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Orlistat powder

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SKU: 96829-58-2. Category:

MUTSVENE unobatsira nekugadzira zvigadzirwa kubva ku gram kusvika kuhutano hwehu Orlistat powder (96829-58-2), pasi peCGMP mutemo uye trackable quality control system.

Orlistat powder iyo yakagadzirwa yakakwana ye lipstatin, inowanzo inhibitor inhibitor ye pancreatic lipases yakasarudzwa kubva kubhakitiriya Streptomyces toxytricini. Orlistat chirwere chinogadziriswa kurapa kuneta. Zvisinei, nemhaka yerurimi rwaro rwakazosimbiswa, orlistat yakasarudzwa pane lipstatin yekusimbiswa sechirwere chinopesana nekuwedzeredza.

Product Description

Product Description

KUGADZIRIRA UYE KUDZIDZA:

Ichi Chinyorwa Kutengeswa Kwekutsvagisa Chete Chete. Mitemo Yekutengesa Nyorera. Kwete Yekushandiswa Kwevanhu, kana Kurapa, Veterinary, kana Kushandisa Kweimba.

Orlistat powder video


Orlistat powder Basic Characters

Name: Orlistat powder
CAS: 96829-58-2
Molecular Formula: C29H53NO5
Molecular Weight: 495.7
Melt Point: 50 ° C
Storage Temp: 2-8 ° C
Color: White powder


Zita reMiti: Orlistat

IUPAC Name: [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate

Orlistat Kutanga

Vanopfuura hafu yepasi rose vanove vakamboedza purogiramu yekutakura, zvakadai sekudya, kudzidzira, kuvhiya, kana mishonga. Zvose izvi maitiro ekurasikirwa kwehutano zvinoshanda chete kana iwe wakatendeka kwavari uye uchitevera mirayiridzo kune iyo yekupedzisira. Zvisinei, kusarudza kwekuvhiya kana mishonga inogona kuitika kuti inokuvadza kana iwe usingatori matanho akawanda.

Chimiro chimiro cheOrlistat (3-D kugadzirisa)

Chimiro chimiro cheOrlistat (2-D kugadzirisa)

Makemikari zvinhu zveOrlistat

Name Name Property Value
Covalently-Bonded Unit Count 1
Isotope Atom Count 0
Kusagadziriswa Bond Stereocenter Count 0
Kunotsanangurwa Bond Stereocenter Count 0
Usingazivikanwi Atom Stereocenter Count 0
Kunotsanangurwa Atom Stereocenter Count 4
Heavy Atom Count 35
Mutemo Wakafanana 0
Compound Is Canonicalized chokwadi
XLogP3-AA 10
Misa chaiye 495.392 g / mol
Monoisotopic Mass 495.392 g / mol
Topological Polar Surface Area 81.7 A ^ 2
Complexity 579
Rotatable Bond Count 23
Hydrogen Bond Acceptor Count 5
Hydrogen Bond Donor Count 1
Molecular Weight 495.745 g / mol

Inotsanangurwa yakajeka yeOrlyatat powder

Mumwe kuora kurasikirwa nemishonga kuti iwe uchasangana mukutsvaga kwako kuti uwane hutano hwakakosha hwekutarisira mishonga ndeye Orlistat. Muchidimbu ichi cheOrlistat, uchawana ruzivo rwakakosha, kusanganisira kuti chii, kuti runoshanda sei, uye kuti runofanira kushandiswa sei, kuitira kuti iwe ugone kusarudza kana chiri chakanaka chakutora iwe.

Chii chinonzi Orlistat?

Orlistat, iyo inotengeswa semishonga yemishonga pasi pezita rekutengeserana Xenical, inonzi chiremba kushaya kurasikirwa kwemishonga yakagadzirirwa kutarisa nharo dzakashata dzakadai sekuwedzera kuneta, pamwe nezvimwe zvinhu zvine chokuita nekurema. Inogadzirwa neGlaxoSmithKline semuwandisi wezvinodhaka zvinonzi Alli muviri United States neUnited Kingdom.

