Ibrutinib powder (936563-96-1) - Mugadziri Fekitori Wemagetsi
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Ibrutinib

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Ibrutinib powder inovhara protein inonzi Bruton's tyrosine kinase (BTK), iyo inogona kubatsira kuchengetedza maseru emukenza kubva mukukura. Iyo mhando ye tyrosine kinase inhibitor. Iyo inonziwo Imbruvica.

Product Description

Basic Hunhu

Product Name Ibrutinib upfu
CAS Number 936563-96-1
Molecular Formula C25H24N6O2
Formula Weight 440.5
Synonyms IBRUTINIB upfu (PCI-32765);

(R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo-[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-;PCI-32765 (Ibrutinib powder);

1[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1Hpyrazolo [3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one).

Kuonekwa Yakachena kune off-chena poda
Kuchengeta uye Kubata Chengetera mune yekutanga, yakanyorwa mudziyo mukamuri tembiricha uye munzvimbo yakaoma.

 

Ibrutinib Powder Tsananguro

Ibrutinib powder rudzi rwemushonga uyo waishandiswa wega kana nemamwe madhiragi ekurapa vanhu vakuru vane chisingaperi lymphocytic leukemia, diki lymphocytic lymphoma, kana Waldenstrom macroglobulinemiaemia (rudzi rweiyo isiri Hodgkin lymphoma). Inoshandiswawo chete kurapa vanhu vakuru vane mantle cell lymphoma kana marginal zone lymphoma avo vakagamuchira imwe chete kurapwa. Iri zvakare kudzidziswa mukurapa kwemamwe marudzi ekenza. Ibrutinib powder inovhara puroteni inonzi Bruton's tyrosine kinase (BTK), iyo inogona kubatsira kuchengetedza maseru ekenza kubva mukukura. Iyo mhando ye tyrosine kinase inhibitor. Iyo inonziwo Imbruvica.

 

Ibrutinib Powder Maitiro Ekuita

Ibrutinib powder ine simba uye isingachinjiki inhibitor yeBruton's tyrosine kinase (BTK), chinhu chakakosha cheB-cell receptor (BCR) uye cytokine receptor nzira. Kugadziriswa kweB-cell receptor signaling kwakakosha kuti kupona kweanoshatisa B-maseru; BTK inhibition inoguma nekuderera kwakashata B-cell kuwanda uye kupona.

 

Ibrutinib Powder Chikumbiro

Ibrutinib powder inogamuchirwa muEurope yekurapa matatu marudzi e lymphoma.

 

Antle Pfeka cell lymphoma

Kune vanhu vane lymphoma vakadzokera (vadzoka) kana vasina kupindura kurapwa (refractory lymphoma). Ibrutinib powder inopihwa yega.

 

♦ Isingaperi lymphocytic leukemia (CLL)

Kune vanhu vasati vamborapwa CLL yavo (yekutanga-kurapwa kurapwa). Ibrutinib powder inogona kupihwa yega kana musanganiswa neRituximab kana obinutuzumab (antibody Therapies). Kune vanhu vane CLL vakadzokera shure mushure mekurapwa. Kune vanhu vakadzokerazve CLL, ibrutinib powder inogona kupihwa yega kana ne bendamustine (chemotherapy drug) uye rituximab.

 

Mac Waldenström's macroglobulinaemia (WM)

Kune vanhu vakambowana mamwe marapirwo eWM. Kune vanhu vasingakwanise kuve ne chemo-immunotherapy (chemotherapy ine antibody therapy) sekutanga-mutsara kurapwa.

Kubvumidzwa kweEuropean kushandisa ibrutinib poda muCLL uye mantle cell lymphoma yakapihwa munaNovember 2014. Yakabva yaendeswa kune WM muna Chivabvu 2015. Muna 2016, iyo European Medicines Agency (EMA) yakawedzera ibrutinib powder inokurudzirwa mashandisiro eCLL.

Ibrutinib powder iri kuedzwa mune mamwe makiriniki ekuedzwa mune vanhu vane aya marudzi e lymphoma. Izvi ndezve kuona kana ibrutinib poda inogona kushanda zvirinani pamwe chete nemamwe marapirwo, senge chemotherapy kana antibody therapy (semuenzaniso, rituximab) Iri zvakare kuedzwa mune mamwe marudzi e lymphoma. Shandisa dhatabhesi yedu yekutsvaga kuti uone kana paine kiriniki yekuyedzwa iyo inogona kunge yakakukodzera iwe kuLymphoma TrialsLink.

