MMAD (Demethyldolastatin 10)

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ICHINYANYA ndechekugadzirisa uye kugadzira zvigadzirwa kubva ku gram kusvika mukurongeka kweMMAD (Demethyldolastatin 10) (CAS 203849-91-6), pasi peCGMP mutemo uye nehutsika hwehutano hwehutsika.

Uyezve, MMAD inonzi inoshandiswa mukugadzirwa kwenzvimbo-inonzi anti-anti-drug conjugates (NDCs). Mune NDCs, MMAD inosanganiswa ne anti-5T4 antibody kana anti-Her2 antibody. Inoratidzirwa kuti iyo NDCs inoratidza huri nani hwekuita uye pharmacokinetics.

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MMAD (Demethyldolastatin 10) video


I.MMAD (Demethyldolastatin 10) basic Characters:

Name: MMAD (Demethyldolastatin 10)
CAS: 203849-91-6
Molecular Formula: C41H66N6O6S
Molecular Weight: 771.06
Melt Point: N / A
Storage Temp: Poweri -20 ° C 3 makore
4 ° C 2 makore
Mukusanganiswa -80 ° C 6 mwedzi
-20 ° C 1 mwedzi
Color: Yakachena kusvika kune-yakachena (yakasimba)


II. MMAD (Demethyldolastatin 10) (203849-91-6) kushandiswa mu steroid cycle

1.Names:

Dhiyabhorosi: Demethyldolastatin 10 (203849-91-6); Monomethylauristatin D; Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

2.MMAD (Demethyldolastatin 10) Kushandisa:

3.Zvava nezveMMAD (Demethyldolastatin 10)

Chigadzirwa hachina kugadziridzwa zvizere nokuda kwekushandiswa kwechiremba. Kutsvakurudza kunoshandisa chete

Kuti uwane kuvhara kwepamusoro, tapota furai tube mu 37 ℃ uye muizunungure muwaini ye ultrasonic kwekanguva.Solution solution inogona kuchengetwa pasi -20 ℃ kwemwedzi inoverengeka.

4.kuwedzera mirayiridzo:

In Vitro: MMAD (Demethyldolastatin 10) (203849-91-6) inobatanidza kuburikidza nehutano hwakagadzikana hwe-oxime-ligation kuti ibudise huwandu hwemagetsi anonzi anti-anti-drug conjugates (ADCs) nechirwere chemishonga-kusvika-antibody che ~ 2.0. Izvozvo zvinogadziriswa zvinoratidzira zvakanaka pharmacokinetic properties, zvakanyanya in vitro cytotoxic basa rinopesana neHER2 + kenza dzemasero. Kana ichienzaniswa neADCs yakagadzirirwa ne-cysteine ​​alkylation inotevera nharaunda inopinda disulfide kuderedza, nzvimbo-chaiyo isina kusimba-amino-acid-based ADCs inoratidzwa kuti yakawedzera mu vitro cytotoxicity

MuVivi: Izvozvo zvinokonzerwa nehutachiona-zvinokonzerwa nemishonga (ADCs) zvinoratidza chiremera chakakwana chechirwere mumakonzo. Izvo zvakare vane huwandu hwakanyatsonaka hwehuwandu hwezvinyorwa mumakonzo.


III. MMAD (Demethyldolastatin 10) (203849-91-6) HCML

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IV. Nzira yekutenga MMAD; kutenga Demethyldolastatin 10 kubva kuAASraw?

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