni kuzadza, uye tembiricha yemuviri. Muedzo unobatsira kusimbisa kuti, kazhinji, hupfu hweNMN hwakachengeteka uye hunoshivirirwa zvakanaka; Kusvikira izvozvi, kuyedzwa kunogona kutarisirwa sekubudirira. Ichi chidzidzo chakayera zvakare mhando yekurara, uye haina kuwana mutsauko pamberi uye mushure mekushandisa kweNMN.

Nekuda kwenhamba shoma yemiedzo yevanhu, masayendisiti ari kuenderera mberi nekuongorora mhedzisiro yeNMN, achiedza kuwana yakawanda kiriniki data kubva kumiedzo yevanhu, kuitira kuti ave nechokwadi chekuti chigadzirwa chitsva ichi chekupokana-kukwegura chakatangwa zviri pamutemo.

Panguva imwecheteyo, tinofanirwa kutaura nezvaDr David Sinclair anova mumwe wevanhu zana vane mukurumbira pasi rese neTime Magazine, anga achitora zvinowedzerwa zveNMN kwemakore neshamwari muindasitiri yekuchembera. Akagovana ruzivo nesu mushure mekutora NMN upfu kwenguva yakareba. Iye akati: “Ini ndinogara ndichitora 100 gramu yeNMN mazuva ese, pamwe nezvimwe zvinowedzera zvinosanganisira resveratrol, metformin, uye aspirin. Handina kana chimwe chandakaona kunze kwekurwadziwa nemudumbu kusvika zvino. ” Akayeuchidza zvakare nezvekuti isu tinofanirwa kuchengeta hupfu hweNMN munzvimbo inotonhorera kana zvakanaka mufiriji, nekuti NMN inodzikisira kuNicotinamide muchetura mumuviri wako kana NMN ichengetwa mumhepo inopisa / inodziya.

 

Ndeapi Makomborero Anogona Kuunzwa neNNN Powder kuMuviri Wangu? 

NMN (Nicotinamide Mononuleotide) ndiyo inotungamira yeNAD +. NMN yekuwedzera inokwidza DAN + yehutano hwakakosha & hurefu kwenguva refu pakati pekupa mamwe mabhenefiti ehutano. Parizvino, hapana humbowo hweyese yakaipa mhedzisiro, kunyangwe pamadosi epamusoro kwenguva yakareba. Yakaratidzawo bhenefiti mabhenefiti muzviitiko zveType II Chirwere cheshuga uye Dambudziko reAlzheimerPazasi pane gumi ebhenefiti yepamusoro yeNMN powder:

♦ Anti-Kuchembera mhedzisiro

♦ Inowedzera kubereka muvakadzi

Inovandudza kuona & kuona

♦ Simba rekusimudzira

♦ Inofambisa kugadzirisa kweyakavhunika tambo dzeDNA

Inovandudza itsvo mashandiro & kuyerera kweropa

♦ Inoderedza cholesterol & triglycerides

♦ Inovandudza Immune system basa

Inokurudzira hutano hwemoyo & basa

♦ Inovandudza mitochondrial basa nekudzora neuroinfigueation

 

Ini Ndinogona Kuwana Yakaringana NMN Kubva Kudya Ku Anti-Kukwegura? 

Mhinduro ndeyekuti "kwete kwete". Nekuti NMN inowanikwa zvakasikwa muzvikafu zvakawanda uye unogona kuzviwana zviri nyore muhupenyu hwedu.

▪ Broccoli

▪ Kabichi

▪ Gaka

▪ Edamame

▪ Avocado

▪ Nyanya

 

Nicotinamide Mononucleotide

Zvino, unofanira kunge uri kufunga kuti: "Kana NMN ikawanikwa mune chikafu, handikwanise here kuwedzera mazinga angu eNAD + nekudya zvimwe zvezvikafu izvi?" Ndiwo mubvunzo wakanaka. Nekudaro, ini ndinofanira kuratidza kuti kana iwe uchida kudzosera kukwegura neNMN, uchafanirwa kudya huwandu hwakawanda hweichi chimwe nechimwe cheichi chikafu. Zvinosuruvarisa, iyo NMN mune mashoma madzinde e broccoli haina kana kukwana kuti itange kutanga kuwedzera maNMN mazinga. Mune mamwe mazwi, kuti uwane anenge 1mg yeNMN, iwe unofanirwa kudya inenge 1kg ye broccoli! Zvakawanikwa kuti kusimudzira mazinga eNAD + muvanhu, iwo matanho eNMN anofanirwa kunge ari mumazana emamirigiramu padhizaini. Iyi nzira iri kumusoro kupfuura izvo zvatinogona kuwana kubva kuzvikafu zvedu, zvisinei kuti yakawanda sei broccoli yatinodya. Nekudaro, isu tinofanirwa kufunga nezve kutora NMN upfu sezvokuwedzera pakurwisa kukwegura muhupenyu hwedu, zvinogona kubatsira muviri wedu kuwedzera zvimwe NAD +, kurwisa kuchembera.

