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Lorcaserin (Belviq) powder

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3.50 kupererwa ne 5 maererano ne 2 kasitoma ratings
SKU: 616202-92-7. Category:

ICHINYANYA ndechekugadzirisa uye kugadzira zvigadzirwa kubva ku gram kusvika kukura kwe Lorcaserin (Belviq) powder (616202-92-7), pasi peCGMP mutemo uye nehutsika hwehutano hwehutsika.

Product Description

Lorcaserin Kutanga

Kubudisa kushanda kwakasimba uye kwakachengeteka kurasikirwa kwemishonga ibasa rinotyisa. Kuedza munguva yakapfuura kwakauya nemigumisiro yakawanda yakadai sekushaya mwoyo. Nenguva isipi, chidzidzo chitsva chinoreva kuti lorcaserin kuora mwoyo piritsi inogona kukubatsira kuti ude kurema uremu husingaiti kunze kwekuti ugoba nehutano hwemoyo wako. Lorcaserin inoshamisa chishuwo chekushaya piritsi, iyo yakagamuchirwa neDDA mu 2012. Asi chii chinonzi lorcaserin? Zvakanaka, pasi apa tsanangudzo yakadzama yechirwere, chimiro chemakemikari uye nzvimbo, inoshandisa, kuyerwa, kuchenjerera, nezvimwe zvakawanda.

Zita reMiti: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Lorcaserin (Belviq) powder video


I.Lorcaserin (Belviq) powder Basic Characters:

Name: Lorcaserin (Belviq) powder
CAS: 616202-92-7
Molecular Formula: C11H14ClN
Molecular Weight: 195.692
Melt Point: 212 ° C
Storage Temp: RT
Color: Muchena kusvika pachena-poda yakachena


Lorcaserin Kutanga

Kubudisa kushanda kwakasimba uye kwakachengeteka kurasikirwa kwemishonga ibasa rinotyisa. Kuedza munguva yakapfuura kwakauya nemigumisiro yakawanda yakadai sekushaya mwoyo. Nenguva isipi, chidzidzo chitsva chinoreva kuti lorcaserin kuora mwoyo piritsi inogona kukubatsira kuti ude kurema uremu husingaiti kunze kwekuti ugoba nehutano hwemoyo wako. Lorcaserin inoshamisa chishuwo chekushaya piritsi, iyo yakagamuchirwa neDDA mu 2012. Asi chii chinonzi lorcaserin? Zvakanaka, pasi apa tsanangudzo yakadzama yechirwere, chimiro chemakemikari uye nzvimbo, inoshandisa, kuyerwa, kuchenjerera, nezvimwe zvakawanda.

Zita reMiti: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Pasi pane chimiro chemakemikari e-lorcaserin mu 3-D kugadzirisa.

Lorcaserin (Belviq) powder

Chemicals Properties yaLorcaserin (belviq) (CAS 616202-92-7)

Pasi apa inopfupikiswa makemikari ezvinhu aLorcaserin (belviq); ivo vakave vaudzwa mu tafura iri pasi apa kuti vatarise nokukurumidza.

Name Name Property Value
Covalently-Bonded Unit Count 1
Isotope Atom Count 0
Kusagadziriswa Bond Stereocenter Count 0
Kunotsanangurwa Bond Stereocenter Count 0
Usingazivikanwi Atom Stereocenter Count 0
Kunotsanangurwa Atom Stereocenter Count 1
Heavy Atom Count 13
Mutemo Wakafanana 0
Compound Is Canonicalized chokwadi
XLogP3-AA 2.7
Misa chaiye 195.081 g / mol
Monoisotopic Mass 195.081 g / mol
Topological Polar Surface Area 12 A ^ 2
Complexity 172
Rotatable Bond Count 0
Hydrogen Bond Acceptor Count 1
Hydrogen Bond Donor Count 1
Molecular Weight 195.69 g / mol
Kusiyanisa Constants

pKa = 9.98 (est)

