AZD-9291 powder (1421373-65-0) - Mugadziri Fekitori
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AZD-9291

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AZD-9291 poda iri epidermal yekukura factor receptor (EGFR) tyrosine kinase inhibitor (TKI) inosunga kune mamwe mutant mafomu eEGFR (T790M, L858R, uye exon 19 kubviswa) ayo anowanikwa mune isiri-diki cell cancer kenza (NSCLC) mamota. kutevera kurapwa neyekutanga-mutsetse EGFR-TKIs.

Product Description

Basic Hunhu

Product Name AZD-9291 upfu
CAS Number 1421373-65-0
Molecular Formula C28H33N7O2
Formula Weight 499.6
Synonyms 1421373-65-0;

osimertinib;

Mereletinib;

AZD9291;

N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide.

Kuonekwa Yakachena kusvika kune-white crystalline powder
Kuchengeta uye Kubata Chengetera pane tembiricha yemukati pakati pe20 ° C-25 ° C

 

AZD-9291 Powder Tsananguro

AZD-9291 powder inorapa yakanangwa iyo inotarisa iyo mutated epidermal kukura factor receptor (EGFR) T790M mukati mekenza kenza.

Iyo EGFR geni inoita basa rakakosha mune ese akajairwa uye maseru ekenza. Iri geni rinotungamira mukugadzirwa kweEGFR protein. Iyi protein inowanzo kuve chikamu checheni yemamorekuru ayo anotumira chiratidzo chinotaurira masero kukura nekukamurwa. Shanduko muEGGR gene (inonzi mutation) inogona kushandura mashandiro anoita EGFR protein. Panzvimbo pekumirira nguva yayo yekuratidzira sero kuti igovane kana kukura, iyo EGFR protein iri kunze kwekudzora uye inoratidza nguva dzese, izvi kunze kwekudzora EGFR zvichiratidza zvinogona kutungamira kukura kusingadzoreke kwecancer maseru. AZD-9291 upfu zvinangwa zvinosarudza mutant mafomu eEGFR, kusanganisira t790M, L858R uye exon 19-kubviswa. AZD-9291 poda inosarudzira kusimudzira shanduko uye iyo T790M yekumira kushanduka, inova ndiyo yakajairika mashandiro ekurwisa EGFR tyrosine kinase inhibitors.

 

AZD-9291 Powder Mashandiro Ekuita

AZD-9291 poda iri epidermal yekukura factor receptor (EGFR) tyrosine kinase inhibitor (TKI) inosunga kune mamwe mutant mafomu eEGFR (T790M, L858R, uye exon 19 kubviswa) ayo anowanikwa mune isiri-diki cell cancer kenza (NSCLC) mamota. kutevera kurapwa neyekutanga-mutsetse EGFR-TKIs. Sechizvarwa chechitatu-tyrosine kinase inhibitor, AZD-9291 powder yakanangana nemusuo-muchengeti T790M mutation inowedzera ATP inosunga chiitiko kuEGGR uye inoguma nehurombo hwekufungidzira kweanononoka-nhanho chirwere. Uyezve, AZD-9291 powder (osimertinib) yakaratidzirwa kuchengetedza yemhando-yemhando EGFR panguva yekurapwa, nokudaro ichideredza isiri-yakatarwa kusunga uye kudzikisira huturu.

 

AZD-9291 Powder Kunyorera

AZD-9291 powder mushonga unorapwa weiyo isiri-diki kenza yemapapu kenza (NSCLC) yakapararira kune zvimwe zvikamu zvemuviri (metastatic). AZD9291 inoshandiswa:

▪ Sekurapa kwako kwekutanga kana bundu riine imwe isina kujairika epidermal kukura factor receptor (EGFR) geni (s).

▪ Kana uine imwe mhando yeEGFR geni uye wakamborapwa nemushonga weEGFR tyrosine kinase inhibitor (TKI) wanga usingashande kana kuti usisashandi.

 

AZD-9291 Powder Side Mhedzisiro & Yambiro

AZD-9291 upfu zvinogona kukonzera zvakakomba mhedzisiro, kusanganisira:

▲ matambudziko emapapu. AZD-9291 powder inogona kukonzera matambudziko emapapu ayo anogona kutungamira kurufu. Zviratidzo zvinogona kunge zvakafanana nezviratidzo kubva pagomarara remapapu. Udza chiremba wako ipapo ipapo kana uine chero nyowani kana kuwedzera zviratidzo zvemapapu, kusanganisira kunetseka kufema, kufema kufema, kukosora, kana fivha.

