Afatinib (BIBW2992) - Mugadziri Wemuchina Wekutengesa
MUTSVENE unoburitsa Cannabidiol (CBD) upfu uye Hemp Yakakosha Oiri muhuwandu!

Afatinib (BIBW2992)

Rating: Category:

Afatinib powder, inotengeswa pasi pezita rekuti Gilotrif pakati pevamwe, mushonga unoshandiswa kurapa isiri-diki cell lung carcinoma (NSCLC). Iyo ndeya tyrosine kinase inhibitor mhuri yemishonga.Inotorwa nemuromo.

Product Description

Basic Hunhu

Product Name Afatinib upfu (BIBW2992)
CAS Number 850140-73-7
Molecular Formula C32H33ClFN5O11
Formula Weight 718.09
Synonyms 850140-73-7;

BIBW-2992;

BIBW 2992;

BIBW2992. Afatinib powder kuderera;

Kuonekwa Chiedza chine pfupa
Kuchengeta uye Kubata Kuoma, kusviba uye pa0 - 4 C kwenguva pfupi (mazuva kusvika kumavhiki) kana -20 C kwenguva refu (mwedzi kusvika makore).

 

Afatinib Powder Tsananguro

Afatinib powder, inotengeswa pasi pezita rekuti Gilotrif pakati pevamwe, mushonga unoshandiswa kurapa isiri-diki cell lung carcinoma (NSCLC). Iyo ndeya tyrosine kinase inhibitor mhuri yemishonga.Inotorwa nemuromo.Iyo inonyanya kushandiswa kurapa kesi dzeNSCLC dzinochengeta shanduko muepidermal kukura factor receptor (EGFR) gene.

Afatinib powder (BIBW2992), isingadzoreke inhibitor yemhuri yeErbB ye tyrosine kinases, yakaratidzwa kudzvinyirira EGF-inosimudzira phosphorylation yeEGFR uye kuwanda kwemasero mune akasiyana EGFR-overexpressing uye HER2-inoratidza maseru mitsara senge A431, NIH-3T3 -HER2, NCI-N87 uye BT-474.

Icho chinhu chakashandiswawo zvakanyanya mumhando dzakasiyana dzemhuka kuti dzidze basa reEGFR / HER2. Oral manejimendi yeafatinib poda yakavhara cancer cancer kukura uye kupona uye kudzvinyirira iyo bundu regression mune xenograft uye transgenic yemapapu mamodeli. Uye zvakare, afatinib poda inozivikanwa seEGFR blocker iyo yakabvumidzwa kurapwa kwevarwere vane EGFR-mutated nonsmall cell cancer cancer.

 

Afatinib Powder Maitiro Ekuita

Kunge lapatinib uye neratinib, afatinib poda ipuroteni kinase inhibitor iyo zvakare isingadzoreke inodzivirira epidermal kukura chinhu receptor 2 (Her2) uye epidermal yekukura factor receptor (EGFR) kinases.

Afatinib powder haingoshandisi chete pakurwisa shanduko yeEGFR yakanangwa nechizvarwa chekutanga tyrosine-kinase inhibitors (TKIs) senge erlotinib kana gefitinib, asiwo nekushanduka kushoma kunoenderana nemishonga iyi.

Nekudaro, haina kushanda kupokana neiyo T790M mutation iyo inowanzo inoda yechitatu chizvarwa zvinodhaka senge osimertinib. Nekuda kwechiitiko chayo chekuwedzera chinopesana naHer2, iri kuongororwa gomarara repazamu pamwe nemamwe magomarara eEGFR neHer2..

 

Afatinib Powder Kunyorera

Afatinib powder is anally bioavailable anilino-quinazoline derivative and inhibitor yeiyo receptor tyrosine kinase (RTK) epidermal grow factor receptor (ErbB; EGFR) mhuri, ine antineoplastic chiitiko.

Afatinib powder zvakare iri mumuromo bioavailable huviri receptor tyrosine kinase (RTK) inhibitor ine inogona antineoplastic chiitiko. EGFR / HER2 tyrosine kinase inhibitor BIBW 2992 isingadzokere shure inosunga nekudzivirira hutachiona hwevanhu hwekukura kwechinhu chinogamuchira 1 na2 (EGFR-1; HER2), izvo zvinogona kukonzeresa kukura kwethumba kukura uye angiogenesis. EGFR / HER2 maRTK ari emhuri yepamusoro yeEGFR; ese ari maviri anotamba makuru mabasa mune bundu sero kuwanda uye bundu vascularization uye vanowedzeredzwa zvakanyanya mumhando zhinji dzekenza maseru.

Afatinib powder inogamuchirwa munzvimbo zhinji dzenyika (kusanganisira United States, Canada, United Kingdom neAustralia) kuitira kurapwa kwemasastatic non-diki cell lung carcinoma (NSCLC), yakagadzirwa naBoehringer Ingelheim. Inoita seangiokinase inhibitor.