 

Ibrutinib Powder Side Mhedzisiro & Yambiro

Tsvaga rubatsiro rwezvehutano rwekukurumidzira kana iwe une zviratidzo zvehutano hunoita: mikoko; kufema kwakaoma; kurira kwechiso chako, miromo, rurimi, kana huro.

Rega kushandisa ibrutinib powder uye dana chiremba wako kamwechete kana iwe uine:

▪ zviratidzo zvehutachiona - fivhiri, kutonhora, kushaya simba, maronda emumuromo, kukosora nemamousu, kunetseka kufema;

▪ zviratidzo zvekubuda ropa mukati memuviri wako - dzungu, kushaya simba, kuvhiringidzika, matambudziko nekutaura, kutemwa nemusoro kwenguva refu, zvitema kana ropa rine tsvina, weti yepingi kana shava, kana kukosora ropa kana kurutsa zvinoita kunge nzvimbo yekofi;

▪ manyoka akasimba kana anoramba aripo;

▪ kurwadziwa pachipfuva, kurova kwehana kana kurova chipfuva, uchinzwa senge ungangopfuura.

▪ kutemwa nemusoro zvakanyanya, kusaona zvakanaka, kurova muhuro kana nzeve dzako;

▪ kukuvara kuri nyore, kubuda ropa zvisina kujairika, ruvara rwepepuru kana tsvuku pasi peganda rako

▪ ganda rakachenuruka, maoko nemakumbo zvinotonhora;

▪ matambudziko eitsvo - kuita weti shoma kana kusatomboita, kuzvimba mutsoka kana mumakumbo; kana

▪ zviratidzo zvekutsemuka kwemaseru-kuvhiringidzika, kushaya simba, kushushikana kwemhasuru, kusvotwa, kurutsa, kukurumidza kana kunonoka kurova kwemoyo, kuderera kwekuita weti, kurira mumawoko ako nemakumbo kana pamuromo wako.

 

Misungo yakajairika inogona kusanganisira:

▪ manyoka, kuda kurutsa;

▪ fivha, kukosora, kunetseka kufema;

▪ mapundu kana maronda mumuromo mako;

▪ kunzwa kuneta;

▪ kukuvara, mapundu; kana

▪ kurwadziwa nemhasuru, kurwadziwa nemabhonzo.

 

Iri haisi rondedzero yakazara yemigumisiro uye vamwe vanogona kuitika. Dana chiremba wako kune mazano ekurapa nezvemigumisiro. Iwe unogona kuudza migumisiro yakaipa kune FDA pane 1-800-FDA-1088.

 

Reference

[1] Ahn IE, Jerussi T, Farooqui M, Tian X, Wiestner A, Gea-Banacloche J. Atypical Pneumocystis jirovecii pneumonia mune vaimbove vasina kurapwa varwere vane CLL pane imwechete-mumiririri ibrutinib powder. Ropa. 2016; 128 (15): 1940-1943. [PubMed 27503501].

[2] Wang ML, Mutemo S, Martin P, et al. Targeting BTK ine ibrutinib poda mune yakadzokazve kana kusagadzikana mantle-cell lymphoma. N Engl J Med, 2013; 369 (6): 507-516. [PubMed 23782157].

[3] Byrd JC, Furman RR, Coutre SE, uye al. Targeting BTK ine ibrutinib powder mune yakadzokazve isingagumi lymphocytic leukemia. N Engl J Med. 2013; 369 (1): 32-42. [PubMed 23782158].

[4] Kamel S, Horton L, Ysebaert L, et al. Ibrutinib powder inhibits collagen-mediated asi kwete ADP-inogadziriswa platelet aggregation. Leukemia. 2015; 29 (4): 783-787. [PubMed 25138588].

[5] Marostica E, Sukbuntherng J, Loury D, uye al. Population pharmacokinetic modhi yeibrutinib powder, Bruton tyrosine kinase inhibitor, mune varwere vane B cell malignancies. Kenza Chemother Pharmacol. 2015; 75 (1): 111-121. [PubMed 25381051].

[6] Salem JE, Manouchehri A, Bretagne M, et al. Cardiovascular toxicities inosanganiswa neibrutinib powder. J Ndiri Coll Cardiol. 2019; 74: 1667-1678. doi: 10.1016 / j.jacc.2019.07.056. [PubMed 31558250].

[7] Imbruvica (ibrutinib powder) [kurondedzera ruzivo]. Sunnyvale, CA: Pharmacyclics; Kubvumbi 2020 ..

[8] Treon SP, Tripsas CK, Meid K et al. Ibrutinib powder mune yakamborapwa Waldenström's macroglobulinemia. N Engl J Med. 2015; 372 (15): 1430-1440. [PubMed 25853747].