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1.Nifuratel-CAS: 4936-47-4
2.Nifuratel Reviews-Technological Informations
3. Nifuratel Dosage
4.Nifuratel Application
5. Nifuratel Migumisiro-Inoshanda Sei?
6.Nifuratel Side Effects
7. Tenga Nifuratel Powder Online


Nifuratel powder video


I.Raw Nifuratel powder Basic Characters:

Name: Nifuratel powder
CAS: 4936-47-4
Molecular Formula: C10H11N3O5S
Molecular Weight: 285.28
Melt Point: 176-178 ° C
Storage Temp: -20 ° C Freezer
Color: Yakachena kusvika kune chena che Crystalline powder


1. Nifuratel-CAS: 4936-47-4aasraw

Nifuratel (CAS: 4936-47-4) inorwisa antibacterial, antifungal, uye antiprotozoal nebasa rinopesana neTrochomonas. Icho chinonzi antiprotozoal uye antifungal agent iyo inogonawo kupiwa muromo. Nifuratel haibvumirwi kushandiswa muUnited States.
Nifuratel inoratidzika kuva ne-antibacterial spectrum yechiratidzo chekuita uye inoshanda kuburikidza neClamydia trachomatis uye Mycoplasma spp. pamwe nehutachiona hweFungal spp.
Yakatorwa nemuromo, kana semukadzi wepessary, inoshandiswa mukurapa kwezvirwere zvakasiyana-siyana zvegenito-urinary tract, kunyanya kana pasina kunyatsoongorora kunowanikwa. Semuenzaniso, inogona kushandiswa mukurapa kwevakadzi vakaratidza kubuda kwemudzimai apo pane kusava nechokwadi kana chikonzero chacho chiri Trichomonas vaginalis kana Matanda Candida akadai Candida albicans. Zvimwe zvinokonzerwa zvinenge zvisinganyanyi kana zvisipo uye zvine ngozi toxicological profile.

Nifuratel (CAS: 4936-47-4) inorwisa antibacterial, antifungal, uye antiprotozoal nebasa rinorwisa Trichomonas.


2. Nifuratel Reviews-Technological Informationaasraw

Kemikari Name Nifuratel
CAS nhamba 4936-47-4
Molecular form C₁₀H₁₁N₃O₅S
Melting Point
176-178 ° C (chirevo)
Mol. Weight
285.28
chengetedzo
Hygroscopic, -20 ° C Freezer, Pasi mumhepo yakaoma
Solubility
Acetone (Zvishoma), Methanol (zvishoma)
Makemikari zvinhu Nifuratel - inopesana nokuputika, antibacterial agent inogadzirwa ne nitrofuran. The molecular mass of chemicals compound = 285,3 gramu pam mol. Chimwe chinhu chinobudiswa mumamapiritsi ekudya, Nifuratel chikamu chemakenduru nemafuta ekushandisa.
Pharmacodynamics uye pharmacokinetics Nifuratel - antibacterial agent wehuwandu hwemabasa. Zvinodhaka zvinoshanda pamagiramu-gram-positive uye gram-negative: stafilokokk, Citrobacter spp., Enterococcus faecium, salmonellas, Escherichia coli, klebsiyella, Enterococcus faecalis, Bacillus subtilis, Shigella flexneri, Enterobacter spp., Shigella sonnei, Serratia spp., Morganella spp., Pragia fontium, Rachnella aquatilis; lyambliya uye protozoa; Rettgerella spp., Budvicia aquatica, Acinetobacter spp ;; sarudza mhaswa Candida uye Trichomonas vaginalis.

Mishonga isinganyanyi kushanda maererano nePseudomonas aeruginos, Proteus mirabilis uye Proteus vulgaris.

Nifuratel Application Nifuratel chirwere chinoshandiswa se antibacterial, antifungal, antiprotozoal (Trichomonas). Nifuratel inoratidzika kuva ne-antibacterial spectrum yechiratidzo chekuita uye inoshanda kuburikidza neClamydia trachomatis uye Mycoplasma spp. pamwe nehutachiona hweFungal spp.


