Basic Hunhu

Product Name	Cabozantinib upfu
CAS Number	849217-68-1
Molecular Formula	C28H24FN3O5
Molar uremu	501.514
Synonyms	XL184, BMS907351; Cabometyx; Cometriq; Cabozanix.
Kuonekwa	White crystalline powder
Kuchengeta uye Kubata	Zvichengetedze pamhepo tembiricha uye kure nekupisa kwakanyanya uye hunyoro.

 

Cabozantinib Powdertsananguro

Cabozantinib Powder, inotengeswa pasi pezita rekuti Cometriq naCabometyx, mushonga unoshandiswa kurapa medullary cancer yegomarara, renal cell carcinoma, uye hepatocellular carcinoma. Iyo idiki mamorekuru inhibitor yeiyo tyrosine kinases c-Met uye VEGFR2, uye zvakare inodzivirira AXL neRET. Yakawanikwa uye kuvandudzwa neExelixis Inc.

MunaNovember 2012, cabozantinib powder (Cometriq) mune yayo capsule fomati yakatenderwa neUS Chikafu neDrug Administration (FDA) pasi pezita rekuti Cometriq yekurapa varwere vane medullary cancer yekenza. Iyo capsule fomu yakatenderwa muEuropean Union nechinangwa chimwe chete muna 2014.

Muna Kubvumbi 2016, iyo FDA yakapa mvumo yekushambadzira iyo piritsi yekuumba (Cabometyx) seyechipiri mutsara kurapwa kwekenza yeitsvo [8] [9] uye zvimwechetezvo zvakatenderwa muEuropean Union munaGunyana wegore iro. vane mafomati akasiyana uye haachinji.

 

Cabozantinib Powder Maitiro Ekuita

Cabozantinib Powder inodzivisa inotevera receptor tyrosine kinases: MET (hepatocyte grow factor receptor protein) uye VEGFR, RET, GAS6 receptor (AXL), KIT), uye Fms-senge tyrosine kinase-3 (FLT3).

 

Cabozantinib Powder kunyoresa

Cabozantinib powder inoshandiswa nenzira mbiri. Fomu kapsule rinoshandiswa kubvira 2012 kurapa medullary cancer yegomarara uye fomu rehwendefa rinoshandiswa kubvira 2016 seyechipiri mutsara wekurapa renal cell carcinoma.

 

Cabozantinib Powder Side Migumisiro & Yambiro

Cabozantinib powder haina kuongororwa mumadzimai ane pamuviri; inokonzera kukuvadza kune fetus mumakonzo. Vakadzi vane nhumbu havafanirwe kutora mushonga uyu, uye vakadzi havafanirwe kuve nepamuviri pavanenge vachinwa. Izvo hazvizivikanwe kana cabozantinib poda yakaburitswa mumukaka wemuzamu.Mushonga unofanirwa kushandiswa nekuchenjerera kune vanhu vane nhoroondo yematambudziko emoyo mutinhimira, kusanganisira yakareba QT nguva.

MuUS, iyo capsule formulation (Cometriq) inotakura nhema bhokisi inonyevera nezve njodzi yemakomba anoumba mudumbu kana ura pamwe nekuumbwa kwefistula (tunnel pakati peiyo GI turakiti uye ganda). Bhokisi dema rinoyambira zvakare pamusoro penjodzi yekubuda ropa kusingadzorwe. Kuumbwa kwehwendefa (Cabometyx) kunoyambira nezvezvinoitika izvi futi.

Iwo mavara anoyambira zvakare nezve njodzi yekugwamba kuumbika nekukonzera kurohwa kwemoyo kana kurohwa, BP, kusanganisira hypertensive dambudziko, osteonecrosis yeshaya, manyoka makukutu, ganda rinotsvedza kubva muzvanza nemakumbo, chirwere chine musoro, kuvhiringidzika, kurasikirwa kwemaonero , nekubatwa, uye mapuroteni anoonekwa mumuti

Mhedzisiro yakajairika zvakanyanya (yakakura kupfuura gumi muzana yevanhu) inosanganisira kuderera kwechido; yakaderera calcium, potasium, phosphate, uye magnesium mazinga; yakakwira bilirubin mazinga; pfungwa yakashata yekuravira, musoro, uye dzungu; BP; pfungwa yakashata yekunzwa, nzeve uye huro; manyoka, kuda kurutsa, kuzvimbirwa, kurutsa, kurwadziwa nemudumbu uye kushungurudzika mudumbu, uye kuzvimba kwemuromo nemiromo uye kunzwa kupisa mumuromo; ganda rinotsvedza kubva pamichindwe uye pasi petsoka, bvudzi vhudzi shanduko uye kurasikirwa nebvudzi, mapundu, ganda rakaoma, uye tsvuku ganda; kurwadza kwemajoini uye mhasuru spasms; kuneta uye kushaya simba; kuonda, kukwirisa transaminase, huwandu hwe cholesterol, uye kurasikirwa kwemasero matsvuku uye machena eropa.

 

Reference

[1] "Cabozantinib powder Shandisa Panguva Yepamuviri". Zvinodhaka.com. 30 Kurume 2020. Yakadzorerwa 23 Gunyana 2020.

[2] "Cabometyx- cabozantinib piritsi poda". Zuva Nezuva. 21 Chikunguru 2020. Yakadzorerwa 23 Gunyana 2020.

[3] "Cometriq- cabozantinib powder kit Cometriq- cabozantinib powder capsule". Zuva Nezuva. 11 Kukadzi 2020. Yakadzorerwa 23 Gunyana 2020.

[4] "Cometriq EPAR". European Medicines Agency (EMA). Yakadzorerwa 23 Gunyana 2020.

[5] "Cabometyx EPAR". European Medicines Agency. 17 Gunyana 2018. Yakadzorerwa 23 Gunyana 2020.

[6] "FDA inobvumidza Cometriq kurapa isingawanzo rudzi rwegomarara rekenza" (Press kuburitswa). US Kudya neDrug Administration (FDA). 29 Mbudzi 2012. Yakachengetedzwa kubva pane yekutanga Chikunguru 7, 2014.

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