 

Ungatora Sei NMN Powder? 

Mubvunzo wekupedzisira, takataura Dr. David Sinclair uyo akatora 1g NMN mazuva ese. Ipapo 1g ndiyo dosi inoshanda kwazvo kwatiri kuti tiwane mabhenefiti eNMN, handiti? “Kwete!” Paunenge uchishanda kuti yakawanda sei yaunoda kutora, zvakakosha kuti utarise mashandisiro anoita iyo NMN uye yayo bioavailability. Zvakare, muviri wakasiyana uine maitiro akasiyana. Tinoda kuziva kuti zvakanaka kutora NMN, kuti tingaitora sei uye kuti yakawanda sei dosi yatinofanira kutora kana wagadzirira kutora upfu hweNMN.

 

Ngatitaurei mubvunzo wekutanga: Ungatora sei NMN upfu? 

NMN inoshandiswa mune zvingasarudzwa zvina izvo zvinokanganisa huwandu hwayo iyo NMN inogadzira iyo yako yeropa system: hupfu, sublingual poda, akajairwa makapisi, uye gastric-inomiririra makapisi.

Kuti unzwisise kuwanikwa kwechinhu, munhu anofanirwa kunzwisisa iyo Yekutanga Pass Mhedzisiro (zvinoreva kuti yakawanda sei chinhu chakaparadzwa kana kugadziriswa nechiropa chisati chanyatsopinda muropa). Iyi ndiyo pfungwa yakaoma, ndinofungidzira kuti vhidhiyo iyi inogona kutibatsira kuti tinzwisise kuti inoshanda sei uye nei zvichikosha kuti tizive tisati tatora poda yeNMN. Nekuda kwekutanga-kupasisa metabolism, kunwa kwemuromo kweNMN kwakanyanya kushomeka kupfuura madiki emitauro kana gastro-inomiririra makapisi. Kana hupfu hweNMN hunotorwa nemuromo (kungave kana uchidyiwa kana kusanganiswa nemvura) yakawanda yacho inoparadzwa nedumbu acid. Iyo NMN yasara inozogadziriswa nechiropa. Maitiro echiropa ekugadzirisa sei NMN anogona kuve nemhedzisiro yakakura pakuwanikwa kwebhaoavailability. Zvinogona kunge iri chidimbu cheNMN chete chinoita kuti ive yako system. Zvakare kuvandudza ako NAD + nhanho, iwe unogona kutora kunonoka-kuburitsa NMN capsules ine Sirtuin Activator senge Resveratrol ine yakazara-mafuta yogati iyo inobatsira iyo bioavailability yeResveratrol.

Asi kana NMN (kana chero mushonga kana chinowedzerwa) chikatorwa zvishoma, chinopinda mukati memucheka (pasi perurimi) uye chinopfuura chakananga muropa. Kubva ipapo inofamba yakananga kuuropi uye dzimwe nhengo, ichipfuura iyo "yekutanga kupfuura" kubva pachiropa. Ndicho chikonzero ichi, kuti isu tinotenda kutora zvinyorwa zvemitauro yeNMN kana mune gastric-resistant capsule ndiyo inonyanya kushanda uye inoshanda. Inogona kuda madosi epasi pane kutora NMN upfu nemuromo kana mu standard capsule fomu.

  1. Chii chinonzi NMN Powder?
  2. Chii chinonzi NAD + chine chekuita neNMN?
  3. Iko NMN Powder Yakachengeteka Zvinowedzera here?
  4. Ndeapi Makomborero Anogona Kuunzwa neNNN Powder kuMuviri Wangu?
  5. Ini Ndinogona Kuwana Yakaringana NMN Kubva Kudya Ku Anti-Kukwegura?
  6. Ungatora Sei NMN Powder?
  7. Ini ndinofanira kutora zvimwe zvinowedzera neNMN pamwechete?
  8. Iko NMN Yakanaka Inobatsira Pakurwisa COVID-2019?
  9. NMN VS. NR: Ndeupi Ari Nani?
  10. Ndingaite Sei Kuti Ndiwane Iyo Yakanyanya NMN Powder?
  11. Nzira Yokuchengetedza Sei NMN Powder?
  12. Iko Kune Iko Chero Chaicho Ongororo paNMN Powder?
  13. pfupiso

 

Mubvunzo unotevera: Ndeipi nguva yakanakisa yekutora hupfu hweNMN? 

