Gefitinib powder (184475-35-2) - Mugadziri Fekitori Mutengesi
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Gefitinib

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Gefitinib upfu imhando yemushonga uyo waishandiswa kurapa isiri-diki kenza yemapapu kenza yakapararira kune dzimwe nhengo dzemuviri uye isati yatobatwa neimwe mishonga yekurapa cancer.

Product Description

Basic Hunhu

Product Name Gefitinib upfu
CAS Number 184475-35-2
Molecular Formula C22H24ClFN4O3
Formula Weight 446.9
Synonyms Gefitinib upfu (184475-35-2);

ZD1839;

Gefitinib upfu Iressa;

N-(3-Chlor-4-fluorophenyl)-7-[methoxy-6-[(3-morpholin-4-yl)propoxyl]-quinazolin-4-yl]amine.

Kuonekwa White powder
Kuchengeta uye Kubata Chengetera panodzorwa tembiricha yemukamuri 20 ° C-25 ° C.

 

Gefitinib Powder Tsananguro

Gefitinib Powder imhando yemushonga uyo waishandiswa kurapa isiri-diki kenza yemapapu kenza yakapararira kune dzimwe nhengo dzemuviri uye isati yatobatwa neimwe anticancer kurapwa. Inoshandiswa kune varwere vane kenza ine zvimwe zvinoshanduka (shanduko) mune geni inonzi epidermal kukura factor receptor (EGFR). Iri zvakare kudzidziswa mukurapa kwemamwe marudzi ekenza. Gefitinib powder inovhara mamwe mapuroteni akagadzirwa neye mutated EGFR gene, iyo inogona kubatsira kuchengetedza maseru emukenza kubva mukukura. Izvo zvinogona zvakare kudzivirira kukura kwemidzi mitsva yeropa iyo mamota anoda kukura. Gefitinib powder rudzi rwe tyrosine kinase inhibitor uye rudzi rweantiangiogenesis mumiririri. Inonziwo Iressa uye ZD1839.

 

Gefitinib Powder Maitiro Ekuita

Targeted Therapis ndeye mhedzisiro yemakore zana ekutsvagira yakatsaurirwa kunzwisa mutsauko uripakati pemasero ekenza nemasero akajairwa. Parizvino, kurapwa kwegomarara kwakanangana nekuuraya nekukurumidza kunokamura masero nekuti chimwe chikamu checancer maseru ndechekuti dzinopatsanuka nekukurumidza. Nehurombo, mamwe emasero edu akajairika anopatsanuka nekukasira zvekare, zvichikonzeresa mhedzisiro.

Targeted Therapic ndeyekutsvaga mamwe maficha ekenza maseru. Masayendisiti anotarisa misiyano yakatarwa mumasero ekenza uye nemasero akajairwa. Ruzivo urwu runoshandiswa kugadzira chakanangwa kurapwa kurwisa gomarara maseru pasina kukuvadza zvakajairika maseru, nokudaro zvichitungamira kune mashoma emhedzisiro. Mhando yega yega yekurapa kwakanangwa inoshanda zvishoma zvishoma asi zvese zvinokanganisa kugona kwesero rekenza kukura, kupatsanura, kugadzirisa uye / kana kutaurirana nemamwe maseru.

Kune akasiyana marudzi eanotarisirwa marapirwo, anotsanangurwa muzvikamu zvitatu zvakafara. Zvimwe zvakanangwa zvekurapa zvinotarisa pazvinhu zvemukati uye mashandiro ekenza kenza. Marapirwo akanangwa anoshandisa mamorekuru madiki anogona kupinda musero uye kukanganisa mashandiro emaseru, zvichikonzera kufa kwavo. Kune akati wandei marudzi eakanangwa kurapa anotarisa mukati memukati memasero. Zvimwe zvakanangwa zvekurapa zvinonanga zvinogamuchirwa zviri kunze kwesero. Therapies iyo inotarisa receptors inozivikanwa zvakare se monoclonal antibodies. Antiangiogenesis inhibitors inotarisa tsinga dzeropa dzinopa okisijeni kumasero, zvichizopedzisira zvichikonzera maseru kufa nenzara.