Orlistat's generic formulations inowanika munyika dzinoverengeka. Kubva 2000, yakarongerwa seS3 kupfuura-the-counter mishonga muAustralia. Kugamuchirwa kwaOrlistat sechirwere chepamusoro-chinodhaka chaiva nharo inopesana muUnited States. Yakaramba ichirwisana pamusoro pekushanda nekuchengeteka kwekambani neboka rekutsigira vatengi raizivikanwa seChisidenti Citizen.

Orlistat zvaanoita se lipase inhibitor, iyo inowanzoreva kuti inodzivisa kudya kwemafuta kubva pakudya, nokudaro kuderedza kuwanda kwemakoriri amunotora. Kungofanana nemamwe akawanda kuora kurasikirwa nemishonga, Orlistat yakagadzirirwa kushandiswa pamwe chete nemamwe mararamiro ehupenyu sekuita muviri uye kudya. Zvidzidzo zvekuchipatara zvinoratidza kuti vanhu vanoomerera nechisungo ichi vanomira mukana wokurasikirwa maviri kana matatu kilogiramu kupfuura izvo zvisingasanganisi mishonga mukurasikirwa kwemauto avo.

Chimwe chezvinhu zvinodiwa pamusoro peOrlistat ndezvokuti hazvibatsiri kukura uremu asi zvinogadzirisawo kukonzera ropa. Uyezve, izvi zvinodhaka zvinodhaka zvinotendwa kuti zvinodzivisa kutanga kwechirwere cheshuga cheshuga kuvanhu vane uwandu hwakafanana nenzira iyo mararamiro ehupenyu anoita.

Nepo kune maverengero eOrlistat akawanda anofara pamusoro, panewo mamwe Orlistat nemigumisiro yekuteerera. Iyo inonyanya kutaurwa yechipfuva yehutachiwana hwepiritsi iyi yekurasikirwa kwepiritsi inotyisa. Ichi ndicho chirwere chepamuviri chinoratidzwa nemafuta, zvisikwa zvakasununguka. Zviratidzo, zvinonzwisisika, zvishoma nezvishoma.

Orlistat Mechanism yekuita

Orlistat isimba rakasimba Romase Lipase Inhibitor. Ichi chinodhaka chinonzi reversible active-site inhibitor yemakumbo emapases. Mishonga iyi inoumba chisungo chekovalent pamwe nesangano rinoshandiswa serine mupancreatic uye gastric lipases, nokudaro kudzivisa maitiro avo nekudzivirira mafuta kubva kune kudya kubva pakuva hydrolyzed uye kuiswa. (NCI04).

Mumashoko akareruka, Orlistat inobatsira kurasikirwa kwemazivi nekuderedza pasi pancreatic uye gastric lipases, iyo ndiyo inyanzvi inokonzera mumatumbo inoparadza triglycerides. Apo idzi lipases zvakadzivirirwa, iyo hydrolyzation ye triglycerides kubva pane kudya kwako kusvika mukunyanya kuneta mafuta acids inodziviswa.

Mapiritsi anodya anotorwa nemuromo uye kamwe akatorwa; local lipase inhibition inoitika mukati meGI tract. Chechi chiduku chiduku chechirwere chinopinda mumuviri, uye vazhinji vezvinodhaka vari kubviswa kuburikidza nemafuta.

Zvidzidzo zvenguva pfupi zvakawana Orlistat kuti ive yakasimba mukudzivisa inzyme inobatanidzwa mukuparadzirwa kwemasero epabonde ane ngozi. Kunyange zvakadaro, zvingava nemigumisiro yemishonga (yakadai sekudzivirira kweimwe masero asina kutarisirwa kana kusagadzikana kwebioavailability) inodzivisa kushandiswa kwayo senhengo inobatsira inopikisa. Mune imwe tsvakurudzo, vatsvakurudzi vakatora nzira yemakemikari yeproteomics kuti vawane zvinangwa zvemasero matsva zvechirwere, kusanganisira zvisiri izvo.

