Wepamusoro 7 Mishonga Yekurapa Lung Cancer-Yakagamuchirwa neDFA
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Lung Cancer

    1. Cancer Lung Cancer Chii?
    2. Ndeapi Mhando dzeCancer Lung?
    3. Ndezvipi Zviratidzo Kana Iwe Uine Kenza Yemapapu?
    4. Ndingaite Sei Kuti Ndizive Kana Ndine Lung Cancer?
    5. Ndeapi Matanho Eangu Kenza Kenza?
    6. Sei Ndine Kenza Yemapapu?
    7. Kurapa Kwako Kenza Kenza?

 

Cancer Lung Cancer Chii?

Gomarara rinogona kutanga chero nzvimbo mumuviri. Kenza inotangira mumapapu inonzi gomarara remapapu. Inotanga apo maseru mumapapu anokura kunze kwekudzora uye obatanidza masero akajairwa. Izvi zvinoita kuti zviomere muviri kuti ushande nenzira yaunofanira kuita.

Cancer masero anogona kupararira kune dzimwe nhengo dzomuviri. Cancer maseru mumapapu anogona dzimwe nguva kuenda kuuropi uye kukura ipapo. Kana masero ekenza achiita izvi, inonzi metastasis. Kune vanachiremba, masero egomarara munzvimbo nyowani anotaridzika senge anobva mupapu.

Gomarara rinogara richitumidzwa nzvimbo kwarinotangira. Saka apo kenza yemapapu inopararira kuuropi (kana chero imwe nzvimbo), ichiri kunzi kenza yemapapu. Haisi kunzi kenza yeuropi kunze kwekunge yatanga kubva kumasero ari muuropi.

Inocherechedzwa: Mapapu inhengo mbiri dzakaita sechipanji dzinowanikwa mubhokisi. Hapu yekurudyi ine zvikamu zvitatu zvinonzi makobvu. Mapapu ekuruboshwe ane maruva maviri. Mapapu anounza mweya mukati nekubuda mumuviri. Vanotora okisijeni uye vanobvisa carbon dioxide, tsvina chigadzirwa.

Mhepo, kana trachea, inounza mweya pasi mumapapu. Iyo inotsemuka kuita maviri machubhu anonzi bronchi (imwe chubhu inonzi bronchus).

 

Lung Cancer

Ndeapi Mhando dzeCancer Lung?

Kenza inotanga mumapapu inonzi primary cancer cancer. Gomarara rinopararira kumapapu kubva kune imwe nzvimbo mumuviri rinozivikanwa segomarara repiri remapapu. Iri peji ndere kenza yekutanga yemapapu.

Kune maviri epamusoro mafomu ekenza yemapapu kenza. Izvi zvinotsanangurwa nemhando yemasero umo kenza inotanga kukura. Vari:

Isiri-diki-sero kenza yemapapu (NSCLC) - iyo yakajairika fomu, kuverenga kweinopfuura 87% yematambudziko. Inogona kuve imwe yemhando nhatu: squamous cell carcinoma, adenocarcinoma kana hombe-sero carcinoma.

Diki-sero kenza yemapapu (SCLC) - fomu isingawanzo kujairika iyo inowanzopararira nekukurumidza kupfuura isiri-diki-sero kenza yemapapu.

Rudzi rwekenza yemapapu yaunotarisa kuti ndeapi marapirwo anokurudzirwa.

 

Ndezvipi Zviratidzo Kana Iwe Uine Kenza Yemapapu?

Vanhu vane kenza yemapapu vanogona kunge vasina chero zviratidzo kusvika padanho repashure. Kana zviratidzo zvikaonekwa, zvinogona kufanana neizvo zvehutachiona hwekufema.

