IDFP

ICHINYANYA ndechekugadzirisa uye kugadzira zvigadzirwa kubva ku gram kusvika mukuraira kweDFFP (615250-02-7), pasi peCGMP mutemo uye trackable quality control system.

IDFP inhengo yegopophosphorus iyo inoderedza MAGL ne FAAH ne IC50 tsika dze 0.8 uye 3 nM, zvichienderana.1 Pa 10 mg / kg, IDFP inosimudzira hutano hweHNUMX-AG neAEA kupfuura 2, uye inoderedza mazinga e arachidonic acid zvakafanana zvakakura. I-endocannabinoids, 10-arachidonoyl glycerol (2-AG) uye arachidonoyl ethanolamide (AEA), vane biologically vanobata lipids dzinodzora zvakasiyana-siyana zvehutano nehutachiona nekugadzirisa zvinokonzerwa neinnabinoid, central cannabinoid (CB2) uye pecharal cannabinoid (CB1). Monoacylglycerol lipase (MAGL) uye fatty acid amidehydrolase (FAAH) hydrolyze 2-AG neAEA, maererano nokudaro, vachigumisa basa ravo rezvisikwa.

Product Description

IDFP video


I.IDFP Basic Characters:

Name: IDFP
CAS: 615250-02-7
Molecular Formula: C15H32FO2P
Molecular Weight: 294.391
Melt Point:
Storage Temp: -20 ° C
Color:


II. IDFP kufamba

1.Names:

Makemikari Mazita: ISOPROPYL DODECYLFLUOROPHOSPHONATE
Synonym:
IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE; P-DODECYL-1-METHYLETHYL ESTER-PHOSPHONOFLUORIDIC ACID

2. IDFP Kushandisa:

IDFP inhengo yegopophosphorus inobatanidza nhengo yehuti sarin. Kungofanana nesarin, IDFP inhibitor isingagadziriswi yemhando dzakasiyana-siyana dzakasiyana-siyana dzinowanzobatsira kuputsa maurotransmitter, asi iyo yakakura yeakine chain ye IDFP inoita kuti iite simba zvakanyanya seinhibitor of acetylcholinesterase (AChE), ine IC50 ye6300nM chete, iyo inhibitor yakasimba yemadziviri enzyme monoacylglycerol lipase (MAGL), iyo enzyme yekutanga inoshandiswa kukanganisa endocannabinoid 2-arachidonoylglycerol (2-AG), uye mafuta asidi amide hydrolase (FAAH), iyo enzyme yekutanga inoshatisa imwe yakanyanya endocannabinoid anandamide . IIC50 ye IDFP i0.8nM pa MAGL, uye 3.0nM ku FAAH. Kuvharidzira maviri enzymes kunokonzera kuwedzera kwemazinga maviri anandamide uye 2-AG muuropi, zvichiita kuti isnabinoid zviratidzo zvisingagoni kuitika uye zvinowanzoita zvinokonzerwa nehutabhaid inogadziriswa muzvidzidzo zvemhuka, nepo kushaya simba kweChhE kunoreva kuti hapana zviratidzo zvechilinergic zvinogadzirwa. [1 ] [2] [3] [4] Pasinei nemakemikari akafanana akadaro kune maitiro emarambidzwa akavharidzirwa, iyo yakakura yeakisikiti yechina yeDFFP inokonzera kuti irege kunze kwetsanangudzo ye "chemishonga inokonzera" pasi peChristal Weapons Convention, [5] uye kubvira iyo hainawo kuratidza simba rakanyanya AChE rinopesana nedzimwe sangano re organophosphorus, IDFP haisi pasi pemitemo yakadaro yepamutemo yepamutemo.

3.Chii chiyero cheDFFP?

Kwekugara kwenguva refu, tinopa kuti IDFP ichengetwe sezvinowanikwa pa -20 ℃. Inofanira kuva yakasimba kune gore rimwechete.
IDFP inopiwa semhinduro mu methyl acetate. Kuti uchinje gadziriro yacho, ingobuda mhepo ye methyl acetate pasi pemvura yakanyorova ye nitrogenand nokukurumidza kuwedzera yekusarudzwa kwesarudzo.Solvents yakaita ethanol, DMSO, uye dimethyl formamide yakanatswa negesi inert inogona kushandiswa. Iko kushandiswa kweDIDFP mune zvinokwana izvi zvinenge 10mg / ml.
Kana zvinodhaka zvigadziriswa zvinotarisirwa kuongororwa kwezvisikwa, zvinogona kuve zvakagadziriswa nekuderedza iyo yega yega yega muzviputi zvakanyanyisa kana isotonic saline. Kuziva kuti inosara yakawanda ye organicsolvent haina kukosha, sezvo zvinokonzerwa nehutachiwana zvingave nezvine utano hwepanyama pahutano hwakadzika. kwete kukurudzira kuchengeta aqueous solution kwezuva rinopfuura rimwe.

4.How IDFP inoshanda?

