Raw Dolastatin 10 (110417-88-4) HPLC≥98% | AASraw
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Dolastatin 10 (110417-88-4)

Rating: SKU: 110417-88-4. Category:

MUTSVENE unobatsira uye unyanzvi hwekugadzira kubva ku gram kusvika mukurongeka kweDolastatin 10 (CAS 110417-88-4), pasi peCGMP mutemo uye trackable quality control system.

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Product Description

 

Dolastatin 10 video

 

 


 

I.Dolastatin 10 basic Characters:

 

Name: Dolastatin 10
CAS: 110417-88-4
Molecular Formula: C42H68N6O6S
Molecular Kurema: 785.09g / mol
Melt Point: 94-95oC
Storage Temp: Chengetedza munzvimbo inotonhorera uye yakaoma uye pa0 - 4 ℃ yenguva pfupi (mazuva kusvika kumavhiki) kana -57 ℃ kwenguva yakareba (mwedzi kusvika makore)
Color: Yakachena kusvika pane-white sollid

 


 

II. Dolastatin 10 (110417-88-4) kushandiswa muhutano

 

1. Mazita:

Kemikari zita:
Dolastatin 10 (CAS 110417-88-4), Dolastatin-10, Neuro_000215, CCRIS 7310, CID100208, NSC376128,NSC 376128, C11280, L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-, (2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-

 

2.Dolastatin 10 Ushumiri:

Chinangwa: Nyanzvi yezvokurapa yakatsvaga kubudirira uye kuora kwezwi inoita anti-microtubule agent dolastatin-10 kune varwere vane kenza yepamusoro yepamu.

Nzira: Makumi makumi maviri nemana varwere vane kenza inogona kuenzaniswa yekaseti yemasasa yakarapwa ne dolastatin-10 pachirwere che 400 mcg / m2 neine muchengeti wepirus kamwe mushure mavhiki e3.

Migumisiro: Mumwe kubva kune vane 21 (5%; 95% CI: 0-24%) akawana kuregererwa kwekanguva kwemazuva e113. Varwere vana vakachengetedza zvirwere zvakagadzikana zvemazuva mashoma e87. Varwere vakagamuchira miviri miviri ye dolastatin-10. Hematologic toxicity yakanga yakaenzanisa, nevarwere ve8 varikugadzira grade 4 neutropenia, uye 5 neklasi 3 neutropenia; rimwe kirasi 3 febrile neutropenia yakaonekwa. Izvi zvikamu zvegadziriro 3 uye 4 neutropenia zvakagadzirirwa pa 36% yemishonga yekurapa. Non-hematologic toxicity yakanga isingawanzoitiki.

Mhedziso: Kunyange zvazvo chinyorwa chetsvina che dolastatin-10 chakanga chichigamuchirwa, chakanga chine basa shoma mukudzidza kwekenza yepamusoro ino.

In Vitro: Dolastatin 10 inokosha yepentapeptide iyo yakatarwa kubva kugungwa muDolala kuricularia. Inowanikwa kuti idzi in vitro data dzakangofanana neyaDolastatin 10 neArgistatin PE, imwe neimwe iyo ine GI50 inokosha ye 10-5-10-6 μg / mL (10-2-10-3 nM) nechinangwa chakafanana minipanel of human cell lines. The antibody-drug conjugate (ADC) inosanganisira anti-CD30 monoclonal antibody cAC10 inogadziriswa ku cytotoxic mujeri monomethyl auristatin E (MMAE), analog inogadzirwa ye tubulin polymerization inhibitor Dolastatin 10 (110417-88-4).

 

3.Zvava pane Dolastatin 10

Ichi chigadzirwa ndechokutsvakurudza kushandiswa chete, kwete kwevanhu kana zvekushandiswa kwemhuka.

Kuti uwane kuvhara kwepamusoro, tapota furai tube mu 37 ℃ uye muizunungure muwaini ye ultrasonic kwekanguva.Solution solution inogona kuchengetwa pasi -20 ℃ kwemwedzi inoverengeka.

 

4.kuwedzera mirayiridzo:

Dolastatin 10 synthesis
Zvose zvakaitwa neDolastatin 10 (110417-88-4) yakapedzwa nekuvandudza kushandiswa kwakanaka kwezvinhu zviviri zvinokosha ma-amino acid components, Dil (6) uye Dap (11), uye kuwirirana kwechikamu chechikamu chechikamu chemaamino acid kubva kuC-terminal Doe .

Synthesis uye Kuongorora kweDotlastatin 10 Analogues Inosanganisira Heteroatoms paAmino Acid Side Chains.
Shanduro dzakasiyana-siyana dzekuzvarwa dzinoita dolastatin 10 dzinofarira zvikuru kenza nekuda kwezvakawanda zvebasa ravo rekuita uye kushandiswa kwadzo sekubhadhara mu anti anti-drug conjugates (ADCs). Kugadziriswa kwe dolastatin 10 core scaffold yakanyanya kunyanya kugadziriswa kweP1, N-terminus, neP5, C-terminus, isina kunyanya kutarisa pasi peP2.

Muchiedza chemashure, Dolastatin 10 (110417-88-4) inoratidzira basa kune rimwe ropa revanhu, lymphoma uye yakasimba tumor cell lines (yakadai seOVCAR-3 neNSCLC) neIncxNUMX mitemo kubva 50nM kusvika 0.1nM. Iko zvino yakaedzwa mumakiriniki.

 


 

III. Dolastatin 10 (110417-88-4) HCML

Tiri Aprepitant powder supplie, Aprepitant powder inotengeswa, Raw Aprepitant powder (170729-80-3) hplc≥98% | AASraw R & D Reagents

 


 

IV. How kutenga Dolastatin 10 kubva AASraw?

 

1.Kutaurirana nesu ne email yedu yekubvunza system, kana online skypeMutariri wevashandi (CSR).
2.Kutipa isu yakabvunzwa nekero.
3.Our CSR ichakupa iyo quotation, nguva yekubhadhara, nhamba yekutsvaga, nzira yekuendesa uye inofungidzirwa zuva rekuuya (ETA).
4.Payment yakaitwa uye zvigadzirwa zvichaendeswa mumaawa e12 (Kurongeka mukati me10kg).
5.Goods inogamuchira uye inopa mhinduro.