 

Zvimwe zvinogona kuita Zviratidzo Zvakatendeseka zvinosanganisira:

Kuchinja kune izwi remunhu, sekushoshoma

▪ kutapukirwa kazhinji muchipfuva, senge bronchitis kana mabayo

▪ kuzvimba munzvimbo dzemukati mukati mechipfuva

▪ kukosora kwenguva refu kungatanga kuwedzera

▪ kurwadziwa pachipfuva

▪ kufema nekufema

 

Nekufamba kwenguva, munhu anogona zvakare kuona zviratidzo zvakanyanya, zvakadai se:

▪ kurwadziwa zvakanyanya muchipfuva

▪ kurwadziwa kwepfupa uye kutsemuka kwemabhonzo

▪ kutemwa nemusoro

▪ kukosora ropa

▪ kugwamba kweropa

▪ kuda kudya uye kuonda

▪ kuneta

 

Lung Cancer

 

Ndingaite Sei Kuti Ndizive Kana Ndine Lung Cancer?

Chiremba vanokubvunza mibvunzo nezve hutano hwako uye vanoongorora muviri. Kana zviratidzo zvichinongedzera kukenza yemapapu, mimwe miedzo ichaitwa

Heano mamwe emayedzo aungangoda:

Chest x-ray: Izvi zvinowanzo kuve bvunzo yekutanga inoitwa kutsvaga mabara pamapapu ako. Kana shanduko ikaonekwa, iwe uchazoda mimwe bvunzo.

CT scan: Iyi inonziwo CAT scan. Iyo yakasarudzika mhando ye x-ray iyo inotora yakadzama mifananidzo yeako mukati. CT scans inogona zvakare kushandiswa kubatsira kuita bhiopsy (ona pazasi).

PET scan: Mumuedzo uyu, unopihwa mhando yeshuga inoonekwa mukati memuviri wako ine kamera yakakosha. Kana paine kenza, shuga inoratidzika se "nzvimbo dzinopisa" panowanikwa kenza. Inogona kubatsira kana chiremba wako achifunga kuti kenza yapararira, asi asingazive kuti kupi.

Bronchoscopy: Chubhu yakatetepa, yakavhenekerwa, inochinjika inopfuudzwa nemumuromo mako kupinda mubronchi. Chiremba anogona kutarisa kuburikidza nehubhu kuti awane mamota. Iyo chubhu zvakare inogona kushandiswa kuita biopsy.

Kuyera ropa: Kuongororwa kweropa hakushandiswe kuwana cancer yemapapu, asi zvinoitirwa kuudza chiremba zvakawanda nezve hutano hwako.

 

Lung Cancer

 

Ndeapi Matanho Eangu Kenza Kenza?

Kana uine kenza isiri-diki yemapapu yemapapu, chiremba achada kuona kuti yapararira zvakadii. Uku kunodaidzwa kunzi staging. Iwe unogona kunge wakanzwa vamwe vanhu vachiti kenza yavo yaive "danho rechipiri" kana "danho rechitatu." Chiremba wako anozoda kutsvaga danho rekenza yako kuti abatsire kusarudza kuti nderupi rudzi rwekurapa kwakanakira iwe.

Chikamu chinotsanangura kupararira kwegomarara kuburikidza nemapapu. Inotaurirawo kana gomarara rapararira kunhengo dziri pedyo kana kunhengo dziri kure.

Chikamu chako chinogona kuve nhanho 1, 2, 3, kana 4. Iyo yakadzikira iyo nhamba, iko kushoma kenza kwapararira. Nhamba yepamusoro, senge danho rechina, zvinoreva kenza yakakomba yakapararira kunze kwemapapu ako. Ive neshuwa yekubvunza chiremba nezve kenza yako danho uye zvazvinoreva.

 

(1) Nhanho dzeiyo Isiri-Diki Cell Lung Cancer

Vashandi vezvehutano vanowanzo shandisa saizi kukura uye vanopararira kurondedzera iwo matanho easina-madiki maseru kenza yemapapu, seinotevera:

Zvemashiripiti, kana zvakavanzika: Gomarara hariratidzike pamifananidzo yekufungidzira, asi maseru ane gomarara anogona kuoneka mune phlegm kana masi.

