Dacomitinib (1110813-31-4) poda - Mugadziri Fekitori Wemutengesi
MUTSVENE unoburitsa Cannabidiol (CBD) upfu uye Hemp Yakakosha Oiri muhuwandu!

Dacominib

Rating: Category:

Dacomitinib powder ndeye tyrosine kinase inhibitor. Kinase i enzyme inosimudzira kukura kwesero. Kune mhando zhinji dze kinases, dzinodzora nhanho dzakasiyana dzekukura kwemasero…

Product Description

Basic Hunhu

Product Name Dacomitinib upfu
CAS Number 1110813-31-4
Molecular Formula C24H25ClFN5O2
Formula Weight 469.9
Synonyms Dacomitinib upfu;

1110813-31-4;

PF299804;

Dacomitinib upfu (PF299804, PF299);

PF-00299804;

(2E)-N-(4-((3-chloro-4-fluorophenyl)Amino)-7-methoxyquinazolin-6-yl)-4-piperidin-1-ylbut-2-enamide.

Kuonekwa Muchena kana mhando yeupfu chena
Kuchengeta uye Kubata Chengetedza pakushambidzika kwemukati munzvimbo yakaoma.

 

Dacomitinib Powder Tsananguro

Dacomitinib powder ndeye tyrosine kinase inhibitor. Kinase i enzyme inosimudzira kukura kwesero. Kune akawanda marudzi e kinases, ayo anodzora akasiyana maseru ekukura kwesero. Mushonga uyu unonongedza Epidermal kukura factor receptor (EGFR) tyrosine kinase neexon 19 kubviswa kana exon 21 L858R kutsiva shanduko. Nekudzivirira EGFR, uyu mushonga unogona kudzora kukura kwemasero ekenza. Yako oncology timu ichaedza bundu rako nekuda kweichi chisina kujairika, chinofanirwa kunge chiripo kuti ugamuchire mushonga.

 

Dacomitinib Powder Maitiro Ekuita

Dacomitinib powder chinhu chisingachinjiki chidiki mamorekuru inhibitor yechiitiko chevanhu epidermal kukura factor receptor (EGFR) mhuri (EGFR / HER1, HER2, uye HER4) tyrosine kinases. Inoita isingadzoreki inhibition kuburikidza ne covalent bonding kune iyo cysteine ​​masara munzvimbo dzinobatsira dze HER receptors. Kushamwaridzana kwe dacomitinib powder kwakaratidzirwa kuve ne IC50 ye6 nmol / L.

Mhuri yeErbB kana epidermal yekukura chinhu (EGF) inoita chinzvimbo mukukura kwemota, metastasis, uye kurapwa kwekurapa nekumisikidza nzira dzekudzika dzerwizi dzakadai seRas-Raf-MAPK, PLCgamma-PKC-NFkB uye PI3K / AKT kuburikidza neiyo tyrosine kinase-inotyairwa phosphorylation ku carboxy-terminus. Makomba makumi mana muzana ezviitiko zvinoratidza kukwidziridzwa kweEGFR geni uye makumi mashanu muzana ezviitiko zviripo EGFRvIII mutation inomiririra kubviswa kunounza kuenderera kumisikidza kweiyo tyrosine kinase domain yeiyo receptor.

 

Dacomitinib Powder Kunyorera

Dacomitinib powder inoshandiswa kurapa imwe mhando yekenza yemapapu (isiri-diki kenza yemapapu kenza). Inoshanda nekuderedza kana kumisa kukura kwemasero ekenza.

Dacomitinib powder yakagamuchirwa kuti ishandiswe mune zvekurapa muUnited States munaGunyana 2018, muJapan mu2019, uye muEuropean Union mu2019, yekurapa isiri-diki kenza yemapapu kenza ine epidermal kukura factor receptor (EGFR) gene mutation.

 

Dacomitinib Powder Side Mhedzisiro & Yambiro

Kunyangwe zvingave zvisingawanzoitika, vamwe vanhu vanogona kunge vakaipa zvakanyanya uye dzimwe nguva vachiuraya mhedzisiro pavanotora mushonga. Udza chiremba wako kana kuwana rubatsiro rwechiremba ipapo kana iwe uine chero anotevera ezviratidzo kana zviratidzo zvinogona kunge zvine chekuita neakashata mhedzisiro mhedzisiro:

▪ Zviratidzo zvekusagadzikana, sekumhanyisa; mikoko; kuvava; tsvuku, kuzvimba, kubvaruka, kana kubvisa ganda rine kana risina kupisa; kurira; kuomarara mubhokisi kana pahuro; kunetseka kufema, kumedza, kana kutaura; hoarseness isina kujairika; kana kuzvimba kwemuromo, kumeso, miromo, rurimi kana huro.