Matambudziko emoyo, kusanganisira kutadza kwemoyo. AZD-9291 powder inogona kukonzera matambudziko emoyo anogona kutungamira kurufu. Chiremba wako anofanira kutarisa moyo wako musati watanga kutora AZD-9291 powder uye panguva yekurapa pazvinenge zvichidikanwa. Udza chiremba wako ipapo ipapo kana iwe uine chero anotevera zviratidzo nezviratidzo zvechinetso chemwoyo: kunzwa sekunge moyo wako uri kurova kana kumhanya, kufema kufema, kuzvimba kwemakumbo ako netsoka, uchinzwa musoro usina musoro.

▲ matambudziko eziso. AZD-9291 powder inogona kukonzera matambudziko emaziso. Udza chiremba wako ipapo kana iwe uine zviratidzo zvematambudziko eziso ayo anogona kusanganisira mvura inonaya, kunzwisisika kune mwenje, kurwadziwa kweziso, kutsvuka kweziso, kana shanduko yekuona. Chiremba wako anogona kukutuma kuti uone nyanzvi yeziso (ophthalmologist) kana iwe ukawana matambudziko eziso neAZD-9291 powder.

▲ matambudziko eganda. AZD-9291 powder inogona kukonzera matambudziko eganda. Udza chiremba wako ipapo kana iwe ukagadzira maronda maronda (maitiro eganda anotaridzika kunge zvindori), kupisa kwakanyanya kana kupenya kweganda

 

Mhedzisiro inowanzoitika ye AZD-9291 upfu vari:

▪ manyoka

▪ mapundu

▪ ganda rakaoma

▪ shanduko muzvipikiri zvako, zvinosanganisira: kutsvuka, unyoro, kurwadziwa, kuzvimba, brittleness, kupatsanurwa kubva kune nzara, uye kudururwa kwembambo

▪ maronda emuromo

▪ kuneta

▪ kuderedza kudya

Izvi hazvisi zvese zvinokanganisa mhedzisiro yeAZD-9291 poda. Kuti uwane rumwe ruzivo, bvunza chiremba wako kana wemishonga.

Dana chiremba wako kuti akupe mazano ekurapa nezvemigumisiro Unogona kuzivisa mhedzisiro kuDAA pa1-800-FDA-1088.

 

Reference

[1] Muchinjikwa DA, et al. AZD9291, isingachinjiki EGFR TKI, inokunda T790M-inomiririra kuramba kweEGFR inhibitors mukenza yemapapu. Kenza Discov. 2014 Sep; 4 (9): 1046-61.

[2] Finlay MR, et al. Kuwanikwa kweiyo ine simba uye inosarudza EGFR inhibitor (AZD9291) yeese ari maviri ekukurudzira uye ekumisidzana kweT790M inodzivirira iyo yemhando yemhando fomu yemubati. J Med Chem. 2014 Gumiguru 23; 57 (20): 8249-67.

[3] Hu X, Zhang ZY, et al. "Natural anthraquinone derivative shikonin inobatana neAZD9291 kurwisa wtEGFR NSCLC masero kuburikidza neakashanda oksijeni marudzi-anopindirana endoplasmic reticulum kushushikana." Phytomedicine. 2020; 68: 153189. PMID: 32070867

[4] Richtmann S, Wilkens D, et al. "FAM83A uye FAM83B sePrognostic Biomarkers uye Zvichida Zvitsva Zvokurapa Zvinangwa muNSCLC." Gomarara (Basel). 2019 Chivabvu 11; 11 (5). pii: E652. PMID: 31083571

[5] Cheriyan VT, Alsaab H, et al. "CARP-1 inoshanda mimetic komputa inobatana neBRAF-yakanangana nekenza isiri-diki yemukenza yemapapu." Oncotarget. 2018 Jul 3; 9 (51): 29680-29697. PMID: 30038713

[6] Darren Cross1, Sue Ashton1, Caroline Nebhan2 et al. AZD9291: isingachinjiki, ine simba uye inosarudza yechitatu chizvarwa tyrosine kinase inhibitor (TKI) yakanangana neEGFR inoshanda (EGFRm +) uye kuramba (T790M) shanduko mune yepamusoro mapapu adenocarcinoma. Mol Kenza Ther 2013; 12 (11 Suppl): A109.

[7] Liu YN,. Et al. Kuwana kuramba kweEGFR tyrosine kinase inhibitors inopindirana nekugadziriswa kwe STC2 / JUN / AXL kuratidza mukenza yemapapu, Int J Cancer, 2019, Jun 4 PMID: 31162839