Stage 0: Kune masero asina kujairika chete mumatunhu epamusoro emaseru anonamira mafafitera.

Stage 1: Bundu riripo mupapu, asi riri masendimita mana (cm) kana pasi uye harina kupararira kune dzimwe nhengo dzemuviri.

 Stage 2: Bundu iri 7 cm kana pasi uye rinogona kunge rakapararira kumatishu ari pedyo uye lymph node.

Stage 3: Kenza yakapararira kuma lymph node uye yakasvika kune mamwe matunhu emapapu nenzvimbo dzakatenderedza.

Stage 4: Kenza yakapararira kumativi emuviri ari kure, senge mapfupa kana huropi.

 

(2) Nhanho Of Small Ciye Lung Cancer

Kenza diki yemapapu yemapapu ine ayo zvikamu. Iwo matanho anozivikanwa seashoma uye akawandisa, uye iwo anoreva kana gomarara rapararira mukati kana kunze kwemapapu.

Muchikamu chakaganhurwa, gomarara rinobata chete divi rimwe rechipfuva, kunyangwe ringave riripo mune mamwe maLymph node. Vanenge chikamu chimwe muzvitatu chevanhu vane mhando iyi vanoona kuti vane gomarara kana riri muchikamu chakaganhurirwa. Vashandi vehutano vanogona kuibata neye radiation radiation senzvimbo imwe chete.

Muchikamu chakakura, kenza yakapararira kupfuura kune rumwe rutivi rwechifuva. Inogona kukanganisa mamwe mapapu kana zvimwe zvikamu zvemuviri. Vanenge zvikamu zviviri kubva muzvitatu zvevanhu vane kenza diki yemapapu yemapapu vanoona kuti vanayo kana yatove padanho rakakura.

 

Sei Ndine Kenza Yemapapu? 

Kenza inokura mushure mekukuvara kwemajini kuDNA uye epigenetic shanduko. Shanduko idzi dzinokanganisa mashandiro esero akajairika, kusanganisira kuwanda kwesero, yakagadzirirwa kufa kwesero (apoptosis), uye kugadzirisa DNA. Sezvo kukuvara kwakawanda kunowedzera, njodzi yekenza inowedzera.

Izvi zvikonzero zvinotungamira kukenza yemapapu manily:

Nei Ndine Kenza Yemapapu

 

 

▲ Kusvuta

Havasi vese vanosvuta vanowana kenza yemapapu, uye havazi vese vane cancer yemapapu vanosvuta. Asi hapana mubvunzo kuti kusvuta ndiyo hombe njodzi chinhu, zvichikonzera 9 kubva pa10Trusted Source mapapu ekenza. Pamusoro pefodya, fodya uye pombi kuputa zvinosanganiswa nekenza yemapapu. Paunonyanya kuputa uye nekureba uchisvuta, inowedzera mukana wako wekuva nekenza yemapapu.

Iwe haufanire kunge uri fodya kuti ubatwe. Kufema muhutsi hwevamwe vanhu kunowedzera mukana wekenza yemapapu. Maererano neCenters for Disease Control and Prevention CDC) Trusted Source, utsi hwefodya hunobata vanhu vanosvika zviuru mazana manomwe nemazana matatu vakafa mukenza yemapapu gore rega rega muUnited States.

Zvigadzirwa zvefodya zvine makemikari anodarika zviuru zvinomwe, uye makumi manomwe ndiwo anozivikanwa kuti anokonzera gomarara.

Paunofema utsi hwefodya, uyu musanganiswa wemakemikari unounzwa wakananga kumapapu ako, uko kwaunobva watanga kukonzera kukuvara.