Tsanangudzo yakajeka ye Lorcaserin HCL powder

Lorcaserin (Belviq) inoda kupisa mapiritsi anokonzerwa neArena Pharmaceuticals. Icho chiri chekirasi remishonga inonzi inonzi serotonin receptor agonists. Yakagadzirirwa kukubatsira kuti unzwe wakakwana mushure mekunge wadya kudya kuduku. Icho chinoderedza chishuwo kuburikidza nekugadzira 5-HT2C receptors, iyo ndiyo mhando dzeredotonin receptors mune imwe nzvimbo yeuropi (hypothalamus) inodzora chido. Apo pavanoratidza kuti muviri wako unonzwa wakakwana, unosvika pakudya zviduku, saka unopedzisira uchirasikirwa mukufamba kwenguva.

Belviq, ane makemikari zita (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride hemihydrate, inoreva kutorwa nomuromo. Iro molecular weight is 241.16 g / mol, uye iyo yakagadzirirwa inonzi C11H15Cl2N • 0.5H2O. Zvinyorwa zvaro zvakanyorwa pasi apa:

Lorcaserin (Belviq) powder

Iyo solubility yaLorcaserin hydrochloride hemihydrate mumvura yakakwirira kupfuura 400 mg / mL. Bheteti yeBelviq ine 10.4 milligrams ye crystalline lorcaserin hydrochloride hemihydrate (mutsvuku kusvika kune-white-off-white powder), iyo yakaenzana ne10.0 milligrams anhydrous lorcaserin hydrochloride. Inosanganisirawo zvimwe zvinosanganisa, kusanganisira magnesium stearate NF, USATC USP, FD & C Blue #2 aluminium lake, titanium dioxide USP, polyethylene glycol NF, polyvinyl alcohol USP, colloidal silicon dioxide NF, silicified microcrystalline cellulose uye hydroxypropyl cellulose NF.

Chiito chekugadzira Lorcaserin

Maererano neKudya uye Drug Administration yekutsanangurira (2007), Lorcaserin inokwanisa kubatsira vanhu vakuru kuti vabudirire kuchipatara chinorema kurasika. Izvi zvinonzi kurasikirwa kwehutano zvinonzi kushanda zvakanaka kana paine huwandu hwekuita muviri uyewo kudya kwema-calorie. Inogona kubatsira zvikuru nekusingaperi kwekutakura, kunyanya nevanhu vane uwandu hwehuwandu (kunyanya 27 kg / m2), kana kuneta (BMI ye30 kg / m2). Iyi mishonga inogonawo kubatsira avo vane imwe kana kuti yakawanda zvine chokuita nehutano, yakadai sorudzi rwe2 chirwere cheshuga, dyslipidemia, kana kuti kuwedzera kwehutano.

Lorcaserin inoratidzira chirwere chinoda kuperesa piritsi iyo inosarudza sechinyakare se 5-HT2C receptor agonist mu hypothalamus nechisarudzo selectivity ye gumi nemashanu zvakanyanya kufanana kwe5-HT2C receptors kupfuura 5-HT2A uye iyopping a 100 nguva yakakwirira yebasa sarudzo ye 5-HT2C receptors kupfuura ye 5-HT2B.

5-HT2C receptors inenge inenge iri muhuropi hwemunhu uye inogona kuwanikwa mune thalamus, hypothalamus, cortex, hippocampus, choroid plexus, cerebellum, uye amygdala. Kukurudzirwa kweA5-HT2C receptors mu hypothalamus activates POMC (proopiomelanocortin) kubudisa uye naizvozvo kukurudzira kuderedza kuyerwa kuburikidza nekuita satiety. Iyi nharo inotsigirwa nezviitiko zvekuchirapa zvinoratidzwa uye zvimwe zvidzidzo zvekutsvakurudza. Kunyange zvazvo inowanzofungidzirwa kuti mumiririri we5-HT2C anobatsira pakugadzirisa kudya, endocrine kuchengetedza, uye mafungiro, kunyatsoita maitiro ekuita chido chekudya hakuzivikanwi.