Pachirwere chechirwere chechirwere che 120 mg 3 kakawanda pazuva zuva risati rasvika, orlistat kuperesira mapiritsi inodzivirira pasi pe30 muzana yemafuta ane utano kubva pakupinda mumuviri. Kutora mishonga yakawanda hazvipi zvinowedzera kuipa.

ShandisaOrlistatpowder

Orlistat inoshandiswa semutoro wekutengesa uremu. Icho chisarudzo chakanakisisa kune vanhu vane kuwandisa kana kuoma. Iyi piritsi yekurasikirwa yakakosha inokurudzirwa kuti ishandiswe nevanhu vane zvinetso zvehutano zvine chokuita nekuremera. Inopikira kubatsira vanhu kwete kungorasikirwa nemutoro, asiwo kunobatsira kuvadzivisa kuti vasawanazve kuyerwa kwavakaita. Nokuita kudaro, zvinobatsira kuderedza dambudziko rekurwirwa kwepamusoro kweropa, chirwere cheshuga, chirwere chemwoyo, nezvimwe zviitiko zvakawanda zvehutano izvo zvinobatanidzwa nekuwedzerwa.

Muwandu wekurema kwekureruka mushure mekutora Orlistat kunosiyana kubva kune mumwe munhu kune mumwe. Vatsvakurudzi vanomhanya kuongororwa kwemakiriniki anosvika gore rimwe vakaona kuti pakati pe35.5 muzana uye 54.8 muzana yezvidzidzo zvakakwanisa kuwana 5 muzana inowedzera kuderera mumuviri wenyama, kunyange zvazvo kwete yose yakarasikirwa yakave yakawandisa. Pamusoro pe16.4% -24.8 yezvidzidzo zvakakwanisa kuzadzika zvishoma ne10 muzana inoderera mumafuta emuviri. Apo hurukuro idzi dzakarega kutora Orlistat, nhamba yakawanda yavo yakawana zvakare kusvika ku35 muzana yehuremu hwavakakwanisa kurasikirwa.

Nhamba yeOrlistat

Orlistat inouya nenzira ye-turquoise, yakaoma-gelatin capsules ine pellets yeupfu uye inoyera 120-mg. Iko rinorayirwa zuva rega rega ndiro matatu capsules pazuva. Iwe haufaniri kutora mapiritsi matatu pane imwe chete, asi panzvimbo iyoyo tora bheteti imwe neimwe yekudya kukuru iyo ine mafuta, kureva, imwe yezvokudya zvekudya, imwe yekudya kwemasikati, uye imwe yekudya kwemanheru. Iwe unogona kutora piritsi imwe nechikafu kana kusvika kweawa rimwe mushure mekudya. Kana kana kudya kuchiwanzosara, kana kana kudya kwako kusina mafuta, chirongwa cheOrlistat chinogona kubviswa. Maitiro ari pamusoro peanorayirwa zuva rega rega haana kuwanika kupa chero humwe rubatsiro.

Orlistat inonyanya kubudirira kana ichibatanidzwa nemamwe mano ekurasikirwa kwekureruka zvakadai sokunamatira kune kudya kunovaka muviri, kuderedzwa-koriori kudya uye kugara uchidzidzira. Iwe unorayirwa kuti utore piritsi yekurasikirwa nehokudya ine huwandu hunenge huwandu hwe30 muzana yekoriyori kubva kumafuta. Migumisiro yemishonga inowanikwa nokukurumidza apo 24-48 maawa mashure mushure mekutora chirwere.

Orlistat yakawanikwa ichibudirira mukuderedza kushandiswa kwemamwe mavitamini ane mafuta-soluble uye beta-carotene. Sezvo zvakadaro, vanhu vanotora mapiritsi vanokurudzirwa kuti vatore pamwe chete nemavhamhamini akawanda ane mavithamini ane mafuta anogadzikana kuti ave nechokwadi chokuti ane chikafu chakakwana. Zvinokurudzirwa kuti kuwedzera kwevhitamini kunotorwa maawa maviri mushure mokunge watora Orlistat.