Kuchembera chirwere chinogona kurwiswa pamwe nemubatanidzwa wakakodzera wezvinowedzera uye maitiro, sekutsvagurudza kutsva kubva kuYunivhesiti yeWaterloo. Vachishandisa yakazara masvomhu modhi, vaongorori vakawanawo kuti nguva yakanakisa yezuva yekuti mumwe munhu atore zvinowedzera izvi zvinoenderana pazera ravo. Zvimwe zvekurwisa kukwegura zvinofanirwa kutorwa nevechidiki husiku, nepo vanhu vakuru vachifanira kuzvitora masikati kuitira kubudirira kukuru. zvinokanganisa muviri wako, zera rako uye mararamiro ako, ”akadaro Layton. “Vanhu vanofanirwa kucherechedza nguva yavanodya nekuona kuti zvinoenderana nezvimwe zvinhu munharaunda mavo zvinokanganisa kurara / kumuka kwavo kana wachi yemuviri.

Saka, painenge yakanakisa nguva yekutora hupfu hweNMN? zera ndicho chinhu chikuru usati wafunga kuti tinotora zvakadii hupfu hweNMN. Semuenzaniso, zvakadzidzwa kuti NMN zvinowedzera zvinonyanya kubatsira kune vechidiki kutora maawa matanhatu mushure mekumuka. Pane zvinopesana, zvidzidzo zvinoratidza kuti Resveratrol zvinowedzera zvinoshanda zvakanyanya kana vechidiki vakavatora masikati. Kune vakuru vakuru, zvakakosha kutora izvi zvinowedzera mumasikati.

 

Mubvunzo wekupedzisira: Yakawanda sei isu yatinofanira kutora NMN poda? 

Mushure mekunge taverenga iyo mibvunzo iripamusoro, isu tinofanirwa kuziva kuti yega yega inoda kuwana wega muyero weNMN upfu, kwete chaiyo muyero sekurudziro. Zvino tingaverenga sei muyero weNMN pachedu? Sezvazvino zvidzidzo, zvine hukama nehuremu hwedu. Kubva pakudzidza: "Tichifunga kuti 100 mg / kg / zuva reNMN rakakwanisa kudzora kuwanda-kwakabatana kuderera kwemuviri mumakonzo. zviwanikwa kuvanhu. ” Sekureva kwevanyori vechangobva kuongorora ongororo, kutora hushoma hushoma hwe8 mg yeNMN pa kg yehuremu hwemuviri pazuva. Kana chidzidzo chacho chiri chechokwadi, saka kuti uwane kuti yakawanda sei NMN yaunoda pachidiki, unotanga wawana huremu hwako mu kg, wobva wawanda ne 8. Semuenzaniso, kana huremu hwako huri 8kg, chipimo chinokurudzirwa chiri nezve 50mg.

Kana iwe ukatora yepamusoro-soro yekuwedzera ine yakanakisa bioavailability, seAASraw's NMN poda, ipapo tinokurudzira madosi anotevera ayo akavakirwa pamhinduro yevatengi:

 

uremu Dosage YeReferensi (zuva nezuva)
45kg 45kg * 8mg = 360mg
50kg 50kg * 8mg = 400mg
60kg 60kg * 8mg = 480mg
70kg 70kg * 8mg = 560mg
90kg 90kg * 8mg = 720mg
Aya madosi anongori serefence. Unofanira kutora zvakadii? Zviri kwauri. Asi kana iwe ukawana iyi chaiyo chidzidzo ichigutsa, unogona kutanga kuverenga kwako pa8 mg pa kg yehuremu hwemuviri pazuva.

 

Ini ndinofanira kutora zvimwe zvinowedzera neNMN pamwechete? 

Kana iwe uri mucherechedzi akanaka, iwe unofanirwa kunge wakaona kuti Dr. David Sinclair anotora zvinopesana nekukwegura zvinowedzera zuva rega rega, kwete chete NMN powder, zvakare iine vamwe, senge resveratrol, metformin, uye aspirin ... neNMN upfu pamwe chete? Sei?

Base pane izvo zvidzidzo kubva kuna Dr. David Sinclair nechikwata chake, kutora NMN poda zvimwe zvinowedzera zvinobatsira zvakanyanya pakurwisa kukwegura. Parizvino, ini ndichagovana 3 zvinowedzera patinotora NMN upfu. 2 zvinowedzera zviri resveratrol uye pterostilbene. Resveratrol ndeye stilbenoid inowanikwa muganda remazambiringa mune yakaderera huwandu. Zvidzidzo zvakaratidza kuti resveratrol inogona kudzora njodzi yehosha yemoyo, kenza uye neurodegeneration David Sinclair anotenda kuti resveratrol inoshanda yakabatana neNMN. Resveratrol inodiwa kuti ishandise sirtuin majini (ayo anochengetedza edu DNA uye epigenome), nepo NMN ichidikanwa kupa mafuta masosi, zvisinei, resveratrol inonetsa kutorwa nehuswa, uye diki resveratrol inoguma mumuviri yaputswa pasi nekukurumidza, saka pterostilbene ndiyo imwe nzira iri nani. Pterostilbene mamorekuru anotaridzika chaizvo akafanana ne resveratrol, asi yakanyura irinani zvakanyanya uye yakanyatsogadzikana mumuviri wemunhu.