Receptor EC50 [nM] Ki[nM]
5-HT2C 39 13
5-HT2B 2380 147
5-HT2A 553 92

Kushandisa Lorcaserin HCL powder

Kana tikafunga zvechokwadi reLorcaserin kuongororwa kunze uko, zvino izvi zvinogona kunge zvakanakisisa kuora kwepill pill pamusika nhasi. Vamwe vanhu vane uremu hwemusoro, kureva, avo vane mamiriro ekurapa ane chokuita nekurema kana avo vanorema vanogona kubatsirwa zvikuru nechigadzirwa ichi.

Kana ikashandiswa pamwe chete nechirongwa chechiremba chakabvumirwa kuita basa, chirongwa chekudya chekoriori, uye mararamiro ekuchinja, Lorcaserin inogona kubatsira munhu kuita zvakawanda pane kungoora uremu - zvinogona kubatsira kuderedza ngozi dzakawanda dzehutano dzinobatanidzwa nekuneta, kusanganisira high blood pressure, chirwere cheshuga, chirwere chemoyo, uye kufa kwekutanga.

Maererano neCentral for Disease Control, kurasikirwa kweA5 kusvika ku10 muzana yehutatu hwehutatu hunogona kupa humwe hutano hwehutano hwakadai sekuvandudzwa muropa yehuga, cholesterol yeropa, uye ropa.

Nhamba ye Lorcaserin HCL powder

Vakuru vanofanirwa kutora mapiritsi maviri pazuva. Saka iwe unoda kutora mapiritsi e60 pamwedzi. Maererano neCDA, munhu anofanira kushandisa chiremba panguva yese yehupenyu hwake kuchengetedza uremu hwakanaka.

Zvakakosha kuziva kuti zviitiko zvakanaka zvinofanira kuonekwa mushure memasvondo e12. Kana iwe uchinge usina kurasikirwa zvishoma ne5 muzana yemuviri wako wekutanga wekutanga wekutanga, iwe unorayirwa kurega kushandisa mapiritsi. Kunyangwe nekupfuurira kushandiswa, hazvisi zvishoma kuti iwe uchawana nekuchengetedza makiriniki anorema kuora kurasikirwa.

Lorcaserin HCL Kuchengetedza

Zvakanaka kuyeuka kuti nyanzvi yako yehutano yakarongedza iyi mishonga nokuti vakaona kuti kubatsirwa kwaunowana kune yakakwirira kune ngozi dzehuipi. Vanhu vazhinji vanotora zvinodhaka izvi havaratidzi zvikanganiso zvakakomba.

Usati watora lorcaserin, rega mushonga wako wemishonga kana chiremba azive kana iwe uri weergorgia kune zvinodhaka; kana kuti iwe une chimwe chimwe chirwere. Lorcaserin ine zvigadzirwa zvisingaiti zvinogona kutungamirira kumagariro evanhu kana zvimwe zvinetso. Kumbira mhizha wako kuti akupe zvakawanda.

Usati watora ichi chemishonga, udza chiremba wako kana chiremba nezvehutano hwako hwehutano, kunyanya kwezvinetso zvepoyo, chirwere cheshuga, chirwere cheropa, chirwere chemwoyo (kusanganisira moyo wemwoyo, chirwere chepfungwa chepfungwa, kunonoka kwemoyo, mwoyo kusakundikana) zvinogona kuwedzera ngozi erections inorwadza / yakareba muvarume (kusanganisira chirwere chinoparara, chirwere chePeyronie, multiple myeloma, sickle cell anemia, leukemia).

Ichi chido chinodzvinyirira mapiritsi chinogona kukuita kuti iwe unonoke kufunga kwako kana chizoro. Marijuana kana doro zvinogona kuita kuti izvi zviwedzere kuipa. Usashandise mitambo, kutyaira, kana kuita chimwe chinhu chinokumbira kusvinura kusvikira wava kukwanisa kuzviita zvakanaka. Deredza zvinwiwa zvinodhaka uye taura nachiremba wako kana uri kushandisa mbanje.