IDFP inhibitor isingagadziriswi yemhando dzakasiyana-siyana dze enzymes dzinowanzoshanda kuputsa maurotransmitter, asi iyo yakareba alkyl chain ye IDFP inoita kuti zvive zvisina simba sezvinoita inhibitor ye-acetylcholinesterase (AChE), nepo inhibitor inonyanya yemadziviri enzyme monoacylglycerol lipase ( MAGL), iyo enzyme yokutanga inoshandiswa pakusvibisa endocannabinoid 2-arachidonoylglycerol (2-AG), uye mafuta asidi amide hydrolase (FAAH), iyo enzyme yekutanga inoshatisa imwe mainendocannabinoid anandamide. An organophosphorous compound that inhibits MAGL and FAAH with IC50 values ​​of 0.8 and 3 nM, respectively.1 At 10 mg / kg, IDFP inosimudzira hutano hwe 2-AG neAEA kupfuura 10, uye inoderedza mazinga e arachidonic acid 10-fold.

5.Zvava:

Ichi chigadzirwa hachisi chevanhu kana chekushandiswa kwezvokurapa, kumwe kunyevera kuchiri kutsvaga. Dzivisa zvakananga kuganda, meso, mapfupa, kupora chero kupi zvako, tumira chiremba wako pakarepo.

6.IDFP Mushonga Wakawanda:

Min order 10grams.
Inobvunza pamusoro pezvakawanda (mukati 1kg) inogona kutumirwa mumaawa e12 mushure mekubhadhara.
Kuti uwedzere kurongeka kunogona kutumirwa mumazuva ekushanda kwe3 mushure mekubhadhara.

7.IDFP Raw Powder Recipes:

Kubvunzurudza Mutengi wedu Mumiririri (CSR) nezvemashoko, nekuda kwako.

8.IDFP Kutengesa:

Kuti igoverwe mune ramangwana riri mberi.

9.Does IDFP Inobatsira Here?

Iyo renal medulla, inofungidzirwa inonyanya kukosha kwekugadziriswa kwemunyu uye mvura inoyerera uye kwenguva refu yeropa rekudzivirira, inowedzera mu anandamide uye maviri ayo makuru makuru enzyme enzyme, cyclooxygenase-2 (COX-2) uye mafuta acid amide hydrolase (FAAH) . Kuvharirwa kwe anandamide (15, 30, uye 60 nmol · min-1 · kg-1) mu renal medulla yeC57BL / 6J mice yakasimudzira diuresis uye munyu wechuru muCXX-2-asi kwete COX-1. Kuti aone kana endogannabinoid inogumira mumaral medalla inogona kuita mamiriro akafanana, zvinokonzerwa ne intramedullary isopropyl dodecyl fluorophosphate (IDFP), iyo inhibisa maviri ekupedzisira endocannabinoid hydrolases, yakadzidzwa. IDFP mishonga yakakonzera urini maitiro ekugadzirisa uye sodium yakanyanya mu COX-2-asi kwete COX-1-inotenderera. Hazvinawo anandamide kana IDFP yakakonzera glomerular filtration rate. Nhamba yemagetsi (0.625 mg · kg-1 · 30 min-1 iv) kana intramedullary (15 nmol · min-1 · kg-1 · 30 min-1) IDFP kufambidzana mberi kwe intramedullary anandamide (15-30 nmol · min-1 · kg-1) zvakanyatsovharwa migumisiro ye anandamide, zvichiratidza kuti hydrolysis ye anandamide yakanga isingakwaniki pakuita kwayo diuretic. Intramedullary IDFP yakanga isina simba pamusoro pesimba rekubuda ropa asi yakakurudzira renal medullary ropa kufamba. Migumisiro yeDFFP pamusana wekuyerera kwechirwere uye medullary blood flow yaiva FAAH-inotarisirwa sezvakaratidzwa kushandisa FAAH kugogodza mice. Kuongororwa kwepinjini urinary PGE2 kuwirirana neHPLC-electrospray ionization tandem mass spectrometry yakaratidza kuti chirongwa cheDFFP chakaderedza urinary PGE2 Iyi data inopindirana nebasa re FAAH uye rinogumira anandamide richiita neCONX-2-inotenderera metabolite kuti igadzirise diuresis uye salt excretion mu mousekidney.


III. IDFP HNMR

Isu Aprepitant powder supplie, Aprepitant poda yekutengesa, Raw Aprepitant powder (170729-80-3) hplc =98% | Yakarura R & D Reagents


IV. Ungatenga sei IDFP kubva kuAASraw?

1.Kutaurirana nesu ne email yedumvumo yekubvunzurudza, kana kuti inotenga skypeMutariri wevashandi (CSR).
2.Kutipa isu yakabvunzwa nekero.
3.Our CSR ichakupa iyo quotation, nguva yekubhadhara, nhamba yekutsvaga, nzira yekuendesa uye inofungidzirwa zuva rekuuya (ETA).
4.Payment yakaitwa uye zvigadzirwa zvichaendeswa mumaawa e12 (Kurongeka mukati me10kg).
5.Goods inogamuchira uye inopa mhinduro.


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Zvimwe tsanangudzo pamusoro pezvinhu zvakakosha zvemiti,gamuchirai kuti munyore pano.


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