▪ Zviratidzo zveshuga yakakwira muropa sekuvhiringidzika, kunzwa kurara, kuva nenyota, kunzwa nzara, kupfuudza weti kakawanda, kufuridza, kufema nekukurumidza, kana mweya unonhuwa kunge muchero.

▪ Zviratidzo zvezvinetso zve electrolyte sekuchinja kwemanzwiro, kuvhiringidzika, kurwadziwa kwemhasuru kana kushaya simba, kurova kwemoyo kusinganzwike, kubatwa, kusanzwa nzara, kana kurwadziwa zvakanyanya mudumbu kana kurutsa.

▪ Chero ganda rinogadziriswa.

▪ Kutsvuka kana kutsamwa kwezvanza zvemaoko kana tsoka dzetsoka.

▪ Kurwadziwa pachipfuva.

▪ Fivha.

▪ Zvakaipa uye dzimwe nguva zvinouraya mapapu matambudziko akaitika nedacomitinib powder. Fonera chiremba wako ipapo ipapo kana uine mapapu kana kufema matambudziko ari matsva kana akaipa sekukosora kana kufema kwekufema.

Izvi hazvisi zvese zvemhedzisiro zvinogona kuitika. Kana iwe uine mibvunzo nezve mhedzisiro, daidza chiremba wako. Dana chiremba wako kuti akupe mazano ekurapa nezvezvimwe zvikanganiso.

 

Reference

[1] Brzezniak C, Carter CA, Giaccone G: Dacomitinib powder, mushonga mutsva wekurapa kenza isiri-diki yemukenza yemapapu. Nyanzvi Opin Pharmacother. 2013 Kukadzi; 14 (2): 247-53. doi: 10.1517 / 14656566.2013.758714. Epub 2013 Ndira 7.

[2] Janne PA, Boss DS, Camidge DR, Britten CD, Engelman JA, Garon EB, Guo F, Wong S, Liang J, Letrent S, Millham R, Taylor I, Eckhardt SG, Schellens JH: Chikamu I dosi-kukwira kudzidza kwepan-HER inhibitor, PF299804, mune varwere vane huturu hwakasimba hwakasimba. Kliniki Kenza Res. 2011 Kurume 1; 17 (5): 1131-9. doi: 10.1158 / 1078-0432.CCR-10-1220. Epub 2011 Ndira 10.

[3] Smith M (6 Chikumi 2017). "Dacomitinib powder Inoisa PFS Rekodhi muChikamu chechitatu NSCLC Trial". MedPage Nhasi.

[4] Taylor P (28 Ndira 2014). "Furidzira kuPfizer sezvo dacomitinib poda ichikundikana mumiedzo yekenza yemapapu". pmlive.com.

[5] Sepulveda JM, Sanchez-Gomez P, Vaz Salgado MA, Gargini R, Balana C: Dacomitinib powder: mushonga wekuferefeta wekurapa glioblastoma. Nyanzvi Opin Investig Zvinodhaka. 2018 Oct; 27 (10): 823-829. doi: 10.1080 / 13543784.2018.1528225. Epub 2018 Gumiguru 5.

[6] Bethune G, Bethune D, Ridgway N, Xu Z: Epidermal grow factor receptor (EGFR) mukenza yemapapu: kuongorora uye kugadzirisa. J Thorac Dis. 2010 Mar; 2 (1): 48-51.

[7] Bethesda (2006). Zvinodhaka uye Lactation Dhatabhesi. National Raibhurari yeMishonga.

[8] Fry DW, Mabhiriji AJ, Denny WA, Doherty A, Greis KD, Hicks JL, Hook KE, Keller PR, Leopold WR, Loo JA, McNamara DJ, Nelson JM, Sherwood V, Smaill JB, Trumpp-Kallmeyer S, Dobrusin EM: Yakanangana, isingadzoreke kumisikidza kwepidermal kukura chinhu chinogamuchira uye erbB2, nekirasi nyowani ye tyrosine kinase inhibitor. Proc Natl Acad Sci US A. 1998 Sep 29; 95 (20): 12022-7.