Kana iwe uchizoita chirongwa chekuvhiya, kuchenjera kuti iwe uudze chiremba wemazino kana chiremba nezvezvinhu zvose zvaunotora (kusanganisira zvisingashandisi zvinodhaka, mishonga yemishonga, uye mishonga yemishonga).

Kana uri kurarama nechirwere cheshuga, iyi piritsi inorema inogona kuchinja shuga yako yeropa. Iva nechokwadi chekutarisa uwandu hwehuga hweropa rako nguva dzese sezvaunorayirirwa uye kugovera zviwanikwa zvako nachiremba. Rega chiremba wako azive kana une zviratidzo zvehuga zvepasi. Utano hwako hwehutano hunogona kudikanwa kuti ugadzire chirongwa chako chekushandisa, chironga kana chirwere cheshuga.

Ichi chemishonga hachifaniri kutorwa panguva yekuzvitakura nokuti inogona kukuvadza mwana asati aberekwa. Kumbira chiremba wako nezvekushandiswa kwemaitiro akavimbika ekudzivirira kuberekwa. Kana iwe uri nepamuviri kana kuti wava nepamuviri, taurira unyanzvi hwehutano hwako pakarepo.

Kusvika ikozvino, hazvizivikanwe kana ichi chinodhaka chinopinda mumukaka wemvere. Kuchengetedza kukanganisa kwengozi kumucheche, kunwisa kana kushandisa mishonga iyi hakukurudzirwi. Iva nechokwadi chokuti unobvunza chiremba wako usati wamuyamwisa.

Verenga Bhuku reMashoko eZvamwe zvakanyatsonaka kana richiwanikwa kubva kunachiremba usati watanga kushandisa lorcaserin uye chero nguva yaunowana. Kana iwe uine mubvunzo upi, bvunza chiremba wako kana chiremba.

Tora chido ichi chinodzvinyirira piritsi nemuromo kana kuti pasina kudya sezvinorayirwa nemumwe wemasvomisti, kazhinji kaviri pazuva. Shandisa izvi zvinodhaka nguva dzose kuti uwane zvakanyanya. Kuti ikubatsire kuyeuka, tora mapiritsi panguva imwe chete zuva rimwe nerimwe.

Lorcaserin chirongwa chekuita tsika. Usawedzere chido kana kutora piritsi iyi kakawanda pane yakatemwa. Mamiriro aunayo haafaniri kuvandudza chero ipi zvayo nokukurumidza, uye ngozi yemigumisiro inogona kuwedzera.

Kubatana kwakanyanya kwemishonga kunogona kuitika apo mamwe madhiragi anoshandiswa pamwe ne lorcaserin piritsi. Taurira chiremba wako pamusoro pemishonga yose yaunoshandisa ikozvino, uye chero imwe mishonga inotanga iwe kana kumisa kushandisa.

Lorcaserin kuora kurasikirwa kwepiritsi haisi kubvumidzwa kuti ishandiswe nevanhu vakadarika makore anopfuura 18.

Ndinofanira kutora sei Lorcaserin HCL powder?

Usatsvaga, kuputsa, kana kupwanya piritsi yakasunungurwa-yakareba. Ingoimedza zvachose.

Lorcaserin chido chokudzvinyirira chinongova chikamu chepurogiramu yakakwana yekurapa iyo inofanirawo kusanganisira muviri, kurerisa, kudya, uye nguva dzose kuedza shuga yako yeropa. Tevera mishonga yako, kudya kunovaka muviri, uye miitiro yekushanda zvakaoma chaizvo.

Chengetedza mishonga pakushambidzwa kwemajeri kure nekupisa uye unyoro.

Chengetedza zvinyorwa zvehuwandu hwezvinodhaka zvinoshandiswa kubva mumabhodhoro ose. Lorcaserin kuora kurasikirwa piritsi ndeyekushandisa zvinodhaka, uye iwe unofanirwa kuziva nguva dzose kana mumwe munhu ari kushandisa mushonga wako pasina chiremba kana zvisina kunaka.

