Raw MMAF (Hydrochloride) (1415246-68-2) HPLC≥98% | AASraw
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MMAF (Hydrochloride) (1415246-68-2)

Rating: SKU: 1415246-68-2. Category:

MUTSVENE unobatanidzwa uye unokwanisa kugadzira kubva ku gramu kusvika mukurongeka kweMMAF (Hydrochloride) (CAS 1415246-68-2), pasi pemutemo weCGMP uye nehutsika hwehutano hwehutsika.

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Product Description

 

MMAF (Hydrochloride) video

 

 


 

MMAF (Hydrochloride)

 

Name: MMAF (Hydrochloride)
CAS: 1415246-68-2
Molecular Formula: C39H66ClN5O8
Molecular Kurema: 768.42
Melt Point: 314.3 ° C pa 760 mmHg (Yakagara yataurwa)
Storage Temp: Poweri -20 ° C 3 makore
4 ° C 2 makore
Mukusanganiswa -80 ° C 6 mwedzi
-20 ° C 1 mwedzi
Color: White crystalline powder

 


 

MMAF (Hydrochloride) kushandiswa mune steroids

 

Mazita

MMAF (Hydrochloride) (1415246-68-2) inonziwo Monomethylauristatin F Hydrochloride, MMAF HCL

 

MMAF (Hydrochloride) Kushandisa

Nyanzvi yezvokurapa inoita rese reseach paMMAF, pano pasi pane mamwe mazwi ekutaura:
In Vitro: MMAF inoratidzira mu vitro cytotoxicity kune rimwe boka remasero esero. Iyo IC50 tsika dze Karpas 299, H3396, 786-O uye Caki-1 dzinonzi 119, 105, 257, uye 200 nM, pamwe chete. Targeted MMAF yakawanda kwazvo kupfuura mushonga wekusununguka, uye kuti cAC10 mazano eMMAF akaratidzirwa mabasa. Pamusana pemaitiro, cAC10-L1-MMAF4 inokwana ye-2200-yakanyanya kupfuura yeMAFAF isingabhadhara uye inoshanda pane dzose CD30-positive cell lines yakaedzwa

MuVivo: Iyo yakanyanya kubvumidzwa muyero mumakonzo eMMAF (1415246-68-2) (> 16 mg / kg) yakakwira zvakanyanya kupfuura MMAE (1 mg / kg). cAC10-L1-MMAF4 ine MTD ye50 mg / kg mumakonzo uye 15 mg / kg mumakonzo. Iyo inoenderana cAC10-L4-MMAF4 ADC yaive isinganyanye kuchetura, iine MTDs mumakonzo nemakonzo e> 150 mg / kg uye 90 mg / kg mumakonzo, zvichiteerana.

 

Yambiro pamusoro peMMAF (Hydrochloride)

Kune tsvakurudzo yakashandiswa chete

 

Mamwe mirayiridzo

Iyo yakanyorwa kuti Monomethylauristatin F Hcl (MMAF Hcl) inhengo ye antitubulin iyo inodzivisa kupatsanurwa kwemazana nekudzivirira kuporesa kwehuturu; uye basa recytotoxic rakaderera kupfuura MMAE; uye inonzi anti-antibody drug cytotoxin.

Cell Assay
Masero anorapwa nema serial dilution emamuedzo mamorekuru uye akafukidzwa mazuva 4-6 zvichienderana nesero mutsara. Kuongororwa kwekukura kwemaseru uye kuderedzwa kwedata kugadzira IC50 kukosha kunoitwa uchishandisa Alamar Bhuruu dhayi kudzikisira muyedzo
MCE haina kumbozvimiririra yakatsigira kuve kwakarurama kwezvi nzira. Ivo ndeyekutaura chete.

Animal Administration
Makonzo: kudzidza kunoratidza kuti kana subcutaneous Karpas 299 tumarara saizi inosvika 300 mm3, mhuka nhatu paboka dzinogamuchira jekiseni rimwe chete re10 mg antibody chinhu / kg uremu hwemuviri wecAC10-L1-MMAF4 kana cBR96-L1-MMAF (1415246-68-2 ) 4 nomutsinga. Mamota anobva abviswa oiswa munzvimbo yakanakisa yekucheka tembiricha, uye 5 μm-dzakaonda zvikamu zvechando zvakaomeswa uchishandisa immunohistochemistry kuongorora
MCE haina kumbozvimiririra yakatsigira kuve kwakarurama kwezvi nzira. Ivo ndeyekutaura chete.

 


 

Nzira yekutenga MMAF; Tenga Hydrochloride kubva kuAASraw

 

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