Mapapu anowanzo gadzirisa zvinokuvadza pakutanga, asi kuenderera kwemhedzisiro pamapundu emapapu kunova kwakaoma kubata. Ndipo apo maseru akakuvara anogona kuchinja uye kukura kunze kwekudzora. Iwo makemikari aunofema anopindawo muropa rako uye anotakurwa mumuviri wako wese, ichiwedzera njodzi yemamwe marudzi ekenza. Vaimbova vaputi vachiri panjodzi yekuva nekenza yemapapu, asi kurega kunogona kudzikisira njodzi iyi zvakanyanya. Mukati memakore gumi ekurega, njodzi yekufa nekenza yemapapu inodonha nehafu.

 

Radhoni gasi

Radhoni igasi risina ruvara uye risinganetse rinogadzirwa nekuparara kweiyo radioactive radium, inovawo chigadzirwa chekuora cheuranium, inowanikwa muvhu repasi. Iko kuora kwemwaranzi zvigadzirwa zvinogadzirisa magene ezvechigadzirwa, zvichikonzera shanduko iyo dzimwe nguva inova cancer. Radon ndiyo yechipiri inonyanya kukonzeresa kenza yemapapu muUS, ichikonzera kufa kwevanhu zviuru makumi maviri nezviviri gore rega rega. Njodzi inowedzera kusvika pa21,000-8% pamazana zana eBq / m in inowedzera mukusungwa kweradhoni. Radon gasi mazinga anosiyana nenzvimbo uye kuumbwa. yevhu repasi nematombo. Inenge imwe chete mudzimba gumi neshanu muUS ine radon mazinga pamusoro peyakakurudzirwa nhungamiro yemapikicha mana litita (pCi / l) (16 Bq / m³).

 

Asbestos

Asbestos inogona kukonzera akasiyana siyana ezvirwere zvemapapu senge kenza yemapapu. Kusvuta fodya uye asbestosi zvese zvine hukama mukukudziridzwa kwekenza yemapapu. Mune vanoputa vanoshanda neasbestos, njodzi yekenza yemapapu inowedzerwa kanokwana makumi mana neshanu kana ichienzaniswa nevanhu vazhinji.Asbestos inogona kukonzeresa gomarara repura, inonzi mesothelioma - izvo chaizvo zvakasiyana nekenza yemapapu.

 

Kusvibiswa kwemhepo

Kunze kwemweya zvinosvibisa, kunyanya makemikari akaburitswa kubva mukutsva kwemafuta, zvinowedzera njodzi yekenza yemapapu. Mafuta akanaka (PM2.5) uye sulfate maaerosols, ayo anogona kuburitswa muutsi hwekutengesa traffic, ane hukama neyakawedzera-njodzi. Kune nitrogen dioxide, kuwedzera kwekuwedzera kwezvikamu gumi pabirioni kunowedzera mukana wekenza yemapapu ne10% .Kusvibisa kwemweya kwekunze kunofungidzirwa kukonzera 14-1% yemakenza emapapu.

Uchapupu hwekufungidzira hunotsigira njodzi yakawedzera yekenza yemapapu kubva mukushatiswa kwemhepo yemukati zvine chekuita nekupiswa kwehuni, marasha, ndove, kana zvisaririra zvezvirimwa pakubika nekupisa. Vakadzi vanoratidzwa hutsi hwemumba hwemukati vane njodzi yakapetwa kaviri, uye mazhinji Iyi njodzi inobata vanhu vangangoita mabhiriyoni maviri nemazana mana pasi rese, uye inofungidzirwa kuti inokonzeresa 2.4% yenzufu dzemukenza yemapapu.

 

Genetics

Inenge 8% yekenza yemapapu inokonzerwa nezvinhu zvakagarwa nhaka Muhukama hwevanhu vanoonekwa kuti vane kenza yemapapu, njodzi inopetwa kaviri, pamwe nekuda kwekusanganiswa kwemajini. Polymorphisms pama chromosomes 5, 6, uye 15 anozivikanwa kuti anokanganisa Imwe-nucleotide polymorphisms (SNPs) yemageneti anonamira nicotinic acetylcholine receptor (nAChR) - CHRNA5, CHRNA3, uye CHRNB4 - ndeavo vanobatanidzwa nenjodzi yakawedzera yekenza yemapapu, pamwe neRGS17 - geni kudzora G-protein siginecha.