Usambofa ugovana mushonga we lorcaserin nemumwe munhu. Chengetedza mishonga munzvimbo umo pasina mumwe munhu anogona kuiwana.

Chii chinoitika kana iwe ukarasa Lorcaserin dose?

Ingotora mazamu asina kumira pakarepo iwe uchiyeuka. Iwe unofanirwa kutsika chirasi chakakanganwa kana nguva yenguva inotevera yakagadziriswa inenge yava pedyo. Usatora imwe mazamu kuti uzviitire murasi inoshaiwa.

Chii chinoitika kana iwe unodarika waLorcaserin?

Tsvaga rubatsiro rwemhizha rwekukurumidza kana kuti taura nePoison Help line pa 1-800-222-1222.

Ndechipi chandinofanira kudzivisa kutora paLorcaserin?

Usatora chero chimwe chepamusoro-che-chiremba kana chiremba chiremba-kurasikirwa kwemishonga pasina zano rechiremba wako. Uyewo, usatora mishonga inotonhora kana yekodha kana uchitora lorcaserin mapiritsi.

Ndeapi mamwe mishonga inogona kuchinja lorcaserin?

Mishonga inotevera inogona kukanganisa kuti lorcaserin inoshanda sei:

  • A "triptan" iyo inonzi migraine misoro yemusoro-yakadai saMaximalt, Zomig almotriptan, rizatriptan, sumatriptan, frovatriptan, zolmitriptan, Imitrex, nevamwe.
  • Cabergoline;
  • linezolid;
  • chero chero rudzi rweanodzvinyirira
  • lithium;
  • John's wort;
  • erectile dysfunctiondrugs- Levitra, Viagra avanafil, Cialis, sildenafil, tadalafil, nevamwe;
  • tramadol;
  • tryptophan (inozivikanwawo seL-tryptophan);
  • kugunun'una kana mishonga inotonhora ine dextromethorphan; kana
  • mishonga yekurapa zvirwere zvepfungwa, manzwiro kana dambudziko rekuzvidya mwoyo.

Urongwa huri pamusoro hahuwandu. Mamwe mishonga inogona kukanganisa lorcaserin, uye kwete kushamwaridzana kwose kunogona kuve kwakanyorwa mumutungamiri wemishonga iyi.

BBC Reports Pamusoro Pokuchengetedza uye Kubudirira kwaLorcaserin HCL (CAS 616202-92-7)

Pakave nenhau dzakawanda dzeBBC pamusoro peLorcaserin pamusoro pekusaitika chete asi nekuchengetedzwa kwemishonga. Maererano neBBC, kuongorora kwechangobva kuitika, kwakabudiswa muNew England Journal of Medicine, inoratidza vanhu vachishandisa lorcaserin chido chekupedza mapiritsi vakarasikirwa nehuwandu hweHNUMXlb (8.8kg) pamusoro pekanguva yenguva shomanana makore matatu nehafu. Migumisiro yenyaya iyi yakaratidza kuti lorcaserin hapana mubvunzo chimwe chezvinhu zvakanakisisa kurasikirwa mapiritsi.

Mushumo unotiwo mushonga sezvo unoshanda nekudzivisa kudya kudya, usaisa vashandisi vari pangozi yepamamiriro ezvinhu emwoyo. Kuongorora kwakabudiswa kwakazotevera kukonzera 12,000 obese kana varwere vanopfuura kwereight muU.SA kwemwedzi ye40.

Pashure pemakore matatu nehafu, vanhu vakuru vachitora lorcaserin vaiwanzoita katatu kupfuura kuti vasati vadzikisa zvishanu kusvika gumi kubva muzana yemuviri wavo kupfuura avo vanogamuchira nzvimbo yebasa, maererano nomumwe wevatungamiri vekuongorora, Dr. Erin Bohula.

