Tsvakurudzo yeAlzheimer's disease yakakonzera dzimwe pfungwa dzakanakisisa mukutsvakurudza kwezvokurapa pamusoro pemakore ekupedzisira e20. Kunyange zvazvo vatsvakurudzi vakadzidza zvakawanda pamusoro pezvirwere, hutachiona, uye zvinokonzera, huwandu hunobudirira huri kuitwa mukurwisa chirwere chacho.

Dhigirii mushure mokuedzwa kwechirwere J147 (1146963-51-0) akasarudza kutora nzira yakasiyana. Mhedzisiro yekutanga yave inonakidza, uye vatsvakurudzi vari kuramba vachidzidza kuti iyi mushonga mutsva inopindirana sei nemasero akasiyana emuviri.


Chii J147?

J147 inonzi nootropic powder yakatanga kuumbwa mu2011. Vatsvakurudzi vakaona kuti chirwere ichi, kuburikidza nedzidzo dzakasiyana-siyana, zvinogona kuderedza kukanganwa kwemu memori uye kunonoka, kana kunyange kutendeuka, neAlzheimer mu mice.

J147 powder is phenyl hydrazide. Inotorwa kubva ku curry spice component curcumin. Icho chinhu chakanyanya kudhakwa. Pasinei nezvimwe zvinotambudza, J147 powder haina kuratidzirwa kuti inouraya. Vatsvakurudzi vakaedzwa zvakanyanya nekuda kweizvi kuburikidza nekuongorora metabolites yeJ147 muvanhu uye microsomes mouse uye mouse plasma.

Zvigumisiro zvakaratidza kuti J147 haisati yashongedzerwa nemagetsi kunonhuhwirira amines kana hydrazines.


Nzira dzeChechi dzokurwisana neAlzheimer's

Zvizhinji zvinodhaka zvakagadzirwa mumakore akapfuura e20 zvakarongedzwa pamakiti emamyloid akaiswa muhutano hwevarwere veAlzheimer. Iyi nzira inogadzirisa mupfungwa nokuti idzi mari ndiyo inokonzera masero emironda kuti afe.

Zvisinei, mushure memazana emakore e20 ikoko hakuna kumbove nekukosha kunofambira mberi mumakiriniki ekuedzwa nemumwe wemishonga inotarisa iyo hovha iripo.

Imwe nzira yakabatana yakange iri yekuedza nekutsvaga amyloid isati yasvika iyo inogadziridza. I-amyloid inoparadza masapapiro asati agadzira muzvigunwe zvepaki. Zvisinei, kunyange izvozvi zvakatariswa kare hazvina kuonekwa kuti zvinobudirira.

Kusvikira kubatanidzwa kweJ147 (1146963-51-0), kunyatsokonzerwa kweAlzheimer kwaive kusimira. Ikoko kwakanga kusina nzira yakajeka yekuenderera mberi nemumwe wemishonga yakange yakagadzirwa pamusoro pemakore ekupedzisira e20 uye chirwere chechirwere chairo chakanga chisina kukweretesa kune imwe nzira ipi zvayo yakajeka.


Nzira yeJ147 (1146963-51-0) Inoshanda neAlzheimer's

Dare rinotevera J147 rakasarudza kutora maitiro akasiyana pakurwa neAlzheimer's. Panzvimbo yekukudziridza imwezve mishonga inobata amyloid, sangano rakasarudza kuisa pfungwa pachiitiko chikuru cheAlzheimer's. Iko huru pane imwe yengozi inokonzerwa nekukwegura-saka boka rakashandura maitiro aro ekurwisa-kukwegura nzira.

Dare rakagadzira J147 kuburikidza nesero-based screens kurwisana nemakore ekukwegura kweuropi. Kubva pazvikwiriso izvi, vakagadzira J147 powder.

IJ147 powder inoshanda nekuderedza basa reAtP synthase mu mitochondria. Izvi zvakachengetedzwa neuronal masero kubva kune dzakawanda zvehutano hwehutano hwehupi. Kutsvakurudza kwakaratidza kuti chikonzero ichi chinoumba chinokonzera iyi neuroprotective inokonzerwa nekuda kwebasa re excitotoxicity rinowedzera mu neuronal cell kusakara.

Neurons inoparadzwa uye inourawa nekudzvora kweiwo mabiko emutambo wekunakidza neurotransmitter glutamate. J147 inonyanya kuderedza zvinokonzerwa nehumwe hutano hwehutano hwehutano huchikurumidza. Izvi zvinodzivirira neuroni uye, kunyanya zvinoshamisa, zvinogonawo kuita kuti kuchinja kweimwe yezvinonyanya kuitika zveAlzheimer's.