 

Afatinib Powder Side Mhedzisiro & Yambiro

Iyi inotevera mhedzisiro yakajairika (inoitika mune yakakura kupfuura 30%) yevarwere vanotora afatinib powder

▪ Manyoka

▪ Kuputika kweacneiform (boka remamiriro eganda akafanana neacne)

▪ Maronda emumuromo

▪ Paronychia (kubatwa nezvipikiri)

▪ Mukanwa makaoma

 

Aya mashoma mashoma mhedzisiro (anoitika mu10-29%) yevarwere vanogamuchira afatinib poda:

▪ Kuderedza kudya

▪ Kuvava

▪ Kuonda

▪ Mhuno inobuda ropa

▪ Cystitis (chirwere chedundira)

▪ Cheilitis (kuzvimba kwemiromo)

▪ Fivha

▪ Hypokalemia (yakaderera potasium)

▪ Conjunctivitis (ziso repingi)

▪ Rhinorrhea (kubuda mvura)

▪ Ma enzymes eropa akakwirira

Haasi ese mhedzisiro akanyorwa pamusoro. Zvimwe zvisingawanzoitika (zvinoitika mune isingasviki gumi muzana yevarwere) hazvina kunyorwa pano. Gara uchizivisa mupi wako wezvehutano kana iwe uchinge wawana chero zviratidzo zvisina kujairika.

 

Zvinhu zvakakosha zvekurangarira nezve iyo mhedzisiro yeafatinib poda:

▪ Vanhu vazhinji havazowani zvese afatinib powder mhedzisiro yakanyorwa.

▪ Afatinib poda mhedzisiro mhedzisiro inowanzo fungidzirwa maererano nekutanga kwavo, nguva, uye kuomarara.

▪ Afatinib upfu mhedzisiro mhedzisiro inowanzo kuve inodzoserwa uye inozopera mushure mekunge kurapwa kwapera.

▪ Afatinib powder mhedzisiro mhedzisiro inogona kunge ichikwanisika. Pane zvakawanda zvingasarudzwa zvekudzora kana kudzivirira mhedzisiro yeafatinib poda.

 

Reference

[1] Prim N, Fore M, Mennecier B. [Afatinib upfu (BIBW 2992).]. Rev Pneumol Clin. 2014 Chivabvu 27. pii: S0761-8417 (14) 00047-9. doi: 10.1016 / j.pneumo.2014.03.002. [Epub pamberi pokudhinda] Ongororo. ChiFrench. PubMed PMID: 24878189.

[2] D'Arcangelo M, Hirsch FR. Clinical uye yekufananidza utility yeafatinib poda mune isiri-diki kenza yemapapu kenza. Biologics. 2014 Kubvumbi 23; 8: 183-92. doi: 10.2147 / BTT.S40567. eCollection 2014. Ongorora. PubMed PMID: 24790411; PubMed Central PMCID: PMC4003149.

[3] Bowles DW, Weickhardt A, Jimeno A. Afatinib powder yekurapa kwevarwere vane EGFR-positive isina-diki kenza yemapapu kenza. Zvinodhaka Nhasi (Barc). 2013 Sep; 49 (9): 523-35. doi: 10.1358 / dot.2013.49.9.2016610. Ongorora. PubMed PMID: 24086949.

[4] Köhler J, Schuler M. Afatinib powder, erlotinib uye gefitinib muchikamu chekutanga chemushonga weEGFR mutation-positive lung adenocarcinoma: ongororo. Onkologie. 2013; 36 (9): 510-8. doi: 10.1159 / 000354627. Epub 2013 Aug 19. Ongororo. PubMed PMID: 24051929.

[5] Yap TA, Popat S. Basa reafatinib powder mukutarisira kweasina-madiki maseru mapapu carcinoma. Nyanzvi Opin Drug Metab Toxicol. 2013 Nov; 9 (11): 1529-39. doi: 10.1517 / 17425255.2013.832755. Epub 2013 Aug 28. Ongorora. PubMed PMID: 23985030.

[6] Dungo RT, Kubata GM. Afatinib powder: kutanga kugamuchirwa kwenyika. Zvinodhaka. 2013 Sep; 73 (13): 1503-15. doi: 10.1007 / s40265-013-0111-6. Ongorora. PubMed PMID: 23982599.

[7] Minkovsky N, Berezov A (Zvita 2008). "BIBW-2992, inonzi receptor receptor tyrosine kinase inhibitor yekurapa mamota akasimba". Pfungwa Dzazvino Mukutsvagisa Zvinodhaka. 9 (12): 1336-46. PMID 19037840

[8] Li D, Ambrogio L, Shimamura T, Kubo S, Takahashi M, Chirieac LR, et al. (Nyamavhuvhu 2008). "BIBW2992, isingachinjiki EGFR / HER2 inhibitor inoshanda zvakanyanya mumhando dzepenza dzemapapu". Oncogene. 27 (34): 4702–11. doi: 10.1038 / onc.2008.109. PMC 2748240. PMID 18408761.