3. Nifuratel Dosageaasraw

Zvinodhaka zvinosarudzwa mukati. Zvichienderana nechirwere chirwere uye chirongwa chemishonga yakasiyana-siyana.
Nhamba yezuva nezuva yevakuru - kubva ku600 mg kusvika ku1,2 g. Nhamba yemishonga iyo mwana inoda kubvuma mukati mezuva inotarwa nemurairo we10-30 mg pahutengo kg.Kutanga kwehutano uye nguva yakawanda yekugamuchira kunoenderana nezviratidzo uye zvinorondedzerwa nechiremba anoenda. uye mafuta) inoshandisa maererano nekurudzirwa kwemuiti.


4. Nifuratel Application aasraw

Nifuratel (zita rechiratidzo Macmiror, kana-kusanganiswa ne nystatin, - Macmiror Complex) chirwere chinoshandiswa mumagynecology.

Nifuratel (zita rechiratidzo Macmiror, kana-rakabatanidzwa ne nystatin, - Macmiror Complex) inoshandiswa mumishonga inorwisa gynecology. Nifuratel Kushanda uye nifuratel usa, nifuratel uk


Nifuratel Application- "Macmiror complex"
1.Feature:
Yakavhiringidza chigadzirwa chekushandisa kwemukati mune gynecology, inosanganisira nitrofuran yakatorwa (nifuratel) uye mishonga inorwisa mabhakitiriya ye polyanov (nystatin).
2.Description chiito chemashambadziro:
Kurwisana neTrochomonas vaginalis uye Candida fungi, protozoa, gram-positive uye gram-negative microorganisms.
3.Mutemo wekushanda uye chirwere:
Chero zvinopesana nemashandisirwo emishonga panguva yekuzvitakura uye lactation (kunyamwisa) kwete.

Method of application and dose:

Vaginally, vasati vatavata - mukati memazuva 8 1 supp. kana 2.5 g yekamu 1-2 dzimwe nguva pazuva (uchishandisa mufambisi). Kana zvichidiwa, dzokorora mushonga mushure memwedzi.

Kuti uwane huwandu hwehutano hwehutachiona iwe unofanirwa kuisa iyo suppository kune chikamu chepamusoro chechikadzi.

Kudhengetedza kunoshandiswa kurapa muvana, zvinokurudzirwa kushandisa vaginal cream yakakwana neapplicator (akapedza seringe).

4.Special instructions:
Chirwere chekuita pamwe chete zvepabonde nekuda kwengozi yekuwanazve hutachiona. Penguva yekurapa inofanira kudzivisa vanoita zvepabonde.

Nzira yekushandisa shandisi yakapedza kudzidza: chengetedza mudzidzi wechikoro akazopedza kudzidza muhupu yekamu. Kuwana mukana wakafanira wekamu (maererano nemiganhu inoratidza kuwanda kwemagiramu), kusundira tube. Bvisai kubva muhubhu, vauye mumudzimai, shingai izvo zviri mukati, nekudzvinyirira pasi tsvimbo.

Bhuzi rinokosha rinokubvumira kupinda mukrimu usina kukuvadza iyo hymen. Zvakakosha kubvisa cannula kubva kumucheto wepamusoro wetsvimbo uye kuvharwa pamusoro weSirin kubva kune rumwe rutivi usati wasvika mukamu mumudzimai.