Miedzo yakaitwa pamwoyo valve haina kuratidza chero zvakasiyana zvakasiyana kana ichienzaniswa nemapapiro emwoyo evaya vanotora placebo. Tichifunga kuti iyi ndiyo ndiyo yainyanya kukoshesa kana iri pamusoro pokuchengetedzwa kwemamwe mapiritsi asingakanganisi, lorcaserin inogona kuva yakanakisisa yekurasikirwa piritsi.

Vanhu vakuru vanotora mishonga vakanga vari pangozi yakaderera yerudzi rwe 2 chirwere cheshuga. Iyo piritsi inodhura makambani ane £ 155-225 ($ 220-290) pamwedzi mwero muUnited States. Lorcaserin inopa imwe nzira yakanakisisa kune zvinoparadza zvinorema-kuderedza nzira dzakadai sekugadzirwa kweboka rekugadzira pakati pevamwe.

Mumwe mushumo weBBC wakataura nezvekutsvakurudza kwakaitwa nevatsvakurudzi paYunivhesiti yeAberdeen yeRotttt Institute iyo yakaita tsvakurudzo nezvekudya. Masayendisiti akati kushandiswa kwavo pamusoro pekudya kwaive kwavatungamirira kune chimwe chikamu cheuropi.

Vakacherechedza kuti kuburikidza nekufurira masero aya chaiwo nemishonga ivo vakakwanisa kuderedza kudya kwekudya. Sezvo lorcaserin inoshanda nenzira iyi, migumisiro yechirongwa ichi haina kungozarura masuo emishonga mitsva yakadai sa lorcaserin asi zvakare yakasimbisa izvo nyanzvi dzinotenda pamusoro pe lorcaserin -kuchengeteka kwayo uye kubudirira.

KUGADZIRIRA UYE KUDZIDZA:

Ichi Chinyorwa Kutengeswa Kwekutsvagisa Chete Chete. Mitemo Yekutengesa Nyorera. Kwete Yekushandiswa Kwevanhu, kana Kurapa, Veterinary, kana Kushandisa Kweimba.


COA

HNMR

Isu tiri Lorcaserin powder vapeji, Belviq powder kutengesa, (616202-92-7) hplc =98% | AASraw slimming HNMR

AAS yakasvibiswa inopa kuchena 98% Lorcaserin pfumbu yakasvibirira kuti vashandise muviri kana pasi pevhu kune fweight-kurasikirwa kushandiswa.

Recipes

References & chigadzirwa mhizha

Lorcaserin powder: Zvinhu zvose pamusoro pemafuta kurasikirwa nemishonga

Lorcaserin migumisiro: Ko Lorcaserin powder inonyatsoshanda nekuda kwekurasikirwa kwemafuta here?

Zvinhu zveCNUMX zvakakosha Zvaunofanira kuziva nezve Lorcaserin HCL powder

Bibliographie

  1. Weissman NJ, Sanchez M, Koch GG, et al. Echocardiographic muongorori wepachiviripu valvular kudzokerazve ne lorcaserin kubva kuongororwa kwe3 chikamu 3 mishonga yekliniki. Circ Cardiovasc Imaging 2013; 6: 560-7
  2. Halford JC: Kuwedzerwa kwemishonga yemishonga mukugadzirwa kwekliniki. Curr Opin Investig Zvinodhaka. 2006 Apr; 7 (4): 312-8.
  3. Thomsen WJ, Grottick AJ, Menzaghi F, et al. Lorcaserin, inoverengeka inosarudza vanhu 5-hydroxytryptamine2C agonist: in vitro uye in vivo kugadziriswa kwemasvomhu. J Pharmacol Exp Ther 2008; 325: 577-87
  4. Smith BM, Smith JM, Tsai JH, et al. Kuwana nekugadzirisa-basa rehukama hweLorcaserin, serotonin inosarudza 5-HT2C receptor agonist yekurapa kuneta. J Med Chem 2008; 51: 305-13
  5. BBC News, "A Boka duku reboka reuropi rinogona kukwanisa kuderedza kuneta maererano neAberdeen vatsvakurudzi. "