J147 Inoshanda seMurwere Anorwara Anokura

Icho mechanics yeJ147 haina kufanana nedzimwe mishonga yeAlzheimer iyo yakasvika pane imwe nzvimbo yekutsvakurudza. Nemhaka yokuti haifaniri kuisa pfungwa pamararamiro emararamiro echirwere ichi, asi zvinoshanda kuti kuderedze njodzi dzinowanikwa nehutano hunokonzera.

J147 inoshanda semunhu anopesana nekwegura. Kubva kuruboshwe rwayo, huropi hwevanhu hunoita zvimwe zvinodhaka. Izvo izvi zvinokonzerwa nezera rinokonzerwa nezera rinoita kuti nzvimbo yeAlzheimer ibudirire. J147 inodzoka kumashure kweawa pazvinhu zvinosvibisa, uye izvi zvinoita kuti zvive zvakaoma kuti Alzheimer ishande basa rayo yekuderedza mhando dzakasiyana siyana dzekuyeuka.

Zvichida kuti nzira yekupayona neJ147 inobatsira zvikuru kupfuura kungoita kurwisana neAlzheimer's. Saizvozvowo vanopesana nekukwegura vanogona kukwanisa kutsvaga zvimwe zvinodhaka zvinokonzera dzimwe zvirwere nezvirwere apo zera roga ndiro dambudziko guru. J147 haisi chirwere cheAlzheimer chete. Iko chaizvoizvo mishonga inobatsira kuchinja kukwegura pachako.


J147 Clinical Trials

Kunyange zvazvo J147 yakatanga kuumbwa mu2011, ikozvino ichisvika kugamuchirwa kwemakiriniki ekupararira. Pane imwe nhanho iri munzira, J147 yakaratidzwa kwete kungoita zvinoshamisa, asi yakaratidzwawo yakasimba.

Kunetseka kwepakutanga pamusoro pekukwanisa kweJ147 kuva chirwere chinokonzera, kana zvimwe zvakasvibiswa, zvakaratidzwa kunge zvisina musoro.

Vatsvakurudzi vanonetseka kuwana zvirwere zvekuchipatara uye vanenge vose vanobatanidzwa mukutsvakurudza kweAlzheimer vanotarisira kuti J147 icharatidza kuti inoshanda kuvanhu sezvakange iri mutsva uye mu laboratori mifananidzo.


Kutangira J147 Zviwanikwa

Pakutanga kuvatsvakurudzi vakawana kuti J147 (1146963-51-0) inogona kudzivirira, uye kuchinja, kukanganwa kwepfungwa mumakonzo ane nhaka yakagadzirirwa yeAlzheimer's. Zvisinei, seine tariro sezvo chiitiko ichi chaiva, kuvanhu, chete neA1% yevarwere veAlzheimer vane inhaka yakagara nhaka. Chimiro chakajairika cheAlzheimer's hachibatanidzi necheseti ye genetics, asi nekwekwegura pachayo.

Dare racho kupfuura kudzidza nezvemigumisiro yeJ147 pane boka reveve rinokura nekukurumidza uye rinonzwa maitiro ehutano hwemazuva ano hwakafanana neAlzheimer's age-related in the people.

Migumisiro yechidzidzo chechipiri yakanga ichivimbisa zvakare. J147 yakakwanisa kununura kukanganisa kwemagariro, kunyange kana yakarongedzwa mumatanho ekupedzisira echirwere chacho. Yakagadziridza chiyeuchidzo mumakonzo uye yakadzivisa kuwedzera kuora.

Yakawanikwawo kuti apo J147 yakabatanidzwa nefrepezil yakashanda zviri nani yekudzorera mamiriro ezvakakonzerwa neakakungwa. Asi, J147 oga ndiye akanga ari mukuru mukudzokorora chirangaridzo chepakati.


Izvo Ramangwana Rinobatsira J147 (1146963-51-0)

Icho chichiri nemugwagwa wakareba pamberi peJ147 (1146963-51-0) ichave iripo yekurapa varwere vazhinji veAlzheimer. Chokutanga mushonga unofanirwa kupedzisa kukanganisa kwekliniki yekuedza chirongwa. Kamwe keriniki miedzo yakave yakarongedzwa nevezera ravo, chirongwa cheDAA chibvumirano chichatanga.

Vatsvakurudzi vanofunga nezvekudikanwa kwekukurumidza kwechirwere chinogutsa chechirwere cheAlzheimer, asi ivo vanozvipirawo kuti vasasimudzire sayenzi. Kusvika parizvino, mhinduro yese yeJ147 inofadza zvikuru uye hapana imwe mishonga yeAlzheimer yakambotarisa izvi zvakanaka kusvika kure.


Zvimwe pamusoro peJ147:

Kuongororwa Kwezvinodhaka J147 Kukwegura kweAlzheimer | AASraw


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