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Nicotinamide riboside chloride

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MUTSVENE une mukana wekupa anti-kukwegura zvigadzirwa-NRC Powder yakawanda neCGMP mutemo uye neinoteedzera mhando yekudzora mhando. Yedu yepakati kugadzirwa kwemwedzi inogona kusvika 2100kg. Kugamuchirwa kuti utaure nesu kuti uwane rumwe ruzivo rwekutenga:
Mamiriro: Mudura

Mapakeji Unit: 1kg / bhegi, 25kg / dhiramu

Product Description

Basic Hunhu

Product Name Nicotinamide riboside chloride
CAS Number 23111-00-4
Molecular Formula C11H15ClN2O5
Formula Weight 290.7
Synonyms 23111-00-4

Nicotinamide riboside chloride

Nicotinamide riboside (chloride)

3-Carbamoyl-1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride

Nicotinamide ribose chloride

Kuonekwa White powder
Kuchengeta uye Kubata 0 - 4 C kwenguva pfupi (mazuva kusvika kumavhiki), kana -20 C kwenguva refu (mwedzi).

 

Nicotinamide riboside chloride Tsanangudzo

Nicotinamide Riboside Chloride (NIAGEN) ndiyo chloride munyu fomu ye nicotinamide riboside (NR) .NR ndiyo fomu nyowani pyridine-nucleoside yevhitamini B3 inoshanda seyakatangira kune nicotinamide adenine dinucleotide (NAD) kana NAD + .NIAGEN inowanzozivikanwa seyakachengeteka (GRAS) muUnited States yekushandisa muzvigadzirwa zvekudya. Nicotinamide riboside chloride inzira yekristaro yeNicotinamide riboside (NR) chloride. Nicotinamide riboside chloride inowedzera NAD [+] mazinga uye inoita SIRT1 uye SIRT3, inoguma mukusimudzira oxidative metabolism uye kudzivirirwa kubva kune yakawanda mafuta chikafu-inosimudzira metabolic kusakanganisika. Nicotinamide riboside chloride powder inoshandiswa mune zvekudya zvinowedzera.

 

Nicotinamide riboside chloride Maitiro Ekuita

Nicotinamide Riboside Chloride (NIAGEN) ndiyo chloride fomu yemunyu yeNicotinamide riboside (NR). NR ndeye pyridine-nucleoside fomu yevhitamini B3 inoshanda sepamberi kune nicotinamide adenine dinucleotide kana NAD +. NR inovhara kuora kwekuvhiya kwakatemwa dorsal midzi ganglion neurons ex vivo uye inodzivirira kurira-kunokonzera kurasikirwa kwekunzwa mumakonzo mhenyu. Nicotinamide riboside powder inodzivirira mhasuru, neural uye melanocyte stem cell senescence. Kuwedzera kwemhasuru kumutsiridzwa mumakonzo kwave kuchionekwa mushure mekurapwa nicotinamide riboside, zvichitungamira mukufungidzira kuti zvinogona kuvandudza kumutsiridzwa kwenhengo dzakadai sechiropa, itsvo, nemoyo. Nicotinamide riboside inoderedza shuga yeropa uye mafuta ane chiropa mu prediabetic uye mhando 2 yeshuga modhi ichidzivirira kukura kwechirwere cheshuga peripheral neuropathy. Tarira: Nicotinamide Riboside chloride isanganiswa ye α / β.

 

Nicotinamide riboside chloride Kunyorera

Nicotinamide riboside chloride powder yakanyoreswa neCAS nhamba 23111‐00‐4 uye EC nhamba 807‐820. IUPAC zita rayo 5 - [(1R, 2R, 3S, 4R) ‐5 ‐ dihydroxy ‐ 3,4‐ (hydroxymethyl) oxolan ‐ 5 l yl] pyridin ‐ 2 ‐ ium ‐ 1 ‐ carboxamide; chloride. Iyo molecular fomula yeNicotinamide riboside chloride ndeye C3H11N15O2Cl, uye yayo mamorekuru uremu 5 g / mol. Nicotinamide Riboside Chloride (NIAGEN) ndiyo chloride munyu fomu ye nicotinamide riboside (NR) .NR ndiyo fomu nyowani pyridine-nucleoside yevhitamini B290.7 inoshanda seyakatangira kune nicotinamide adenine dinucleotide (NAD) kana NAD +. Muviri unoda NAD + kuti ushande zvakajairika. Kuderera kweNAD + kunogona kukonzera matambudziko ekurapa. Kutora nicotinamide riboside kunogona kubatsira kukwidza aya akaderera NAD + nhanho.