5. Nifuratel Migumisiro-Inoshanda Sei?aasraw

Nifuratel inogona kuuraya zvakajeka iyo mabhakitiriya, protozoa uye zvipembenene zvinotungamirira kumadzimai echirwere pasina chero chinhu chakaoma kana chisingaperi. Pamusana pemvura inonzi pleiotropic, nifuratel inogona kushandiswa kwemarudzi ose eve vaginitis anokonzerwa nemaabhakitiriya, trichomonas uye hutachiona hutachiona. Nifuratel, zvakasiyana-siyana zvema-antimicrobial agents ane maitiro maviri ekushandisa: muromo uye kunze kwekushandiswa, yakagadzirwa naDoppel Farmaceutici. S. rl rine zita rekutengeserana raMacmiror / Macmiror. Muna 2001, SFDA inobvumirwa nifuratel yakaitwa naDoppel Farmaceutici. S. rl kuti inotengeswa muChina nemhando dzakadai semaspiritsi ane shuga, mapiritsi emadzimai uye vaginal suppositories pasi pemabhizimisi mazita eMacmiror uye Macmiror Complex. Nifuratel madhara inokura nokukurumidza mushure mokupinda kuChina nekutengesa kwegore negore kubva kuCYY 53.2 mazana mu2005 kuCYY 38.03 mamiriyoni mu2014 neCAGR kusvika ku24.43% uye mamwe mabhizimisi eChina anove akatangawo kushandisa mishonga inogadzirwa.
Nekukurumidza kukura kwehupfumi hweChina uye nekuvandudzwa kwenyika yehutano inshuwarheni yehutano, marudzi mazhinji ezvinyorwa zvekuvhiringidza zvinodhaka, zvinotungamirirwa nemashoko matsva ekurapwa, zvakagadzirika kuvanhu vemazuva ose. Nenzira yakawanda, gynecological anti-infective misika mune zvipatara zvinoshandiswa inotungamirirwa nemishonga yemishonga inoshanda zvakakurumidza. Kune rumwe rutivi, mushonga weChina wechipatent wakaitwa nemabhizimisi emunharaunda anokundikana kupinda mumusika, pane kudaro, anoshandiswa zvakanyanya mumishonga yehutano hwemamai nemwana, masangano ekurapa ari munharaunda uye mumisika yekumaruwa.

(1) Migumisiro yeiifuratel pamusana wepabonde chechirwere chekuwedzera kupfurikidza neTTT uye koloni maitiro ekugadzirira

Kuti uongorore kushanda kweiifuratel pamunhu wemukati wemukenza mutsara yemasero, kushandiswa kwema cell kwakaongororwa neTTT testay. I-SGC-7901 uye BGC-823 mitsara yakarapwa neyanda kuwedzera yeiifuratel kwemaawa 48, uye kushandiswa kwesero kwakaongororwa neTTT testay. Zvinoguma muMufananidzo 1B zvinoratidza kuti kushanda kwema cell kwakadzingwa nenzira yakatarisana neipi-yei muSGC-7901 uye BGC-823 mutsara, neCI50 tsika dze 169.7 ± 2.2 μM muSGC-7901 masero uye 133.7 ± 0.85 μM muBGC- 823cells.
Uyewo, sezvinoratidzwa muMufananidzo 1C, uchienzaniswa nekutarisa masero, kupera kwechirwere chetachiona mumakoloni maitiro neSGC-7091 uye BGC-823 masero akaonekwa achishandiswa kuenzanisa kuenzanisa. Izvi zvinoratidza kuti nifuratel yakadzivisa zvikuru kukura uye kupararira kwevanhu gastric chemenza masero, zvichiita kuti serofu inouraya nenzira yakatarisana neipi.

(2) Nifuratel inokurudzira G2 / M sejeri kukasungwa mumasero ekenza yengarava yevanhu

Mufananidzo 2 Nifuratel inokurudzira G2 / M sejeri kukasungwa mumunhu wekenza yekenza masero.nifuratel usa uye nifuratel uk inonyanya kufarirwa.

Sero yekutenderera inzira inobatanidza ruzhinji rwezviitiko zvemasero zvinotungamirira kumasero ekuparadzanisa uye pakupedzisira pakupararira. Izvo yese sero rinogona kugoverwa muzvikamu zvina zvinosanganisira G1 sigaba, S sigaba, G2 phase, uye M chikamu (chikamu chekuparadzanisa) .20 Kuongorora kushandiswa kwemasero kushandiswa kune nifuratel, SGC-7901 uye BGC-823 masero dzakabatwa nifuratel kwemaawa 24. Nhamba yezana ye-nifuratel-yakarapwa uye isina kutorwa masero emukenza muG2 / M nharaunda yakayerwa nekuyerera kwechitometry. Sekuratidzwa muChifananidzo 2A uye B, nifuratel yakanyanyisa kukosha kusungwa kwemasero emukenza wemukati muG2 / M nhengo yesero rinopera kana ichienzaniswa neboka risina kutungamirirwa.
Nhamba: (A) Kuvhara kwemajeri ekumusungwa mumunhu wekenza yemukenza mutsva inotsvakurudzwa ne fl ow cytometry mushure mekurapa nehuwandu hwemaifuratel kwemaawa 24; DMSO inoshandiswa sekutakura kuraira. (B) Anomiririra histograms kubva pakuyerera kwechimetetry muvanhu vaviri vane kenza yemukenza yakagadziriswa nemhando dzakasiyana dzeiifuratel. Masayiri akaitwa mukatatu.