 

mwe zvikonzero

Zvimwe zvinhu zvakawanda, mabasa, uye kuratidzwa kwezvakatipoteredza zvakabatanidzwa nekenza yemapapu. Sangano reInternational Agency for Research on Cancer (IARC) rinoti pane humwe "humbowo hwakakwana" kuratidza kuti zvinotevera zvinokonzeresa mumapapu:

Zvimwe simbi (aluminium kugadzirwa, cadmium uye cadmium makomponi, chromium (VI) makomputa, beryllium uye beryllium makomponi, simbi nesimbi kuvamba, nickel makomputa, arsenic uye inorganic arsenic makomponi, uye pasi pevhu hematite kuchera

Mimwe michina yemoto (isina kukwana kupisa, marasha (emukati emhepo kubva kumoto wemarasha unopisa), marasha gasification, marasha-tara pombi, kugadzirwa kwecoke, sosi, uye dhiziri injini chiutsi)

Ionizing radiation (X-ray uye gamma).

Mamwe magasi ane chepfu (methyl ether (technical grade), uye bis- (chloromethyl) ether, sarufa masardard, MOPP (vincristine-prednisone-nitrogen mustard-procarbazine musanganiswa) uye utsi kubva kupenda)

Kugadzirwa kwerabha uye nekristaro silica guruva.

Pane kuwedzera kudiki mungozi yekenza yemapapu muvanhu vanobatwa ne systemic sclerosis.

 

Kurapa Kwako Kenza Kenza? 

Kune nzira dzakawanda dzekurapa kenza yemapapu. Kuvhiya nemwaranzi zvinoshandiswa kurapa gomarara chete. Izvo hazvikanganisa iyo yakasara yemuviri. Chemo zvinodhaka, zvakanangwa kurapa, uye immunotherapy zvinopinda nemuviri wese. Vanogona kusvika masero ekenza chero kupi zvako mumuviri.

 

Kurapa kwekenza yemapapu kunogona kusanganisira kuvhiya, radiation, chemotherapy, yakanangwa kurapwa, uye immunotherapy. Chirongwa chekurapa chakanakira iwe chinoenderana ne:

▪ Chikamu chegomarara

▪ Mukana wekuti marapirwo erudzi achabatsira

▪ Zera rako

▪ Mamwe matambudziko ehutano aunayo

▪ Kunzwa kwako pamusoro pekurapwa uye nemhedzisiro inogona kuuya napo.

 

Lung Cancer

 

Varwere vazhinji vane kenza yemapapu vanosarudza drug therapy mune yekutanga nhanho, nekuti ndiyo yakatwasuka uye yakapusa nzira yekudzora kupararira kwemakenza maseru. Iyi inotevera mishonga inowanzo shandiswa kurapa kenza yemapapu (SCLC neNSCLC):

 

❶ AZD-3759 (CAS: 1626387-80-1)

AZD-3759 yakasimba epidermal kukura chinhu chinogamuchira (EGFR) inhibitor, iine antineoplastic chiitiko. AZD-3759 inosunga uye inodzivirira chiitiko cheEGFR pamwe nemimwe miitiro yekuchinja yeEGFR Izvi zvinodzivirira kusaina-kugadziriswa kweEGFR, uye kunogona kutungamira kune ese ari maviri induction maseru uye kuvharika kwemota kukura muESG-overexpressing masero.

Kenza yemaperembudzi zvinodhaka AZD 3759

 

❷ Gefitinib (CAS: 184475-35-2)

Gefitinib is tyrosine kinase inhibitor inoshandiswa senzira yekutanga-kurapa kurapa isiri-diki sero lung carcinoma (NSCLC) inosangana neakasarudzika maitiro ekuchinja.