Genefitinib chirwere chakanangwa chinotarisa uye chinosunga kune iyo epidermal yekukura factor receptors (EGFR) pamusoro pechitokisi. EGFR inowanikwa pamusoro pemazhinji masero akajairwa uye gomarara. Nekusunga kune izvi zvinogamuchirwa genefitinib inovhara nzira yakakosha inosimudzira kupatsanurwa kwesero. EGFR inowanzo kuratidzwa kuve yakanyanya kufungidzirwa mune mamwe maseru evanhu ecarcinoma, senge mapapu uye kenza yemazamu maseru. Kunyanyisa kuwedzera kunotungamira mukusimudzira mashandisiro eanopokana-apoptotic Ras chiratidzo kutapudza macascades, zvichizoguma nekuwedzera kupona kwemaseru ekenza uye kusadzora kuwanda kwesero. Gefitinib powder ndiyo yekutanga inosarudza inhibitor yeEGFR tyrosine kinase iyo inonziwo Her1 kana ErbB-1. Nekudzivirira EGFR tyrosine kinase, iyo yekudzika yekuisa chiratidzo macascades zvakare akaremerwa, zvichikonzera kudzivirirwa kwakaipisisa kwemasero kuwanda.

Kutsvakurudza kunoramba kuchicherechedza kuti zvipi zvekenza zvinogona kurapwa zvakanakisisa nemishonga inotarisirwa uye kuziva zvimwe zvinangwa zvemamwe marudzi ekenza.

Cherechedza:  Tinokukurudzira zvikuru kuti utaure nachiremba wako nezvehutano hwako uye marapirwo. Ruzivo rwuri mune ino webhusaiti rwakagadzirirwa kubatsira uye kudzidzisa, asi harwitsire zano rekurapa.

 

Gefitinib Powder Chikumbiro

Gefitinib powder inoshandiswa kurapa vamwe vanhu vane kenza isiri-diki yemapapu yemapapu (NSCLC).

Mushonga uyu unongoshanda chete kumatare eNSCLC ane shanduko dzinodaidzwa kuti EGFR shanduko pamusoro pemasero avo. EGFR shanduko dzinowanzoitika muNSCLC mu:

♦ vakadzi

Who vanhu vasina kumbosvira

♦ vanhu vane adenocarcinoma (imwe mhando yeNSCLC)

♦ vanhu vedzinza reAsia

Pane bvunzo dzekutarisa padanho reEGFR. Iyi bvunzo ichakubatsira iwe navanachiremba kusarudza kana muchizogona kubatsirwa nekurapwa ne gefitinib powder. Iyi bvunzo inogona kuitwa panguva imwechete sekuongororwa kana inogona kuitwa pachishandiswa masampuli ekenza maseru kubva kune apfuura biopsies kana kuvhiyiwa.

 

Gefitinib Powder Side Mhedzisiro & Yambiro

Hatina kunyora zvese mhedzisiro. Hazviwanzoita kuti iwe uve nezvose izvi zvinokanganisa, asi iwe unogona kunge uine mamwe acho panguva imwe chete.

Inguvai uye sei yakakomba mhedzisiro yacho inogona kusiyana kubva pamunhu kuenda kumunhu. Izvo zvinoenderanawo nekumwe kurapwa kwauri kuita. Semuenzaniso, yako mhedzisiro mhedzisiro inogona kuve yakaipa kana iwe uri zvakare kuva nemimwe mishonga kana radiotherapy.