(3) Nifuratel inokurudzira apoptosis mumasero emukenza emunhu

Mufananidzo 3 Nifuratel-inokonzerwa apoptosis yemasero emukenza wegastric.nifuratel usa uye nifuratel uk inonyanya kufarirwa.

Kuti uongorore apoptosis-kukonzera kushanda kweiifuratel mumunhu wepachirwere chekenza mutsara, masero emukenza akabatwa ne nifuratel kwemaawa 24, akatariswa neAlexinini V-FITC uye PI, uye maapoptotic masero akaongororwa nekushambadza kwechitometry. Nhoroondo yacho yakaratidza kuti nifuratel dose-yakavhiringidzika sero cell apoptosis (Mufananidzo 3A). Mukuwedzera, nhoroondo yeWestern blot analysis yakaratidza zvakare kuti nifuratel yakawedzera kutaura kweproprooptotic protein Bax uye yakaderedza huwandu hweprotrot antiapoptotic Bcl-2 mumunhu masero emukenza wepamusoro nenzira inotarisirwa neipi (Mufananidzo 3B). Zviwanikwa zvedu zvakare zvakaratidza kuti nifuratel inogona kutonga kushandiswa kwesero rinouraya-zvine chokuita nemapuroteni, izvo zvinovhara chirongwa chevanhu gastric cancer chengetedza kupararira.
Mutsara: (A) SGC-7901 uye BGC-823 mitsetse yakatorwa nehutano hwemaifuratel hwemaawa e24 uye yakasvibiswa neAdinnin V uye propidium iodide. Zvigumisiro zvakaongororwa nekushambadzira kwechitometry. (B) Kuongorora kwakadzika kumadokero kweprotein yakabatana neepoptosis. Mutsara weBcl-2 neBaxin muSGC-7901 uye BGC-823 masero akayerwa neWestern blotting mushure mekuvharwa ne nifuratel kwemaawa 24.

