Acalabrutinib powder (ACP-196) - Mugadziri Fekitori Mutengesi
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Acalabrutinib (ACP-196)

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Acalabrutinib powder, inozivikanwawo se ACP-196, inoverengeka isingadzoreke yechipiri-chizvarwa Bruton's tyrosine kinase (BTK) inhibitor, iyo inodzivirira kumisikidzwa kweB-cell antigen receptor (BCR) yekuratidzira nzira uye iyo, yaive yakagadziriswa kuti ive yakawanda zvine simba uye zvinosarudzika kupfuura ibrutinib.

Product Description

Basic Hunhu

Product Name Acalabrutinib upfu (ACP-196)
CAS Number 1420477-60-6
Molecular Formula C26H23N7O2
Formula Weight 465.5
Synonyms Acalabrutinib upfu;

1420477-60-6;

ACP-196;

Kuverenga;

UNII-I42748ELQW.

Kuonekwa Poda yakasviba (Tea ruvara)
Kuchengeta uye Kubata Chengetera mumudziyo wakavharwa pane tembiricha yemukati, kure nekupisa, hunyoro, uye mwenje wakananga. Ramba uchitonhora.

 

Acalabrutinib Powder (ACP-196) Tsananguro

Acalabrutinib powder, inozivikanwawo se ACP-196, inoverengeka isingadzoreke yechipiri-chizvarwa Bruton's tyrosine kinase (BTK) inhibitor, iyo inodzivirira kumisikidzwa kweB-cell antigen receptor (BCR) yekuratidzira nzira uye iyo, yaive yakagadziriswa kuti ive yakawanda zvine simba uye zvinosarudzika kupfuura ibrutinib. Uyu mushonga mumakiriniki ekuyedza chikamu chechitatu chekurapwa kurapwa kweakadzokororwa chisingaperi chingava neropa. Zvakare mukubatana nevamwe zvinodhaka, Acalabrutinib powder muchikamu chechipiri chemakiriniki ekuedzwa kwekurapa Glioblastoma Multiforme, Mantle Cell Lymphoma, Squamous Cell Carcinoma yeMusoro neNeck, Rheumatoid Arthritis nevamwewo.

 

Acalabrutinib Powder (ACP-196) Maitiro Ekuita

Acalabrutinib powder idiki mamorekuru inhibitor yeBTK. Ose acalabrutinib powder uye ayo anoshanda metabolite, ACP-5862, inoita kugadzira covalent bond necysteine ​​residue (Cys481) mune BTK inoshanda saiti, zvichitungamira mukudziviswa kweBTK enzymatic chiitiko. yemapuroteni ekuratidzira ari pasi pemvura CD86 neCD69, ayo anozopedzisira avhiringidza kuwanda kweB-cell kupararira uye kurarama

Ipo ibrutinib inowanzozivikanwa seyekutanga-mukirasi BTK inhibitor, acalabrutinib powder inoonekwa sechizvarwa chechipiri BTK inhibitor kunyanya nekuti inoratidza kusarudzika uye kuvharidzira kwechiitiko chakanangwa cheBTK ichine IC50 yakakura kana neimwe nzira pasina kuvharirwa iyo kinase zviitiko zveITK, EGFR, ERBB, ERBB4, JAK3, BLK, FGR, FYN, HCK, LCK, LYN, SRC, uye YES1.

Chaizvoizvo, acalabrutinib powder yaive yakagadziriswa kuti ive yakasimba uye inosarudzika kupfuura ibrutinib, nguva yese iyi ichiratidza mashoma mhedzisiro - murondedzero - nekuda kwechinoderedzwa chakaderedzwa kubva pane zvinangwa.

 

Acalabrutinib Powder (ACP-196) Kushanda

Acalabrutinib powder inoshandiswa kurapa vanhu vane mantle cell lymphoma (MCL; kenza inokura nekukurumidza inotanga mumasero ezvirwere zvemuviri) avo vakatorapwa nechero imwe chemotherapy mishonga. Inoshandiswawo yoga kana neobinutuzumab (Gazyva) kurapa chirwere cheLymphocytic leukemia (CLL; rudzi rwekenza inotanga mumasero machena eropa) uye diki lymphocytic lymphoma (SLL: rudzi rwekenza inotanga mumasero machena eropa) . Acalabrutinib powder iri mukirasi yemishonga inonzi kinase inhibitors. Inoshanda nekudzivirira chiito cheprotein isina kujairika iyo inoratidza masero ekenza kuti iwande. Izvi zvinobatsira kumisa kupararira kwekenza masero.