Kana vari ivo vanotambira chirwere che cyclosporine, vanorayirwa kuti vatungamirire cyclosporine kwemaawa mashoma 3 mushure mokutora Orlistat. Kune avo vanogamuchira levothyroxine therapy, vanokurudzirwa kutungamirira levothyroxine therapy maawa mashoma 4 mushure mokutora Orlistat. Avo vanotora zvose Orlistat uye levothyroxine vanofanira kuongororwa zvakanyatsonaka nokuda kwekuchinja kwehutachiona basa.

OrlistatPrecautions

Pakupedzisira, orlistat yakanyatsotorwa pasi pemurairo wechiremba kana wemishonga. Zvisinei, muZ2007, US Food and Drug Administration yakabvumira kuti iwedzere kune-market-market, saka, ichiita kuti iwanike kune wese.

Chengetedza chero chero yeropa rekuita

Usati watora ichi chirwere, zvinonzwisisika kutaurira chiremba wako pamusoro pehupi hupi hwehutachiona hunoitika. Orlistat ine mishonga isingabatsiri, iyo inogona kunge isingafadzi iwe, zvichiita kuti uwedzere kugadziriswa kwemagetsi uye nemigumisiro. Mamwe acho anosanganisira cellulose, microcrystalline, gelatin, silica, uye sodium starch glycolate.

Funga nezvezvenyaya yezvokurapa

Iwe unofanirwa kugovana nemudzimai wako wemishonga kana chiremba pamusoro pemhando ipi zvayo yehutano iwe ungave uine. Izvi ndezvokuti orlistat inopesana nezvimwe zvinhu zvisina kunaka uye zvinetso, kunyanya izvo zvinosanganiswa nekudya.

Kana iwe uchitambura kune chero ipi zvayo pasi apa, zvinokurudzirwa kutsvaga mamwe mazwi kubva kune unyanzvi.

Malabsorption syndrome

Ichi chisingaoneki chinokonzera kukwana kusakwana kwezvokudya zvekudya pamwe neGIT system. Iwe unofanirwa kuona kuti orlistat pachayo inoshanda nekudzivisa kudyiwa kwemafuta. Hisquequequequequeque hisquequeque his hisquequeque his hisquequeque his hisquequequeque hisquequequequeque followingque produits his produitsque hisque following vers produits hisquequequequeque hisque hisque hisqueque hisqueque hisque followingque produitsquequequequeque produits hisque hisquequequequequequequeque his his his hisque his following produits produitsque his hisonn hisqueque his hisquequequeque hisquequeque his his produits produitsquequequeque hisque produitsqueque his hisque hisquequeque

Chirwere chechiropa kana cholestasis

Aya ndiwo mamiriro ezvinhu mune izvo zvinodzivirira kweye bile kuyerera kune chiropa. Kune akati wandei mishumo inobatanidza orlistat kune akakuvara chiropa kukuvara, kunyange ichiitika mune zvisingawanzoitika kana pasi yakakwira dosage

Gallbladder chirwere

Izvi zvinosanganisira cholecystectomy uye syndromes yakabatana.

Mamwe mararamiro aunofanira kuudza kumunhu wako wemishonga inosanganisira kutapurika kweHIV, chirwere chetachiona, mafungiro eminzwa, kugumburwa, kana kuputika. Pakunetseka kana kunetseka, orlistat inogona kuguma kusina kubatanidza kurapwa kweanopempile nekupindira nekudya.

Kudya zvinetso

Zvimwe zvezvinetso izvi zvinonzi bulimia uye anorexia. Uyezve, hapana chikonzero chekutora orlistat kana iwe usisiri kupisa simba.

Mamwe mishonga

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Kana uri pa cyclosporine, chiremba wako angangokuudza kuti urege orlistat. Zvisinei, iwe unogona kurongedza chete nemirayiridzo yakaoma. Kuti uve parutivi rwakachengeteka, unofanirwa kutora maawa maviri asati ava nemishonga yekugadzirisa uremu kana maawa maviri gare gare.

Uyezve, iwe unofanirwa kutaura mishonga yemishonga uye isiri mishonga, kudya kwezvokudya, mavitamini, anticoagulants, kana mishonga yemishonga iwe unogona kutora.