Gefitinib is inhibitor yeiyo epidermal kukura factor receptor (EGFR) tyrosine kinase inosunga kune adenosine triphosphate (ATP) - inosunga saiti yeiyo enzyme. EGFR inowanzo kuratidzwa kuve yakanyanya kufungidzirwa mune mamwe maseru evanhu ecarcinoma, senge mapapu uye kenza yemazamu maseru. Kunyanyisa kuratidza kunotungamira mukumisikidzwa kweiyo anti-apoptotic Ras chiratidzo transduction macashure, zvichizoguma nekuwedzera kupona kwemaseru ekenza uye kusadzora kuwanda kwesero. Gefitinib ndiyo yekutanga inosarudza inhibitor yeEGFR tyrosine kinase iyo inonziwo Her1 kana ErbB-1. Nekudzivirira EGFR tyrosine kinase, iyo yekudzika yekuisa chiratidzo macascades aka dzivirirwawo, zvichikonzera kudzivirirwa kwakaipisisa kwemasero kuwanda.

 

AZD-9291(CAS: 1421373-65-0)

AZD-9291 inonzi zvakare Osimertinib inova tyrosine kinase inhibitor inoshandiswa mukurapa mamwe marudzi easina-madiki maseru mapapu carcinoma.

AZD-9291 iyo epidermal yekukura factor receptor (EGFR) tyrosine kinase inhibitor (TKI) inosunga kune mamwe mutant mafomu eEGFR (T790M, L858R, uye exon 19 kubviswa) ayo anowanikwa mune isiri-diki sero kenza yemapapu yemapapu (NSCLC) mamota anotevera kurapwa nekutanga -nzira EGFR-TKIs. Sechizvarwa chechitatu-tyrosine kinase inhibitor, AZD-9291 yakanangana nemusuo-muchengeti T790M mutation inowedzera ATP inosunga chiitiko kune EGFR uye inoguma nehurombo hwekufungidzira kweanononoka-nhanho chirwere. Uyezve, AZD-9291 yakaratidzirwa kuchengetedza yemhando-yemhando EGFR panguva yekurapa, nokudaro ichideredza isiri-yakatarwa inosunga uye kudzikisira huturu.

Kenza yemaperembudzi zvinodhaka AZD 9291

 

Acom Dacomitinib (CAS: 1110813-31-4)

Dacomitinib mushonga unoshandiswa kurapa isiri diki kenza yemapapu kenza neEGFR exon 19 kubviswa kweexon 21 L858R kutsiva. Dacomitinib, yakagadzirirwa se (2E) -N-16-4- (piperidin-1-yl) asi-2-enamide, inotaurwa inonyatsosarudza quinazalone chikamu chechipiri-chizvarwa tyrosine kinase inhibitors iyo inozivikanwa nekusadzoreka kusunga pa iyo ATP dhata yeiyo epidermal yekukura factor receptor mhuri kinase domains. Dacomitinib imishonga yekurapa isiri-diki-cell lung carcinoma (NSCLC). Iyo inosarudza uye isingadzoreke inhibitor yeEGFR.

 

❺ Ceritinib (CAS: 1032900-25-6)

Ceritinib inonziwo LDK378 iyo inonzi antineoplastic kinase inhibitor inoshandiswa kurapa anaplastic lymphoma kinase (ALK) -positive metastatic non-small cell lung cancer (NSCLC) mune varwere vasina kukwana kukiriniki kupindura kana kusashivirira kune crizotinib.