 

Acalabrutinib Powder (ACP-196) Side Migumisiro & Yambiro

Pamwe pamwe nezvinodiwa zvawo, mushonga unogona kukonzeresa zvimwe zvisingadiwe. Kunyangwe zvisiri zvese izvi mhedzisiro zvinogona kuitika, kana zvikazoitika vangangoda kurapwa.

Tarisa nachiremba wako nekukurumidza kana paine anotevera mhedzisiro mhedzisiro anoitika:

 

Zvimwe zvakajairika

▪ matadza achibuda ropa

▪ kuunganidzwa kweropa pasi peganda

▪ kukosora ropa

▪ kunetseka kufema kana kumedza

▪ dzungu

▪ kutemwa nemusoro

Kuwedzera kuenda kumwedzi kana kubuda ropa muchikadzi

▪ kuvaviwa, kurwadziwa, kutsvuka, kana kuzvimba

▪ zvigamba zvihombe, zvakapfava, zvebhuruu kana zvepepuru paganda

▪ kubuda ropa mumhino

▪ kuoma mutezo

▪ kubuda ropa kwenguva refu kubva mukucheka

▪ tsvuku kana nhema, zvituru zvekugara

▪ weti tsvuku kana yakasviba

Mimwe mhedzisiro inogona kuitika iyo kazhinji isingade kurapwa. Iyi mhedzisiro inogona kuenda panguva yekurapa sezvo muviri wako unogadzirisa kumushonga. Zvakare, wako wezvehutano wezvehutano anogona kunge achikwanisa kukuudza nezvenzira dzekudzivirira kana kudzikisira mimwe yemhedzisiro iyi. Tarisa neunyanzvi hwako hwekuchengetedza hutano kana paine anotevera mhedzisiro anoenderera mberi kana ari kunetsa kana kana iwe uine chero mibvunzo nezvawo:

 

Zvimwe zvakajairika

▪ kupatirwa

▪ manyoka

▪ kunetseka kufamba

▪ kurwadza kwemajoini kana kuzvimba

▪ kugwinha kwemhasuru, kurwadziwa, kana kuomarara

▪ kusvotwa

▪ mapundu

▪ kurwadziwa nemudumbu

▪ kuneta kana kushaya simba kunoshamisa

▪ kurutsa

Mimwe mhedzisiro isina kunyorwa inogona kuitikawo kune vamwe varwere. Kana iwe ukaona chero mimwe mhedzisiro, bvunza neyako nyanzvi yehutano. Dana chiremba wako kuti akupe mazano ekurapa nezvemigumisiro. Unogona kuzivisa mhedzisiro kuDAA pa1-800-FDA-1088.

 

Reference

[1] Fischer K Al-Sawaf O Bahlo J et al. Venetoclax uye obinutuzumab mune varwere vane CLL uye mamiriro ezvinhu aripo. N Engl J Med. 2019; 380: 2225-2236.

[2] Imba DW (2016-02-25). "AstraZeneca uye Acerta Pharma's acalabrutinib powder yakamaka Orphan Drug muEurope nezviratidzo zvitatu". Kutsvaga Alpha. Yakadzorerwa 2016-11-21.

[3] "EU / 3/16/1626". European Medicines Agency (EMA). 4 May 2016. Yakadzorerwa 15 Kubvumbi 2020.

[4] Byrd JC, Harrington B, O'Brien S, Jones JA, Schuh A, Devereux S, et al. (Ndira 2016). "Acalabrutinib powder (ACP-196) muRedapsed Chronic Lymphocytic Leukemia". Iyo New England Chinyorwa cheMishonga. 374 (4): 323-32.

[5] "Acalabrutinib powder Orphan Drug Kudomwa uye Kubvumidzwa". US Kudya neDrug Administration (FDA). Yakadzorerwa 15 Kubvumbi 2020.

[6] Walker I, Roland D (2015-12-17). "AstraZeneca yekutenga Stake muAcerta Pharma". Wall Street Journal. ISSN 0099-9660. Yakadzorerwa 2016-11-19.

[7] Hallek M Fischer K Munwe-Rowson G et al. Kuwedzera kwe rituximab kune fludarabine uye cyclophosphamide mune varwere vane chisingaperi lymphocytic leukemia: yakasarudzika, yakavhurika-label, chikamu 3 kutongwa. Lancet. 2010; 376: 1164-1174.

[8] Burger JA Tedeschi A Barr PM et al. Ibrutinib sekutanga kurapwa kwevarwere vane chisingaperi lymphocytic leukemia. N Engl J Med. 2015; 373: 2425-2437.