Vakadzi vane pamuviri uye vanoyamwisa

Iyi mishonga yekudzivirira kuyerwa haisi yevana vanotarisira, chero munhu anoronga kubata, kana kunwisa mums. Iyo mishonga haifaniri kunge iine kurasikirwa kwehutano uye ichaguma ichikuvadza fetus.

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Diabetics

Orlistat ndiyo iyo munhu wese ane chirwere cheshuga anoda kuvandudza nekudzivirira shuga yeropa nekuvandudza glucose kushivirira. Kunyange zvakadaro, iwe uchafanirwa kuongororwa nehuga huwandu uye nguva dzose unoshanyira chiremba. Queque hisqueque his hisquequequeque his his his hisquequequequequequequeque his hisque followingque hisque his hisque produits hisque hisque produits hisque following hisqueque followingque his following followingque followingqueque his his hisqueque followingque hisque hisque produitsqueque his followingque following produitsque following following following his produitsque followingquequequeque produitsque hisqueque his his produitsqueque hisque his hisque hisque hisque his followingque produits hisque hisquequequequeque hisqueque followingqueque followingque produitsquequeque

Orlistat Side Effects

Kungofanana nemishonga yakawanda, orlistat ine migumisiro yaro. Icho chinonyanya kukosha chikamu chinogara chichionekwa mumitemo yemhuka. Zvisinei, izvi zvinogona kuonekwa chete mumavhiki mashomanana ekutanga kutora kurasikirwa kwemishonga.

Kune vamwe vanhu, zviratidzo zvinogona kuderedza nguva kune vamwe; inogona kuramba ichiendesa kanalistat. Panguva ino, zvakachenjera kuudza chiremba wako. Kunyanya kutenderera iwe uri kune kudya kwemafuta-mafuta, zvinowanzove ndezvemigumisiro yekuderedza.

Heano mamwe maitiro akafanana;

Steatorrhea

Kunyange zvazvo kusina njodzi, steatorrhea ndiko kuvapo kwemafuta uye mafuta akawandisa muchitsiko. Kubvira kana orlistat inhibits lipases, hakuzovi nekugadziriswa kwemafuta emafuta. Somugumisiro, zvimedu zvichaonekwa seine mafuta uye zvinotyisa.

Kuti udzivise izvi, mumwe anofanirwa kudzivisa kudya zvakakosha mumakoriri uye mazinga akawanda-mafuta. Maererano nemitemo ye FDA, mari yacho inofanira kunge iri mukati ma0.53 ounces uye isingapfuuri 30%.

Flatulence

Muzviitiko zvakawanda, gasi inobuda kunze kwekubuda kwemafuta. Iwe unofanirwa kuongorora zvipfeko zvako kana zvepurasitiki nekuda kwekuona mafuta.

  • Fecal incontinence

Kusununguka, kukurumidzira, uye nguva dzose kutama kwemakumbo

  • Kusuruvara uye kurwadziwa mumimba
  • Kuenda kumwedzi kusina nguva
  • Nhamba yehuga yakadzika

Izvi zvakajairika pakati pevanhu vane chirwere cheshuga chechipiri II.

  • Kuora kwechiropa zvakanyanya

Mhosva dzakadai hadziwanzo asi dzingaitika kana uine zvimwe zvinonetsa chiropa, kana iwe ukatora dosage yakakwira. Muna 2010, FDA yaisanganisira yambiro yekuchengetedza pane orlistat mavara, ayo anoratidza njodzi yekukuvara kwechiropa.

Nekudaro, iyi mhedzisiro ichiri kupokana nekufunga kuti imwe nyaya yekudzidza yakabudiswa paBritish Medical Journal yakaratidza zvimwe.

Zvimwe zviratidzo zvinonyevera zvechirwere chechiropa zvinosanganisira kurutsa, kurwadziwa kwepamuviri, ganda rinopenya, uye urinhi.

Allergic reactions

Hazviwanzoitiki kuti uwane chero hypersensitivity kana kugadzirisa zvinokonzera kana uchitora orlistat kurasikirwa piritsi. Kune vamwe vanhu, zvisingabatsiri zvinoshandiswa mumushonga zvinogona kukonzera kushungurudzika, kubvarura, kuputika, kuputika kwemuviri, kufema kunetseka, kana chizuru.