(4) Nifuratel inhibits the STAT3 signaling pathway

Tsvakurudzo dzinoverengeka dzakaratidza kuti kuwedzera kwepuroteni ye STAT3 kunogona kusanganiswa nekufambira mberi kwekenza yemukati.21 Mitsva yedu yakaratidza kuti kurapwa ne 300 μM nifuratel kunowedzera kuderedza phosphorylated STAT3 (P-STAT3) puroteni muSGC-7901 neBGC -823 masero. Sekuratidzwa muChifananidzo 4, nifuratel yakaderera P-STAT3 protein kutaura muSGC-7901 uye BGC-823 masero emisero mumamiriro ekuchengetedza-mushure mushure mehutano hwemaawa 24. Zvinonzwisisika, iyo 300 μM inonzi nifuratel yakadererawo zvakanyanya P-STAT3 protein kutaura mushure memaawa 6 muSGC-7901 mitsara uye shure kwemaawa 3 mumasero eBGC-823.
Nhamba: (A) SGC-7901 uye BGC-823 mitsetse yakasungirirwa nehutano hwakanyanya hwe nifuratel, kutaura kweP-STAT3 kunoratidzwa neWest blot analysis. (B) Kutaura kweP-STAT3 nguva inotsvakirirwa nifuratel inoratidzwa neWest blot analysis muSGC-7901 uye BGC-823 masero.
Mitsanangudzo: DMSO, dimethyl sulfoxide; NIFU, nifuratel; STAT3, signal transducer uye activator yechinyorwa 3; P-STAT3, phosphorylated STAT3.
Zvinonyanya kukosha, chidzidzo chekare chakawana kuti IL-6-induced phosphorylation ya STAT3 mu neoplastic gastric tissue inobatanidzwa yakakonzerwa nekukura kwemuviri.22 Yakagadzirwa kuti IL-6-mediated activation ye STAT3 nzira yekucherechedza inogona kukurudzira kufambira mberi kweimwe kenza. 23,24 I STAT3 inhibitor yakadzivisa kushandiswa kwe STAT3, iyo inodzivisa nzira yekuisa chiratidzo yeLI-6 iyo ikakonzerwa nekenza cell proliferation, uye yakadzika pasi puroteni antiapoptotic Bcl-2.25 Nokudaro, kuti urambe uchijekesa kana nifuratel inogona kudzivisa phosphorylation yaI-6 inokonzerwa ne STAT3, isu takabatanidza kurapa naNifuratel uye IL-6. Mukuwedzera, napabucasin, iri mumuromo inowanikwa STAT3 inhibitor, yakashandiswa senhengo yakanaka yekudzora. Migumisiro yakaratidza kuti nifuratel inogona kudzivirira IL-6-induced activation ye STAT3 nzira yekuzaridzira, asi yakanga isina basa pakushanda kwe STAT1 yakapindirana ne-interferon-γ (IFN-γ) (Mufananidzo 5). Zvatabvunzurudza zvedu zvakare zvakaratidza kuti nifuratel yakarongedza kushandiswa kweprotein yeproteiniti yekufa-inonzi Bcl-2, yakaita kuti sero rekuvharwa kusvike, uye rakadzivisa kupararira kwevanhu gastric cancer cells kuburikidza neI-6-induced activation yemugwagwa we STAT3.
Nhamba: (A) Masero emukenza wegastric akambotariswa nehuwandu hwemaifuratel uye napabucasin kwemaawa 24 ndokuzosimudzirwa neI-6 (50 ng / μL) kwemaminitsi 30. Zvose-masero zviduku zvakagadzirirwa uye zvinowanikwa kuWestern blot analysis vachishandisa zviratidzo zvinoratidzwa. (B) Masero emukenza wegastric akafanirwa kutariswa nehuwandu hwemaifuratel kwemaawa 24 ndokuzosimudzirwa ne interferon-γ (IFN-γ) (50 ng / μL) kwemaminitsi 30. Zvose-masero zviduku zvakagadzirirwa uye zvinowanikwa kuWestern blot analysis vachishandisa zviratidzo zvinoratidzwa.
Mitsanangudzo: NIFU, nifuratel; Napa, napabucasin; P-STAT3, phosphorylated STAT3; STAT3, signal signal transducer uye activator yekunyora.

