Lenvatinib powder (417716-92-8) - Mugadziri Fekitori Mutengesi
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Lenvatinib

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Lenvatinib powder is a receptor tyrosine kinase (RTK) inhibitor iyo inotitadzisa zviitiko zvekinase zvevascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), uye VEGFR3 (FLT4).

Product Description

Basic Hunhu

Product Name Lenvatinib upfu
CAS Number 417716-92-8
Molecular Formula C21H19ClN4O4
Formula Weight 426.85
Synonyms 417716-92-8;

E7080;

E7080 (Lenvatinib upfu);

4-[3-Chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide;

Kuonekwa Muchena kusvika pachena-poda yakachena
Kuchengeta uye Kubata Zvichengetedze pamhepo tembiricha uye kure nekupisa kwakanyanya uye hunyoro.

 

Lenvatinib Powder Tsananguro

Lenvatinib powder mushonga unorwisa kenza wekurapa mamwe marudzi ekenza yehutachiona uye nemamwewo kanzira. Yaive ichiita seyakawanda kinase inhibitor inopesana neiyo VEGFR1, VEGFR2 uye VEGFR3 kinases.

Lenvatinib powder rudzi rwekurapa kwakanangwa. Izvi zvinoreva kuti inovavarira chimwe chinhu chakanangana nemaseru ekenza, nekudaro kudzikira kwemhedzisiro inokonzerwa nekukuvara kune maseru ane hutano. Lenvatinib powder inoshanda nekuvhara maitiro maviri anotendera cancer maseru kukura:

▪ Kukanganisa puroteni inokurudzira kupatsanurwa kwemasero

▪ Kuvharira receptor yeVEGF, inoona nezve angiogenesis, kana kukura kweropa kutakura. Izvi zvinobvisa bundu kwarinobva manyukunyuku.

 

Lenvatinib Powder Maitiro Ekuita

Lenvatinib powder is a receptor tyrosine kinase (RTK) inhibitor iyo inotitadzisa zviitiko zvekinase zvevascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), uye VEGFR3 (FLT4). Lenvatinib powder zvakare inodzivirira mamwe maRTK akave akabatanidzwa mune pathogenic angiogenesis, bundu kukura, uye kenza kufambira mberi mukuwedzera kune avo akajairwa maseru mashandiro, kusanganisira fibroblast kukura factor (FGF) receptors FGFR1, 2, 3, uye 4; iyo platelet yakatorwa kukura chinhu chinogamuchira alpha (PDGFRcy), KIT, uye RET.

 

Lenvatinib Powder Kunyorera

♦ Kurapa kwevarwere vane kwazvino kudzoka kana metastatic, inofambira mberi, radioactive iodine-inoratidzira kusiyanisa cancer yekenza.

♦ Mukubatana nemushonga everolimus, wekurapa kwepamberi renal cell carcinoma inotevera imwe yekutanga anti-angiogenic therapy.

♦ Kurapa kwehepatocellular (chikuru chiropa) kenza.

♦ Mukubatana nemushonga pembrolizumab yekurapa kwevarwere vane gomarara repamberi remendometri.

Ongorora: Kana mushonga wabvumidzwa kushandiswa kumwe chete, vanachiremba vanogona kusarudza kushandisa iwoyu mushonga kune mamwe matambudziko kana vachitenda kuti anogona kubatsira.

 

Lenvatinib Powder Side Mhedzisiro & Yambiro

Tsvaga rubatsiro rwezvehutano rwekukurumidzira kana iwe une zviratidzo zvehutano hunoita: mikoko; kufema kwakaoma; kurira kwechiso chako, miromo, rurimi, kana huro.

Vamwe vanhu vanotora lenvatinib powder vakagadzira pendi (gomba kana kubvarura) kana fistula (nzira isina kujairika) mukati medumbu kana ura. Dana chiremba wako kana iwe uine kurwadziwa kwakanyanya kwemudumbu, kana kana iwe uchinzwa kunge urikukachidzwa nekugwinha kana uchidya kana kunwa.