 

kubatsira Nicotinamide riboside chloride

Nicotinamide riboside Chloride, inoitwa nemuromo NAD + inotungamira, inowedzera NAD + nhanho uye inoita SIRT1 uye SIRT3. Nicotinamide riboside Chloride powder ndiko kunobva vhitamini B3 (niacin) uye shandisa Nicotinamide riboside Chloride powder inogona kuwedzera oxidative metabolism, kudzivirirwa kubva kune yakawanda mafuta chikafu-inokonzera metabolic kusakanganisika. Nicotinamide riboside Chloride inoderedza kusanzwisisika kwekusanzwisisika mune inoshanduka mbeva modhi yechirwere cheAlzheimer.

 

Reference

[1] Chi Y, Sauve AA. Nicotinamide riboside, inoteedzera zvinovaka zvinovaka mukudya, ivhitamini B3 ine zviga zvine simba metabolism uye neuroprotection. Curr Opin Clin Nutr Metab Care. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Ongorora. PubMed PMID: 24071780.

[2] Bogan KL, Brenner C. Nicotinic acid, nicotinamide, uye nicotinamide riboside: mamorekuru kuongororwa kweNAD + preursor mavitamini muhutano hwevanhu. Annu Rev Nutriti. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Ongorora. PubMed PMID: 18429699.

[3] Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation seyero-yechipenga, mutyairi wekushanduka kwemafuta ekuchengetedza: kemikari uye metabolic pfungwa yeacetyl-lysine kugadziridzwa. Crit Rev Biochem Mol Biol. 2013 Mbudzi-Zvita; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Ongorora. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.

[4] Yang Y, Sauve AA. NAD (+) metabolism: Bioenergetics, kusaina uye kumanikidza kurapa. Biochim Biophys Acta. 2016 Dec; 1864 (12): 1787-1800. doi: 10.1016 / j.bbapap.2016.06.014. Ongorora. PubMed PMID: 27374990.

[5] Sauve AA. NAD + uye vitamini B3: kubva pametabolism kuenda pakurapa. J Chemishonga Exp Ther. 2008 Kurume; 324 (3): 883-93. doi: 10.1124 / jpet.107.120758. Ongorora. PubMed PMID: 18165311.

[6] Kato M, Lin SJ. Mutemo weNAD + metabolism, kuisa chiratidzo uye kupatsanurwa mune mbiriso Saccharomyces cerevisiae. DNA Kugadzirisa (Amst). 2014 Mbudzi; 23: 49-58. doi: 10.1016 / j.dnarep.2014.07.009. Ongorora. PubMed PMID: 25096760; PubMed Central PMCID: PMC4254062.

[7] Cantó C, et al. Iyo NAD (+) yekumberi nicotinamide riboside inowedzera oxidative metabolism uye inodzivirira kune yakakwira-mafuta kudya-kunokonzera kufutisa. Cell Metab. 2012 Jun 6; 15 (6): 838-47.

[8] Bing Gong, et al. Nicotinamide Riboside Inodzosera Kuziva Kuburikidza neKugadziriswa kweProliferator-Yakagadziriswa Receptor-γ Coactivator 1A Yakagadziriswa β-Secretase 1 Kudzikisira uye Mitochondrial Gene Kuratidzira muAlzheimer's Mouse Models. Neurobiol Kukwegura. 2013 Jun; 34 (6): 1581-8.

[9] Collin D Heer, et al. Coronavirus uye PARP Tsananguro Dysregulate iyo NAD Metabolome: Chinhu Chinogoneka Chinogoneka cheInitate Immunity bioRxiv. 2020 Kubvumbi 30; 2020.04.17.047480.