Imwe yekuwedzera ndeye trimethylglycine (TMG), patinotora poda yeNMN kwenguva yakareba, NMN inopedza methyl mapoka mukati memiviri yedu, sedziviriro, zvinofungidzirwa kuti zvakakosha kutora TMG (amino acid inozivikanwa se betaine) kuti ipe methyl mapoka. Kana NMN yashandurwa kuita NAD +, nicotinamide (NAM) inoumbwa. Matanho akakwirira enicotinamide haana kunaka kumiviri yedu uye kuti miviri yedu ibvise nicotinamide inoda kuiswa methylated muN-methyl nicotinamide iyo inoburitswa mukati medu weti. Kuti uwane methylate NAM, muviri unofungidzira kuti unotora kubva kumatura edu emethyl mapoka. Mufungo uyu ndewekuti iyo NMN yaunotora, anowedzera mapoka emethyl anodiwa kubvisa iyo NAM.

Mune podcast pazasi naDr.Mercola, Dr. David Sinclair akataura kuti anotora TMG sedziviriro kudzivirira izvi kuti zviitike, tinogona kudzidza rumwe ruzivo kubva muvhidhiyo iyi yaDr David Sinclair:

Kunyangwe akawanda ekuwedzeredza achinzi akachengeteka uye anobatsira kumitumbi yedu, zvinogara zvakanaka kutarisa nemurapi wako wehutano usati watanga kuitora, kunyanya kana uine hutano mamiriro uye uri kushandisa chisingaperi mishonga. Gara uchiteedzera yakadomwa dosi.

 

Iko NMN Yakanaka Inobatsira Pakurwisa COVID-2019? 

Kutanga kupindura kwemuviri kutyisidziro inotapukira senge COVID-19, inozivikanwa sein innate immune activation, zvinoenderana neNAD +. Utachiona hutachiona hunopedza NAD + nekuti hutachiona hunokonzeresa maseru ekudzivirira anokonzera kuwedzera kweNAD + kudzikisira kudzivirira hutachiona kubva pakutora sero. Kunyanya kudzikiswa kweNAD + kusangana kwakaratidzirwa muCOVID-19 uye vamwe vaongorori vanofunga ichi ndicho chinhu chikuru chikonzero nei hutachiona uhu huchityisa, kunyanya kune avo vakapererwa neNAD + kuchengetedza. Dr. Zhavoronkov akakurudzira kuti Kuyedza yakaderera-dose rapamycin wega kana mukubatana ne metformin, uye NAD + zvinowedzera zvakaita se nicotinamide riboside (NR), kana nicotinamide mononucleotide (NMN) inogona kubatsira kuchengetedza vakwegura kubva kuhutachiona hwegerolavic nhasi uye zvakare kunogona kusimudzira kupora kwehupfumi kana denda repasirese rapera.

Uye zvakare, zvidzidzo zvakaratidza kuti NAD + inogona kukonzera immune system kupindura kuchengetedza muviri kubva kune coronavirus senge COVID-19. Ongororo yakaburitswa Kurume 23, 2020 neIsfahan University yeMedical Sciences inopa humbowo hwekuti yakaderera NAD + nhanho dzinogona kusungirirwa kune kwakanyanya kusagadzikana uye huwandu hwehurwere mudenda re COVID-19. Zvinoenderana nemakiriniki ekuedzwa, NMN inowedzera inowedzera NAD + kumatunhu evechidiki. Kuita kuti iyo NAD + mamorekuru iwanikwe kune maSIRT1 majini inowedzera kugona kwavo kuchengetedza muviri kurwisa chirwere uye kudzikira. Sezvo zvimwe zvidzidzo zviri kuitiswa, vaongorori vari kuona kuti NAD + zvakare ine basa rakakosha kuita mukugadzirisa masimba edu ezvirwere.

Vakawana zvakare kuti macrophages (rudzi rweyechena sero reropa iyo inodya vangango pinda senge mabhakitiriya, fungi, zvipembenene, uye mavairasi) vanoshandisa nzira inogadzirwa neNAD + kuona kupona kwesero uye kudzora kuzvimba. Zvese mune zvese, zvidzidzo zviri kuratidza kuti NMN uye nemhedzisiro inokwidza mazinga eNAD + anogona kutora chinzvimbo chakakosha pakubatsira miviri yedu kurwisa hutachiona nemabhakitiriya. Mune mamwe mazwi, ine mukana wekusimudzira masimba edu ekudzivirira muviri uye kuvabatsira munguva dzehutachiona uye kurwara.