Mamwe mhedzisiro asinganyanye kujairika anosanganisira kushushikana, kutemwa nemusoro, kubuda ropa, kusagadzikana rectal, kuneta, kushaya chikafu, uye gallstones. Kana iwe uchinge uchinge uchinge waona zviratidzo zvakanyanya, iwe unofanirwa kuzivisa chiremba wako nekukurumidza kana kuudza kune FDA Kubika Chirongwa.

Chirevo chekupedzisira paOridat powder

Kunyange zvazvo orlistat ine zvikamu zvishoma zvemigumisiro, iyo yakaisvonaka inorema kurasikirwa kurapwa iyo ichapa mhinduro mukati memavhiki maviri. Chakavanzika chokubatsirwa neizvi zvinodhaka zvinotevera mirayiridzo, kunzwisisa zvinodzivirira, nekuongorora nezvekudya kwako.

Sezvaunotora orlistat, zvakakosha kutevera chirongwa chakanaka chekudya, kudya mafuta mashoma, pasi makorikori, nekuita muviri nguva dzose. Kudya kwakakodzera kunofanira kusanganisira zvimwe zvibereko, miriwo, uye mbeu. Uyezve, unofanirwa kuwedzera kudya kwako nemishonga yakakosha yemiti yakakosha kubva ku-orlistat inodzivisa kudya kwemavhithamini ane mafuta.

Paunenge uchikahadzika, unogona kuonana nemudzimai wako wemishonga kana chiremba kuti uwane mamwe mirayiridzo. Zvimwewo, unogona kutaura neU.S. Food and Drug Administration kune chero mibvunzo kana kuudza hupenyu hwehupenyu hunotyisa, husina kunyorwa.


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KUGADZIRIRA UYE KUDZIDZA:

Ichi Chinyorwa Kutengeswa Kwekutsvagisa Chete Chete. Mitemo Yekutengesa Nyorera. Kwete Yekushandiswa Kwevanhu, kana Kurapa, Veterinary, kana Kushandisa Kweimba.


COA

COA 96829-58-2 Mamiriro Ezvinhu AASRAW

HNMR

Raw Orlistat powder (96829-58-2) hplc≥98% | AASraw Fat Kurasikirwa powder

KUNYANYA kunopa kuchena 99% Orlistat poda yakasvibirira kuti vashandise muviri kana kuti pasi pasi mabhii ekushandisa mumuromo.

Recipes

References & chigadzirwa mhizha

Orlistat Inoshanda Sei Seweya Wekurasikirwa Zvinodhaka?

Bibliographie

Zhi J, Melia AT, Eggers H, Joly R, Patel IH (1995). "Kudzokorora kwemaitiro mashoma ekugadzirwa kwe orlistat, lipase inhibitor, mune vanozvipira vane hutano". J Clinic Pharmacol. 35 (11): 1103-8

  1. Garcia SB, Barros LT, Turatti A, et al. Anorwisa-obesity agent Orlistat inobatanidzwa kuti iwedzere mukolonic preneoplastic markers mumakonzo anobatwa nekemikari checogenogen. Cancer Lett. 2006; 240: 221-4.
  2. FDA inobvumirana ne (orlistat 60 mg capsules) Over-The-Counter "(PDF) (Press release). PRNewswire. 7 February 2007
  3. Mittendorfer B, Ostlund RE, Jr, Patterson BW, et al. Orlistat inhibisa cholesterol yekudya inodyiwa. Obes Res. 2001; 9: 599-604
  4. Peng-Yu, Yang; Kai, Liu; Mun Hong, Ngai; J.Lear, Martin; R.Wenk, Markus; S.Qin, Yao (2010). "Basa-rakagadzirwa neproteome kufungidzirwa kwezvinangwa zvemasero eOrlistat-an FDA-inogamuchirwa nemishonga inorambidza tumarara". Nyaya yeAmerican Chemical Society. 132 (2): 656-66.