(5) Kushandisa nifuratel kurapa zvirwere zvinokonzerwa neve clostridium

Ikozvino inosanganisira kushandiswa kweiifuratel, kana kuti munyu wenyama inogamuchirwa, yekurapa zvirwere zvinokonzerwa neClostridium. Chirongwa ichi chinowanzonyorerwa kushandiswa kweiifuratel kubata chirwere cheClostridium difficile (CDI) uye kunyanya chirwere cheClostridium difficile chinosangana (CDAD).
Chinhu icho chiripo chiripo chinomiririrwa nifuratel, kana kuti munyu inogamuchirwa, iyo inoshandiswa mukurapa chero hutachiona hupi hunokonzerwa neClostridium, zvakadai seClostridium difficile, Clostridium butyricum uye Clostridium beijerinckii. Kunyanya kunyanya, inomiririrwa nekushandiswa kweiifuratel, kana kuti munyu unogamuchirwa muviri, yekurapa chirwere cheClostridium difficile (CDI) uye, kunyanya, Clostridium difficile inokonzerwa nehara (CDAD).
Yakasimba, yakasara-yakasimba kana yakagadzirirwa mvura yeinifuratel kana yewaini inogamuchirwa kwayo, nenzira yezvinyorwa zvemuromo, mahwendefa akafukidzwa nefirimu, capsules, dragées kana sirasi, ine zvinyorwa mu nifuratel kubva ku10 kusvika ku 1000 mg pamusi mumwe chete, kunyanya zvichida kubva ku50 kusvika ku800 mg mumwe musero mumwe chete, kunyanya zvichibva ku100 kusvika ku600 mg mumwe chete, inokodzera kurapa zvirwere neClostridium spp .; Kugadzirira kwakadaro kunogona kupiwa kune vane utachiona maererano nemararamiro anowanikwa; maererano nehutano hwakarongwa, dzinoshandiswa nguva dzose, zvichida katatu zuva nezuva. Mishonga yemishonga inogona kugadzirirwa maererano nemaitiro anowanzogadzirwa, inogona kunge ine mishonga inogamuchirwa, inogadzirisa uye / kana inotakura, uye inogonawo kuva, pamwe chete, imwe kana mamwe maitiro anobata pamwe neyokubatsirana kana, chero zvakadaro, basa rinobatsira.

Izvo zvinoshandiswa izvo zvinogona kushandiswa mukubatana ne nifuratel maererano nezvakagadzirwa zvino zvinosanganisira, asi hazvirevi kune, antibiotics, antidiarrheal agents uye probiotics; izvo zvinoshandiswa zvinoshanda zvinogona kuendeswa pamwe ne nifuratel (kureva kuti vangave sezviripo zviri mune zvakagadzirwa zvakafanana nifuratel) kana zvinogona kutarisirwa zvakasiyana nedzimwe nguva kana kuti kuswedera pedyo neiifuratel.
Mienzaniso yemishonga inorwisa mabhakitiriya inosanganisira metronidazole, vancomycin, bacitracine, rifaximine, aminoglycosides yakadai seyeomycin, gentamycin, amikacin, kanamycin uye marashi ayo.
Mienzaniso yevanorwara nehutachiona inosanganisira: bismuth subsalycilate, aluminium silicate, kaolin, yakagadzirwa nemarasha, loperamide, attapulgite, zinc. Mienzaniso yebiobioti inosanganisira marudzi ejenic Lactobacillus, Bacillus clausii uye Saccharomyces bouillardii. Mienzaniso yezvinyorwa zvakagadzirirwa maererano nezvakagadzirwa iye zvino zvinosanganisira: mahwendefa, mahwendefa akafukidzwa nefirimu, capsules, drages kana sirasi yakakodzera kunyora mumuromo.
Mishonga yemishonga uye kushandiswa kwezvakagadzirwa zvino zvichave zvakanyatsotsanangurwa zvizere nemuenzaniso unotevera. Izvi zvinofanira, zvisinei, zvichirangarirwa kuti mienzaniso yakadaro inopiwa nenzira yekufananidzira uye kwete yekuregererwa.


6. Nifuratel Side Effectsaasraw

GI kuvhiringidzika; peripheral neuropathy; thrombocytopenic purpura; haemolytic anemia kune varwere vane G6PD kukwana; hypersensitivity reaction; tsvaga dermatitis; hepatotoxicity; ropa dyscrasias; pulmonary reaction.
Chiratidzo ndiro izwi rinoshandiswa pakurongwa kwemamiriro ezvinhu kana zviratidzo kana zvirwere izvo mushonga unorayirwa kana kushandiswa nemurwere. Semuenzaniso, acetaminophen kana paracetamol inoshandiswa kufanana nefivha nemurwere, kana kuti chiremba anoritsanangurira musoro kana kurwadziwa kwemuviri. Iye zvino fivhiri, musoro uye kurwadziwa kwemuviri ndizvo zvinoratidza kuti paracetamol. Murwere anofanirwa kunge achiziva zviratidzo zvemishonga inoshandiswa kune zvinowanzoenderana nokuti inogona kutorwa pamusoro pekambani murasi yemishonga inoreva zvinoregererwa nemutapi.


7. Tenga Nifuratel Powder Onlineaasraw

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