Nyaya yekuongorora yakaburitswa muna Kubvumbi 22, 2020 naDr.Robert Huizenga MD paUniversity yeChicago vachitsanangura mhinduro yake kumukadzi ane makore makumi mashanu nemashanu ekuberekwa uyo akange arapwa muchipatara neCOVID-55 munaKurume 19. Hutano hwake hwakaramba huchiwedzera uye pazuva 16 aive nepneumonia iri pachena, cytokine dutu uye yakanyanyisa kukwidziridzwa hsCRP, isiri-chaiyo yekumakisa chiratidzo. Dr. Huizenga akamubata nemuromo weNMN, betaine naNaCl (inozivikanwa kudzikisa IL-13) uye akaenderera mberi nekurapwa kwezinc kwaakange apihwa kare. Nezuva 6, fivhiri yake yakagadziriswa uye zviratidzo zvakavandudzwa zvakanyanya. Pakazosvika zuva regumi nenomwe akasunungurwa kuti aende kumba. Nezuva 15, aive asymptomatic. Vamwe vaviri vakwegura varwere vaibatwa neiyo imwechete "cocktail" uye vese vakasangana zvakafanana kupora.

 

NMN VS. NR: Ndeupi Ari Nani? 

Nicotinamide mononucleotide (NMN) uye nicotinamide riboside (NR) zvinhu zvinotsanangudza biosynthetic kune yakakosha mamorekuru yemetabolism-nicotinamide adenine dinucleotide (NAD +) .Morekuru zvimiro zveNMN neNR zvakangofanana, kunze kwekunge NMN ine yakawedzera phosphate boka. Iri rakawedzera phosphate boka rinoita kuti NMN ive yakakura morekuru kupfuura NR. NR (nicotinamide riboside) uye NMN (nicotinamide mononucleotide) zvinowedzererwa zvese zvinowanzo kuvezwa maviri ezve anovimbisa ekuwedzera ekudzora kukwegura.Kutora NR neNMN upfu kunowedzera mazinga eNAD +. Matanho epamusoro eNAD + anodzivirira epigenome yedu uye DNA. Kuwedzera kweNAD + mazinga kunotungamira kune akawanda hutano mabhenefiti pane akasiyana nhengo, senge huropi, yemoyo system, uye mhasuru.

Tichifunga kuti NR neNMN zvinowedzera NAD + nhanho, ivo vanowanzozonzi maNAD anosimudzira. Ongororo dzakawanda dzinoratidza kuti NR neNMN zvinogona kugadzirisa zviratidzo zvakasiyana zvekukwegura, senge epregnegregregated, kukuvara kweDNA, kuunganidzwa kweprotein, inflammaging (kuzvimba zvine chekuita nekukwegura) uye dzimwe nzira dzakasiyana dzekukwegura.

Asi iwo mubvunzo mukuru wechokwadi ndewekuti: ndeupi ari nani, NMN poda kana NR upfu?

Parizvino, hapana zvidzidzo zvinoenzanisa NMN neNR musoro-pane zvine chekuita nezvehutano mhedzisiro uye nehupenyu hwehupenyu. Ngatifananidzai NMN neNR:

NMN vs NR

Ndingaite Sei Kuti Ndiwane Iyo Yakanyanya NMN Powder? 

Ini ndinotenda kuti iwe wawana vazhinji vatengesi kana iwe ukaisa "NMN powder" paGoogle, kuitira kuti iwe usazive kuti ndeipi iri nani kana inokodzera iwe. Isu tinoda kuziva izvo zvatinofanira kutarisa kana tichitaura neNMN powder mupiki. Zvekugadzirisa iri dambudziko, ndataura nevazhinji vanotengesa veNMN poda online uye ndonongedza runyorwa rwekureva:

 

(1, Yekutanga Kuongorora

Iwe unofanirwa kutarisa webhusaiti yavo kana zvitoro pamhepo, ita shuwa kuti ivo vanovimba nekutengesa, kwete kubiridzira Enda kune yavo webist kana zvitoro, taura navo, bvunza mibvunzo chero chaunoda. pavanopindura mibvunzo yako, unogona kunzwa kana iko kuvimba, sekuziva kwedu tese, kutendeka ndiko hwaro hwekudyidzana kwese. Paunobvunza mibvunzo yavo, unogona kutaura nezve izvi zvinhu: Kugadzira hupfu hweNMM, chitupa cheNMN upfu, kugona kweNMN upfu….

 

(2)Quality Guarantee

Iyo yakanakisa NMN poda ichave ne99% kuchena kana kupfuura. Izvo zvakare hazvizove nechero mafillers kana zvigadzirwa zvakadai seGMOs, dairy, zai, soy, gluten, maikemikari ekugadzira, simbi dzinorema, kana zvinonyungudika zvinoshandiswa mukugadzirisa chaiko kwechigadzirwa. Mazhinji emanyepo eNMN poda anoshandisa mafiraya kana zvinokurudzira kugadzira yakawanda yechigadzirwa. Izvi zvinogona kuisa hutano hwako panjodzi huru nekuti iwe hauzive zvauri kutora. Kana iwe uri kutenga yako NMN kubva kune kambani inongotengesa maNMN capsules, zvinogona kuve chero chinhu.

