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Alfaxalone

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Alfaxalone inonzi neuroactive steroid molecule ine zvinhu zveanesthetic yakajairika. Alfaxalone inotsanangurwa semakemikari se3-α-hydroxy-5-α-pregnane-11, 20-dione, uye ine uremu hwemaseru 332.5…

Product Description

Basic Hunhu

Product Name Alfaxalone
CAS Number 23930-19-0
Molecular Formula C21H32O3
Formula Weight 332.48
Synonyms Alphaxalone;

Alfaxalone;

23930-19-0;

5alpha-Pregnan-3alpha-ol-11,20-dione;

Alfaxalonum.

Kuonekwa White powder
Kuchengeta uye Kubata Chitoro pakamuri inodzorwa tembiricha -20 ° C

 

Alfaxalone Tsananguro

Alfaxalone inonzi neuroactive steroid molecule ine zvinhu zveanesthetic yakajairika. Alfaxalone inotsanangurwa semakemikari se3-α-hydroxy-5-α-nhumbu-11, 20-dione, uye ine mamorekuru uremu 332.5. Iyo yekutanga nzira yekuita kweanesthetic chiito chealfaxalone ndiko kuchinjika kweiyo neuronal cell membrane chloride ion yekufambisa, inokonzerwa nekusunga kwealfaxalone kuGABAA (gamma-aminobutyric acid) maseru epasireti receptors.

 

Alfaxalone Maitiro ekuita

Alfaxalone inogadzira kusaziva nekuita pane iyo gamma aminobutyric acid subtype A (GABAA) receptors mune yepakati tsinga system (CNS). Izvi zvinogamuchirwa ionotropic ligand-gated chiteshi, uye GABA ndiwo endo native ligand. GABA ndiyo inonyanya kudzivirira neurotransmitter muCNS. Mushure mokunge receptor yagadziriswa, mugero unovhura uye unosimudzira kloride conduction kupinda muchitokisi, zvichikonzera hyperpolarization yeiyo postynaptic membrane. Pakadzika kwakadzika, alfaxalone inonyatsogadzirisa chloride yazvino kuburikidza nekloride chiteshi; asi pakukwirisa kwepamusoro, inoshanda seGABA agonist, nenzira imwecheteyo nemabarbiturates. Mhedzisiro mhedzisiro yakadzika sedation kana induction yeanesthesia, zvinoenderana nedosi uye nzira yekutonga.

 

Alfaxalone Kushanda

Alfaxalone, inozivikanwawo se alphaxolone kana alphaxalone uye inoshandiswa pasi pezita rekutengeserana Alfaxan, iri neuroactive steroid uye yakajairika mushonga weanesthetic unoshandiswa muimbwa nekatsi. Inogona kushandiswa seyakagadziriswa induction kana yeiyo general anesthesia.

 

Alfaxalone Kubatsira & Kukanganisa

  • Advantages:

Alfaxalone inokonzeresa shanduko shoma mukubuda kwemoyo kana kuwedzerwa kweropa kana makiriniki akakodzera achiendeswa kune varwere vane hutano. Alfaxalone ine yakakwira yekurapa index, ipfupi inoshanda, uye isingaunganidzi. Aya maitiro anoita alfaxalone yakanakira kushandiswa seyakagadziriswa induction kana yekupa injekisheni anesthesia.

Alfaxalone inogona zvakare kupihwa intramuscularly, saka inogona kushandiswa kudzikamisa varwere vasina kubatana. Kana alfaxalone inoshandiswa kudzikamisa murwere muyero uri 1-3mg / kg IM uye inowanzo kupihwa pamwe neopioid yeakanakisa sedation.

Kana alfaxalone ichishandiswa muzvikamu zveKesariya iyo imbwa dzinenge dzakangwarira uye zvine hupenyu nekuvandudza zvikoro zveAGPAR zvichienzaniswa nepropofol.

 

  • payakaipira:

Alfaxalone inokonzeresa chirwere chinoenderana nekufema kushushikana, neapnea inogona kuitika zvichitevera kukurumidza IV jekiseni Gadzirira kugadzirira, kupa oxygen rutsigiro, uye kufefetera kana uchishandisa alfaxalone kune chero induction kana sedation.

Kuwedzeredza manejimendi yealfaxalone kunogona kukonzera dhizaini inoenderana nemoyo kushushikana, uye kwakadzikira kwakanyanya mune ese emoyo kuburitsa uye kuwedzerwa kweropa. Muyero wealfaxalone unofanirwa kunyatsotariswa mune varwere avo vakadzora masosi emoyo kana ari hemodynamically asina kugadzikana.

Alfaxalone haina kupa chero analgesia, saka inofanira kushandiswa pamwe chete neopioid yakakodzera kune zvinorwadza maitiro.

Kana alfaxalone ichiiswa mukati mekunetseka, huwandu hwejekiseni hunogona kukura, zvichikonzera marwadzo jekiseni. Iyo yakakura vhoriyamu inogona zvakare kuita manejimendi kuomesa kana paine yakaganhurirwa hwindo rejekiseni nekuda kweiyo murwere hunhu. Alfaxalone manejimendi inogona kukonzeresa murombo kupora kunoratidzwa neakasiyana madhigirii epaddling, vocalization, uye / kana myoclonus.

 

Reference

[1] Whittem T, Pasloske KS, Heit MV et al. (2008) Iyo pharmacokinetics uye pharmacodynamics yeAlfaxalone mumakati mushure mekusaroora uye kwakawanda kwetsinga kweAlfaxan pakiriniki uye supraclinical doses. J Vet Pharmacol Ther 31 (6), 571-579.

[2] Ferre PJ, Pasloske K, Whittem T et al. (2006) Plasma pharmacokinetics yealfaxalone muimbwa mushure meiyo intravenous bolus yeAlfaxan-CD. Vet Anaesth Analg 33, 229-236.

[3] Muir W, Lerche P, Wiese A et al. (2009) Iyo Cardiorespiratory uye anesthetic mhedzisiro yekiriniki uye supraclinical doses yealfaxalone mumakati. Vet Anaesth Analg 36, 42-54.

[4] Clarke KW, Trim CM, Horo LW, eds. (2014). "Chitsauko 15: Anesthesia yeiyo imbwa". Veterinary Anesthesia (11th ed.). Oxford: WB Saunders. mapeji 135-153.

[5] Varga M (2014). "Chitsauko 4: Anesthesia uye Analgesia". Chinyorwa cheRabbit Mushonga (2nd ed.). Butterworth-Heinemann. mapeji 178-202.

[6] Nieuwendijk H (Kurume 2011). "Alfaxalone". Veterinary Anesthesia & Analgesia Tsigiro Boka. Yakadzorerwa Chikunguru 14, 2017.

[7] Zeltzman P (Mbudzi 17, 2014). "Sei Kupa Alfaxalone Kunoda Chikamu Chedzidzo". Veterinary Dzidzira Nhau. Yakadzorerwa Chikunguru 14, 2017.