Ceritinib inoshandiswa pakurapa vanhu vakuru vane anaplastic lymphoma kinase (ALK) -positive metastatic non-small cell lung cancer (NSCLC) zvichitevera kutadza (kwechipiri kuramba kana kusashivirira) kwekutanga crizotinib kurapa. Vanenge 4% yevarwere vane NSCLC vane chromosomal rearrangement iyo inogadzira fusion gene pakati peEML4 (echinoderm microtubule-inosanganisirwa protein-senge 4) uye ALK (anaplastic lymphoma kinase), iyo inoguma nekuita kwechiase kinase chiitiko chinopa kune carcinogenesis uye inoita kunge inotyaira iyo yakaipa phenotype. Ceritinib ine simba rayo rekurapa nekudzivirira autophosphorylation yeALK, ALK-yakagadziriswa phosphorylation yepasi yekuratidzira protein STAT3, uye kuwanda kwema ALK-anoenderana nekenza maseru emukenza. Kutevera kurapwa ne crizotinib (chizvarwa chekutanga ALK inhibitor), mabundu mazhinji anokudziridza kupokana nemushonga nekuda kwekuchinja mumakiyi anokosha e "muchengeti wesuo" eiyo enzyme. Izvi zvinoitika zvakakonzera kukura kweruzivo rwechipiri-chizvarwa ALK inhibitors senge ceritinib kukurira crizotinib kuramba. Iyo FDA yakabvumidza ceritinib muna Kubvumbi 2014 nekuda kwekushamisa kunoshamisa kwekupindura mwero (56%) yakanangana crizotinib-mumiririri mamota uye akaisarudzira nenherera chinzvimbo chinodhaka.

 

Atin Afatinib (CAS: 439081-18-2)

Afatinib inorwisa antineoplastic mumiririri inoshandiswa pakurapa kenza yemukenza yemapapu (NSCLC) yemuno isina-diki kana isingagadzirike shanduko yeEGFR kana kuramba platinum-based chemotherapy.

Afatinib iri 4-anilinoquinazoline tyrosine kinase inhibitor muchimiro chemunyu wedimate unowanikwa sezita raBoehringer Ingelheim zita rekuti Gilotrif. Zvekushandisa nemuromo, afatinib mahwendefa ari ekutanga-mutsetse (kutanga) kurapwa kwevarwere vane metastatic isiri-diki maseru kenza yemapapu (NSCLC) ine zvakajairika epidermal kukura factor receptor (EGFR) shanduko sezvinoonekwa nemuedzo unobvumidzwa neDAFA 4. Gilotrif ( afatinib) ndiyo yekutanga FDA-inogamuchirwa oncology chigadzirwa kubva kuBoehringer Ingelheim.

 

Lot Erlotinib (CAS: 183321-74-6)

Erlotinib ndeye EGFR tyrosine kinase inhibitor yaishandiswa kurapa mamwe madiki maseru ekenza emapapu kana epamberi metastatic pancreatic cancer. Icho chiri chekirasi yemishonga inozivikanwa se tyrosine kinase inhibitors. Inoshanda nekudzivirira kushanda kweprotein inonzi epidermal kukura factor receptor (EGFR). EGFR inowanikwa pamusoro pemasero mazhinji egomarara pamwe nemasero akajairwa. Inoshanda se "kanyanga," ichigamuchira zviratidzo kubva kune mamwe maseru uye nharaunda inotaurira sero kuti ikure uye ipatsanure. Iyo EGFR inoita basa rakakosha mukukura uye kukura prenatally uye panguva yehucheche uye inobatsira kuchengetedza zvakajairwa kutsiva kwemaakare uye akakuvara maseru muvakuru. Zvisinei, masero emukenza mazhinji ane huwandu husingaenzanisike hweEGFR pamusoro payo, kana EGFR yavo yakashandurwa nekuchinja kweDNA inotakura iyo genetic kodhi yeproteine. Mhedzisiro yacho ndeyekuti zviratidzo zvinouya kubva kuEGFR zvakanyanyisa kusimba, zvichitungamira mukuwandisa kwesero kukura uye kupatsanurwa, chiratidzo checancer.

Yese mishonga iyi inogona kupihwa ne aasraw mune yakachena poda fomu, inova chete yekutsvaga chinangwa. Kugamuchirwa kuti utaure neaasraw kana iwe uchida kuziva rumwe ruzivo nezvekuti ungatenga sei aganist kenza yemapapu zvinodhaka!

 

Reference

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