 

(3)Inoenderana Magwaro - Kwayedza Nhoroondo

SeNMN fekitori yehupfu, zvinyorwa zvinoenderana (COA, HPLC, HNMR, MS) zvichabuda mushure mekunge vaburitsa zvigadzirwa zvematch, vanoda kutarisa mhando yacho, votumira kuma3-labs kuti vaedze (izvi zvinosanganisira kuchena, kusvibiswa, Uye simbi dzinorema. Iwe unogona kutarisa webhusaiti yemutengesi kune yechitatu-bato yekuyedza ruzivo, kana kubata kwavo vatengi vatengi zvakananga. Kuongorora kwechitatu-bato kuyedza inzira yakapusa yekuona kuti uri kutenga kubva kune inozivikanwa nzvimbo. Chero kambani inoshandisa yechitatu-bato kuyedza inofanira kufara kugovana iyo ruzivo newe.

 

(4)Enzanisa Iyo Mutengo Pakati Pevanoverengeka Vanopa

NMN Mutengo ndeimwe metric iyo iwe yaunogona kushandisa kuyera kukodzera kwevatengesi, nekutarisa vanoverengeka veNMN vatengesi veese poda uye makapisi iwe unowana pfungwa yeavhareji mutengo pa gramu. chenjera iyo yekunyepera yeNMN poda, kana yakaderera mhando zvigadzirwa. Zvinogara zvichiedza kuda kuchengetedza mari chero mukana waungagone, asi neNMN chaizvo, iwe unowana chaunobhadhara. NMN yakaderera mutengo inogona kunge iri giredhi rekudya, kwete giredhi remishonga, zvinoreva kuti mabhenefiti eNMN haana kufanana Sarudzo dzakachipa dzeNMN, idzo dziripo pamusika, igiredhi rekudya uye inogona kunge iine zvinosvibisa. Muchokwadi, pane dzimwe nguva pane pasi pe10% NMN mune yekudya-giredhi NMN. Kuyedza izvi kunze, isu taive nechikafu-giredhi NMN sampuro yakaedzwa uye yakadzoka ne8% NMN Kufunga bhajeti yako kwakakosha, asi unogona kupedzisira wabhadhara yakawanda mukufamba kwenguva paunenge uchisarudza zvigadzirwa zvemitengo yakaderera yeNMN kana iwe usingaone chero hutano hunobatsira kubva kwavari.

 

(5)Excellent Customer Service

Hunhu NMN hunobva kunevanopa zvemhando yepamusoro, mutengesi anovimbika anofanirwa kuve nebasa rakanakisa revatengi. Kana iwe uchitaura nemutengi anomiririra, tumira mibvunzo yese kwavari uye ivo vachakupindura munguva pfupi.Uyezve, ndikuzivise maitiro ese ekutenga, maitiro ekuzviita uye kukuzivisa iwe zvaunofanirwa kuita padanho rinotevera, maitiro ese anofanira uteedzwe newe. Ndokumbirawo muyeuke kuti yakanaka sevhisi sevhisi munhu anonzwa kugadzikana kutaurirana nemumwe chero nguva.

 

(6)Ongororo kubva kune Vamwe Vatengi

Sezvakawanda, tinogona kuwana dzimwe ongororo nezve iyo kambani kana kambani yakapa hupfu hweNMN kwenguva yakareba, kana ivo vanogona kupa kumwe kudzorera kubva kune vamwe vatengi. Mushure mezvose, tinogona kuziva kuti ichokwadi chero bedzi vaine rekodhi yekutengesa uye chaiyo mhinduro yevatengi. Ehe, isu tinofanirwa kuziva kuti ongororo kubva kune vamwe vatengi chete sereferenzi patinofunga kutenga NMN upfu, zvinoenderana newe pakupedzisira.

MUTSVENE ikambani ine fekitori, inogona kuburitsa huwandu hweNMN upfu uye zvimwe zvinopesana nekukwegura zvinowedzera. Iwe unoenda kune webhusaiti yavo-www.aasraw.com chero nguva uye ubvunze vatengi vavo, bvunza chitupa chehunhu uye mitsara yekuyedza mu3.rd-rabhu, simbisa kuti yavo NMN poda ndeye 99% yakachena chemakemikari giredhi uye iri yepamusoro imwe. Sekuziva kwangu, vanogona kutumira chigadzirwa icho chawakaraira mumazuva 1-3 ekushanda, kunyangwe maawa gumi nemaviri mushure mekurongeka kwasimbiswa, kugona kwebasa kwakanyanya kwazvo, ndinofanira kuvapa chigumwe cheizvi. Iwe unowana iyo NMN poda pikicha uye yekutevera nhamba kubva kwavari mushure mekuraira, ipapo iwe unogona kushandisa kuteedzera pasuru online uye uzive kuti iri kupi, kure sei kumba kwako. Dzidza zvakawanda nezve AASraw izvozvi

Nzira Yokuchengetedza Sei NMN Powder? 