 

Zvinowanzovhiringidza

▪ Ganda rinochinja

▪ Manyoka

▪ Kunzwa kana kurwara

▪ Rwadza muromo nemaronda

▪ Kutadza kudya

▪ Chiropa chinochinja

▪ Kushaya simba uye simba

 

Dzimwe nguva mhedzisiro

Imwe yeiyi mhedzisiro inoitika mune inopfuura 1 muvanhu zana (100%). Unogona kunge uine imwe kana dzakawanda dzadzo. Zvinosanganisira:

▪ Njodzi inowedzera yekubuda ropa senge mumhino kubuda ropa kana ropa mune weti

▪ Nzara dzakaoma, dzinopwanyika kana dzakasununguka panguva yekurapwa

▪ Kuzvimba kwedundira kunokonzera kurwadziwa kana uchipfuudza weti uye unoda kupfuudza weti kazhinji

▪ Zvinetso zvepvo izvo zvisingawanzo kukonzera chero zviratidzo

▪ Kupisa kwakanyanya - fivha

▪ Matambudziko eziso akadai sekutsvuka, kuvaviwa, kuoma maziso kana kuona kwakadzima

▪ Anorwadza, maziso matsvuku kana eyelashes

▪ Kuonda kwebvudzi rako

▪ Zvinetso zvemapapu

▪ Hauna mvura yakakwana mumuviri (kupera mvura mumuviri) inokonzerwa nemanyoka, kurwara kana kupererwa nehavi

▪ Kurwara kumwe kunokonzera kukosora, kumhanyisa kana kuzvimba udza chiremba wako kana izvi zvikaitika

 

Kazhinji migumisiro yakaipa

Imwe yeiyi mhedzisiro inoitika mune mashoma pane mumwe muvanhu zana (1%). Unogona kunge uine imwe kana dzakawanda dzadzo. Zvinosanganisira:

▪ Kuzvimba kwerwatata

▪ Buri mudumbu kana ura

▪ Kuzvimba kwechiropa

▪ Zvinetso zvemaziso

 

Reference

[1] Sordella R, Bell DW, Haber DA, Settleman J: Gefitinib-inosimudzira EGFR shanduko mukenza yemapapu inogadzira anti-apoptotic nzira. Sayenzi. 2004 Aug 20; 305 (5687): 1163-7. Epub 2004 Jul 29.

[2] Moasser MM, Basso A, Averbuch SD, Rosen N: Iyo tyrosine kinase inhibitor ZD1839 ("Iressa") inotadzisa chiratidzo chinotungamirwa neHER2 uye inodzvinyirira kukura kweHER2-overexpressing tumarara maseru. Cancer Res. 2001 Gumiguru 1; 61 (19): 7184-8.

[3] Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nyukiliya Acids Res. 2002 Jan 1; 30 (1): 412-5.

[4] Nicholson RI, Hutcheson IR, Harper ME, Knowlden JM, Barrow D, McClelland RA, Jones HE, Wakeling AE, Gee JM: Modulation yeepidermal kukura factor receptor mune endocrine-inodzivirira, estrogen receptor-inovhenekera kenza yemazamu Endocr Relat Kenza. 2001 Sep; 8 (3): 175-82.

[5] Suzumura T, Kimura T, Kudoh S, Umekawa K, Nagata M, Matsuura K, Tanaka H, ​​Mitsuoka S, Yoshimura N, Kira Y, Nakai T, Hirata K. varwere vane isiri-diki kenza yemapapu kenza. Gomarara reBMC. 2 Zvita 6; 2012: 4. doi: 12 / 568-10.1186-1471-2407.

[6] Shi Z, Parmar S, Peng XX, Shen T, Robey RW, Bates SE, Fu LW, Shao Y, Chen YM, Zang F, Chen ZS: Iyo epidermal yekukura chinhu tyrosine kinase inhibitor AG1478 uye erlotinib inodzosera ABCG2-inopindirana. kusagadzikana kwemishonga. Oncol Mumiriri. 2009 Feb; 21 (2): 483-9.

[7] An Y, Ongkeko WM: ABCG2: kiyi chemoresistance mukenza maseru maseru? Nyanzvi Opin Drug Metab Toxicol. 2009 Zvita; 5 (12): 1529-42. doi: 10.1517 / 17425250903228834.

[8] Rossi S, mupepeti. Australian Medicines Handbook 2004. Adelaide: Australian Medicines Handbook; 2004.