 

Danaidzawo chiremba wako kamwechete kana iwe uine:

▪ manyoka akanyanya;

▪ kutemwa nemusoro, kuvhiringidzika, kuchinja mamiriro epfungwa, kurasikirwa nemaziso, kufenda (kugwinha);

▪ kuita weti shoma kana kusaita;

▪ kubuda ropa zvisina kujairika (kubuda ropa mumhino, kubuda ropa kwakanyanya kumwedzi), kana kumwe kubuda ropa kusingamiri;

Zviratidzo zvekubuda ropa mudumbu - zvituru zvine ropa kana zvekumira, kukosora ropa kana kurutsa zvinoita senzvimbo yekofi;

▪ matambudziko emwoyo - kurwadziwa kwepfupa, kurwadziwa mushaya kana pabendekete, kuzvimba, kuwedzera uremu nekukurumidza, kunzwa kufema kwekufema;

▪ zviratidzo zvekuvhara kweropa-kamwe kamwe kushaya simba kana kushaya simba, matambudziko ekuona kana kutaura;

▪ matambudziko echiropa- weti yakasviba, zvituru zvine ruvara rwevhu, jaundice (yero yeganda kana maziso);

▪ yakaderera calcium level-mhasuru spasms kana contractions, chiveve kana kushushikana kunzwa (kutenderedza muromo wako, kana muzvigunwe nezvigunwe);

▪ kuwedzerwa kweBP - kutemwa nemusoro kwakakomba, kusaona zvakanaka, kurova muhuro kana nzeve, kushushikana, kubuda ropa mumhino.

Zvirwere zvako zvegomarara zvinogona kunonoka kana kumiswa zvachose kana uine mamwe mhedzisiro.

 

Misungo yakajairika inogona kusanganisira:

▪ kubuda ropa;

▪ kurwadziwa nemudumbu, kuda kurutsa, kurutsa, manyoka;

▪ kushaya nzara, kushaya muviri;

▪ kuongororwa kwehutano hwehutachiona;

▪ kurwadziwa kwemhasuru kana kwemajoini;

▪ kuzvimba mumaoko nemakumbo;

▪ maronda emuromo;

▪ kutsvuka, kuchenesa, kana kubvisa ganda pamaoko ako kana mutsoka;

▪ kutemwa nemusoro, kuneta;

Kosora, kunetseka kufema, izwi rakashoshoma.

Iri haisi rondedzero yakazara yemigumisiro uye vamwe vanogona kuitika. Dana chiremba wako kune mazano ekurapa nezvemigumisiro. Iwe unogona kuudza migumisiro yakaipa kune FDA pane 1-800-FDA-1088.

 

Reference

[1] US Kudya neDrug Administration. Hematology / Oncology (Cancer) Kubvumidzwa & Kuchengetedzwa Notification.

[2] Haberfeld H, ed. (2015). Austria-Codex (muchiGerman). Vienna: Österreichischer Apothekerverlag.

[3] "Lenvatinib powder pamwe chete ne Everolimus" US Kudya neDrug Administration. 16 Chivabvu 2016.

[4] Kliniki yekuyedza nhamba yeNCT01321554 ye "Muedzo weE7080 mu131I-Refractory Yakasiyanisa Kenza yeTiroid" kuClinicalTrials.gov.

[5] Lubitz CC, Kong CY, McMahon PM, et al. Yegore rega yemari kukanganisa kweakasarudzika musiyano kenza yehutachiona muUnited States. Gomarara. 2014; 120: 1345–1352.

[6] Lenvima (lenvatinib powder) makapisi [achiisa ruzivo]. Woodcliff Lake, NJ: Eisai Inc; Kukadzi 2015.

[7] Eisenhauer EA, Therasse P, Bogaerts J, et al. [1.1] Nyowani mhinduro yekuongorora maitiro mumatumbu akasimba: akagadziridzwa RECIST nhungamiro (vhezheni 2009). Eur J Kenza. 45; 228: 247-XNUMX.

[8] Schlumberger M, Tahara M, Wirth LJ, et al. Lenvatinib powder maringe ne placebo mu radioiodine-inoratidzira cancer kenza. N Engl J Med. 2015; 372: 621-630.