Nicotinamide riboside (NR) uye nicotinamide mononucleotide (NMN), yakaratidzirwa kusimudzira hosha dzakabatana nezera mumhuka. Ivo vakanyatsoshivirirwa pamwero wakakwira uye zvinobudirira kusimudza NAD + nhanho. Aya mamorekuru haasi shefu-yakagadzika patembiricha dzakakwirira kana mumamiriro ekunyorova kwakanyanya, zvakadaro. Ivo vanokurumidza kudzikisira kuita nicotinamide, iyo inotitadzisa zviitiko zvemasirusi uye PARP, DNA yekugadzirisa enzyme.Zvemhedzisiro, NMN upfu inofanirwa kuchengetwa mumidziyo yavo yekutanga uye kure nechero kunobva mvura. NMN poda isina kumedzwa kwemwedzi mitatu kana kupfuura inogona kuiswa mufiriji kuti ive nechokwadi chekuti inochengetedza zvizere potency. Sezvo mutungamiri wepasi rose, AASraw inogara ichipa iyo yepamusoro soro mhando uye inoshanda kwazvo NAD + neNMN poda inowanikwa.

 

Iko Kune Iko Chero Chaicho Ongororo paNMN Powder? 

Tom anobva kuUK: Ini nemukadzi wangu takatanga kutora hupfu hweNMN mwedzi yakati wandei yapfuura uye takashamisika ndakamira kuridza ngonono uye matambudziko emukadzi wangu ganda akatanga kudzikira! Isu tinongonzwa kujekeserwa zvirinani kwepfungwa nenzira zvakare simba rakawanda, ini handina kumbobvira ndatora chinowedzera kuti ndave nemhinduro inoratidzika kune ini ndinoreva iwe unotora mavitamini akawanda nemishonga yekuwedzera asi hautombonzwa mhedzisiro yacho! Ichi ndicho chinoshamisa kwazvo chinowedzerwa nemhando yemunhu chakawanikwa asi uye kungoita ekudzoresa mamirioni emasero mumuviri wemunhu chinhu chinoshamisa chekuwana kukwegura! Ini ndinofunga munhu wese achaziva nezve iyi piritsi munguva pfupi iri kutevera uye gomarara kutsvagurudza kuchacherechedzawo, isu tiri mune makumi mashanu uye hatigone kutaura zvakakwana nezve manzwiro atinoita manzwiro! Ndiani asingade kunzwa kuve noutano achiwedzera izvi kune yako anti-kuchembera zvinowedzera kudya zvichachinja hupenyu hwako kuti uve nani kuvimba neni !!!

liMei kubva kuChina: Ini ndakasarudza poda yeNMN nekuti ndakaverenga inobatsira oxygenate ropa uye rinopa oxygen munyama yangu yemuviri. Muviri wangu waidaidzira chigadzirwa ichi, ndainzwa kuneta uye kusakwanisa kutarisisa. Ndave kutora poda yeNMN kwevhiki mbiri ikozvino. Ndakaona kuwedzerwa kwesimba, ini ndiri kukwanisa kutora chikamu mune yakanyanya cardio kurovedza chirongwa mushure mekushanda zuva rese. Pfungwa dzangu dzakajeka, handisi kunzwa kukotsira mumisangano. Ndiri kufara kwazvo neNMN zvinowedzera ini ndiri kuwana mhedzisiro yandave ndichitsvaga. Pamusoro pezvo, ndinofanira kuti: Mutengo weNMN wakakwira zvishoma kwandiri asi ndinoda kusimbirira pakuutora, nekuti ini ndoda kuva mudiki, haha…

Gary anobva kuAustralia: Ichi chikuru anti-kuchembera zvinowedzera. Ini ndinoona yakawedzera simba, handina kubata mwana wangu wemakore mana kutonhora, uye handinete nyore. Rudzi rwesimba randinonzwa rwakasiyana necaffeine yakakwira. Ini handinzwe kunetseka kana pamusoro-kusimudzirwa, ingo nyatso kumuka uye kutsva. Pasinei nekusvinura, kurara kwangu kwakavandudzika. Handisati ndambove nedambudziko pakurara, asi ndinogona kumuka zvakanyanya panguva yehusiku. Neiyo NMN poda ini ndinorara kwenguva yakareba mukutambanudza. Ini ndinofunga NMN iri kundibatsira munzira dzakawanda uye ini handigoni kutaura zvakanyanya zvakakwana nezvazvo.

