(CAS 681136-29-8) N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide upfu | AASRAW
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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video

 

 


 

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters

 

Name: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Kuchena: ≥99% (HPLC)
Synonyms: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Molecular Formula: C19H19N5OS
Molecular Kurema: 365.459
Nheyo yakanyunguduka: 240.48
Dhikirai: 559.69 ° C pa 760 mmHg
Kuwandisa: ~ 1.3 g / cm3
Storage Temp: Chengeta pa + 4 ° C
Solubility: DMSO: ≥28mg / mL
Refractive index: n20D 1.68
Color: A crystalline yakasimba
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChI Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N

 


 

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Kushandiswa kwepodha mumhepo

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N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid upfu, JNJ 166101 Powder

Basa iri sei paN-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Kushandiswa kwepoda

FAAH preincubated pamwe JNJ1661010 rinoratidza kunonoka reversibility ari kudyidzana pakati JNJ1661010 uye kushingaira nzvimbo, iyo nokukurumidza pana kukwira. JNJ-1661010 inofanana, inogadziriswa-substrate inhibitor yakaongororwa naLC-ESI-MS. JNJ-1661010 nechiteshi chengarava pamwe phenylthiadiazole ari hydrophobic mugero uye phenylurea iri hydrophilic muhomwe FAAH, JNJ-1661010 (20 MG / makirogiramu Rinozvikudza ip) kuchititadzisa FAAH kubudikidza anenge 85% kusvika 4 H pashure dosing, zvichiita kuunganidza lipid ethanolamides muhuropi hwechikwata. JNJ-1661010 dose-dependently kudzokera kuti tactile allodynia ane kunonyanyisa efficacy kweinenge 90% pa 30 Maminitsi postdose zvose Nounyoro Thermal Injury (MTI) makonzo uye gonzo womuenzaniso. JNJ-1661010 (20 mg / kg) inodzokorora tactile allodynia ne 60.8% pa 30 min mukoko yepal spinal nerve ligation yokukuvadza. JNJ-1661010 (50 MG / makirogiramu Rinozvikudza ip) inoratidza chinokosha attenuation pamusoro hyperalgesia pana 30 Maminitsi postdose mu gonzo carrageenan muenzaniso anogumbura marwadzo.
Makonzo dosed pamwe JNJ-1661010 (20 MG / makirogiramu Rinozvikudza ip) ane yeplasma Cmax pamusoro 26.9 μM panguva Tmax pamusoro 0.75 H uye Cmax mu uropi 6.04 μM panguva Tmax pamusoro 2 h. JNJ-1661010 (20 mg / kg ip) inhibitsvo uropi FAAH uye inosimudza chiyero cheAEA mumakumbo europi mumakonzo.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder

Min order 10grams.
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