Steven anobva kuUSA: Mushure mekudzidza nezveNMN powder uye zvinogona kuitika kubva kuHarvard Study yakaitwa naDr David Sinclair, ndakafunga kuyedza. Kubva pazuva rekutanga randakayedza, ndakaona mutsauko pasimba rangu remagetsi. Ndine makore makumi mashanu nemashanu, uye metabolism yangu inoita kunge iri kuchinja kuita zvirinani. Handina kuchinja maitiro angu ekudya, asi ndiri kurasikirwa uremu, 57 lbs mumavhiki mana. Iyo nguva span inoratidza kurasikirwa zvachose. Mudzimai wangu akarasikirwa ne14 lbs, uye anorwara nechirwere chisingawanzozivikanwa chinonzi Erythromelalgia, icho chinokonzeresa kuti magumo apise zvakanyanya nemarwadzo europathi, uye zvinowirirana. Chikamu cheNiacin chemukomboni, pamusoro pemishonga yake, chaita kuti marwadzo aderere zvishoma, uye chakagonesa kuita kwakawanda. Mushure mekunge ndamhanya kekutanga - ndakaedza iyo kubva kune vamwe veNMN poda vanopa. Iyo mukomboni yakasiyana, uye simba rakaparara. Ndosaka ndakadzoka kuMACAC4, uye ikozvino ndadzoka munzira. Iwe unoziva, ini ndinototenda mamwe eangu akapararira bvudzi jena rakasviba risina dhayi. Inoshanda Unoziva - handifunge kuti ndinotarisa makumi mashanu nemashanu zvakare.

 

pfupiso

Ipo Tsime reYouth richiri ngano inonakidza isingazadzike chero nguva munguva pfupi, sainzi iri kumashure kwemishonga yekurwisa-kukwegura inoenderera mberi. Zvichida rimwe zuva, iwe unozogona kutora chinoshamisa piritsi uye unowana hupenyu sewechidiki mudiki zvakare. Zvidzidzo mumhuka zvakaratidza zvivimbiso zveNMN zvinovimbisa muNAD + -kusimudzira uye kupokana-kukwegura. Zvino, kunyangwe ivo vaongorori vari kuenda kumberi nemakiriniki miedzo yekuongorora kuchengetedzeka uye kushanda kwemorekuru muvanhu. NAD uye NMN zvinowedzera kupa chaiko mabhenefiti kunonoka iko kwakakomba mhedzisiro yekukwegura kwemasero pane muviri wemunhu. Ndinotenda kuti zvichabatsira chero bedzi zvichizobatsira panyama yedu, Ngatitangei kuve vadiki zvakare pamwechete.

 

Reference

[1] Kumusoro, BJ, Rosenberg, MA, Jeganathan, KB, Hafner, AV, Michan, S., Dai, J.,… & van Deursen, JM (2014). SIRT2 inokonzeresa yekutarisa kinase BubR1 kuwedzera hupenyu hwehupenyu. Iyo EMBO magazini, e201386907.

[2] Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A.,… & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) yekuwedzera inokurudzira kugadziridzwa kwemutsipa mumakonzo akura: chinyorwa chetsoka cheSIRT1 activation, mitochondrial dziviriro, anti-kupisa, uye anti-apoptotic mhedzisiro. GeroScience, 1-20.

[3] Grozio, A., Mills, KF, Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K.,… & Imai, SI (2019). Slc12a8 inotakura nicotinamide mononucleotide transporter. Zvisikwa metabolism, 1 (1), 47-57.

[4] Li, J., Bonkowski, MS, Moniot, S., Zhang, D., Hubbard, BP, Ling, AJ,… & Sinclair, DA (2017). Iyo yakachengetedzwa yeNAD + inosunga homwe iyo inodzora mapuroteni-mapuroteni kudyidzana panguva yekukwegura. Sayenzi, 355 (6331), 1312-1317.

[5] Stipp D. Beyond Resveratrol: Iyo Anti-Kukwegura NAD Fad. Sayenzi American Blog Network. Kurume 11, 2015.

[6] Tarragó MG, Chini CC, Kanamori KS, Warner GM, Caride A, de Oliveira GC. + Ramba. Cell Metabolism. Chivabvu 2018, 27 (5): 1081-1095.e10. PMC 5935140. PMID 29719225. doi: 10.1016 / j.cmet.2018.03.016.

[7] Bogan KL, Brenner C. Nicotinic acid, nicotinamide, uye nicotinamide riboside: molecular kuongororwa kweNAD + preursor mavitamini muhutano hwevanhu. Ongororo yegore negore yeNutrition. 2008, 28: 115-30. PMID 18429699.

[8] Fletcher RS, Lavery GG (Gumiguru 2018). "Kubuda kweiyo nicotinamide riboside kinases mumutemo weNAD + metabolism". Zvinyorwa zveMorecular Endocrinology. 61 (3): R107 – R121. doi: 10.1530 / JME-18-0085. PMC 6145238. PMID 30307159.

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