Pregabalin powder

Pregabalin Powder Vhidhiyo-AAsraw

Raw Pregabalin Powder Basic Characters

Chii chinonzi Pregabalin Powder?

Pregabalin powder mushonga wekirasi ye gabapentinoids, iyo inoshanda nekuvhara dzimwe nzira dze calcium. Inosungira kune α2δ subunit yemamwe voltage-gated calcium channels (VDCCs) mukati mehutano hwehutano uye inoita sevhavha yeVDCCs ine α2δ subunits. Kunyange zvazvo iri gamma-aminobutyric acid (GABA) analog, haisungiri kuGABA receptors, uye haishanduki kuGABA kana imwe GABA receptor agonist in vivo kana kuti inoronga zvakananga GABA kutakura kana metabolism.

Chii chinonzi Mechanism yePregabalin Powder

Iyo nzira yekuita pregabalin haina kunyatsonzwisiswa, asi inotendwa kuti inoderedza kuburitswa kwakasiyana-siyana-inotenderera neurotransmitters kuburikidza nekudzivisa basa re calcium channels, nokudaro kuderedza zviratidzo, nokuti pregabalin inogona kusunga nehupamhi hwepamusoro kune α2δ domain, iyo. ndiyo chikamu chekubatsira che calcium-gated channel mumasero emagetsi epakati.Migumisiro yezvidzidzo zvakashandurwa zvembeva uye kuedza nemakemikari ane maitiro akafanana ne pregabalin yakaratidza kuti pregabalin inosunga kune α2-δ nzvimbo uye inogona kudzivisa marwadzo uye kubatwa mumhando dzemhuka dzine pregabalin. . In vitro ongororo dzakaratidza kuti pregabalin inogona kuderedza kuburitswa kwakasiyana-siyana-inotenderera neurotransmitters kuburikidza nekudzivisa basa re calcium channels, nokudaro kurapa uye kuderedza zviratidzo.

Ndezvipi Zvakanakira Pregabalin Powder?

Zvakanakira pregabalin poda inosanganisira:

①Neuropathic Pain Suppression

Pregabalin yakanyorwa semushonga wekutanga wekurapa chirwere cheshuga neuropathy, inotarirwa postherpetic neuralgia, uye central neuropathic pain. Zvidzidzo zvakaratidza kuti madosi epamusoro e pregabalin akabatana nekubudirira kukuru. Kunyange zvazvo kushandiswa kwe pregabalin kune kenza-yakabatana neuropathic kurwadziwa kune nharo, inowanzoshandiswa. Uyezve, yakaongororwa nokuda kwekudzivirira kurwadziwa kwepashure-kuvhiya.

② Anti-Convulsant

Pregabalin inonzi gamma-aminobutyric acid (GABA) analogue ine chimiro chakafanana uye chiito kune gabapentin uye antiepileptic chiitiko. Kunyangwe iyo antiepileptic mashandiro epregabalin isingazivikanwe, zvidzidzo zvemurabhoritari zvakaratidza kuti pregabalin ine anticonvulsant chiitiko mumhando dzakasiyana dzepfari. Kunyange zvazvo kuwanda kwekuita mumhando dzemhuka kwakafanana neiyo gabapentin, pregabalin inopfuura 3-10 nguva yakawanda kupfuura gabapentin.

③Kunyaradza Kuzvidya Mwoyo

Pregabalin inokurudzirwa seimwe yemishonga mikuru yakawanda yekurerutsa kusagadzikana. Inoshanda zvine mwero uye yakachengeteka pakurapa kwe generalized kusagadzikana kusagadzikana. Inoshandawo mukurapa kwenguva pfupi uye kwenguva refu kwehutano hwemagariro evanhu uye mukuderedza kuzvidya mwoyo vasati vavhiyiwa.

④ Zvimwe Zvishandiso

lPregabalin dzimwe nguva inonyorerwa vanhu vane bipolar disorder.
lZvidzidzo zvakaratidza kuti pregabalin inogona kunyatso kurapa migraine.

Chii mhedzisiro yePregabalin Powder

Migumisiro yepregabalin yakafanana neyeimwe central central nervous system depressants. Maitiro asina kunaka ezvinodhaka ane chekuita nekushandiswa kwe pregabalin anosanganisira:

• Zvakanyanya kuitika (> 10%): dzungu, somnolence.
• Zvakajairwa (1-10%): Chiono chisina kujeka, diplopia, kuwedzera kudya uye kuwedzera uremu, kufara, kuvhiringidzika, nezvimwe.
• Zvisingawanzo (0.1-1%): hypoglycemia, rash, tsandanyama cramps, myalgia, arthralgia, thrombocytopenia, matombo eitsvo, nezvimwewo.
• Kashoma (<0.1%): neutropenia, hypotension, hypertension, pancreatitis, oliguria, rhabdomyolysis, pfungwa dzekuzviuraya kana maitiro.

Nzira yekutora pregabalin poda

• Time:Tora pregabalin poda ine kana isina chikafu panguva imwe chete zuva rega rega. Pregabalin inoda kutorwa nguva dzose, kwete chete apo kurwadziwa kwetsinga kunowedzera.
• Deredza kana kudzivirira doro paunenge uchitora pregabalin:Kutora pregabalin nedoro kunogona kuita kuti vanhu vawedzere kurara, kuneta, kana dzungu, uye kuwedzera njodzi yako yekudonha.
• Doro rakapotsa:Kana ukakanganwa kuitora, tora pakarepo zuva rinotevera. Asi kana yave kuda nguva yedosi rinotevera (mumaawa mana), tora dosi rinotevera panguva chaiyo. Usatora kaviri dose.
• Kubvisa marwadzo hakusi pakarepo: Tora pregabalin yekurwadziwa, haibvise marwadzo nekukurumidza. Zvinogona kutora mazuva mashoma kuti marwadzo ambopera.
• Misa pregabalin zvishoma nezvishoma: Kana uchifunga kuti pregabalin isiri kushanda, usarega kuitora kamwe kamwe nekuti kumisa kurapwa kamwe kamwe kunogona kukonzera mhedzisiro. Zvinowanzoita zvakanaka kumisa pregabalin zvishoma nezvishoma.

Nzira yekuwana sei chaiyo Pregabalin Powder mutengesi pamhepo?

Vazhinji vatengesi vanopa pregabalin poda zvese pamhepo uye muzvitoro zvenyama pasi rese, asi zvakakosha kuti ungwarire paunenge uchitenga kuti uve nechokwadi chekuti unowana chigadzirwa chemhando yepamusoro chinopa mhedzisiro yakanaka. Havasi vese vatengesi vanoti vanotengesa pure pregabalin poda ndeyechokwadi, sevamwe vanofarira chete kuita mari uye kwete mhedzisiro yaunowana kubva kumushonga. Zvinokurudzirwa kuita tsvakiridzo yakakwana usati watenga chero, kusanganisira kuongorora wongororo yevatengi uye ratings yekambani kuti unzwisise mashandiro emutengesi zvizere.

Kambani yedu, aasraw, ndiyo inotungamira pregabalin poda mutengesi uye mugadziri munzvimbo iyi, ine mushandisi-inoshamwaridzika webhusaiti iyo inokutendera iwe kuisa maodha zviri nyore uchishandisa chero mudziyo. Isu tinoedza kuendesa zvigadzirwa zvedu nekukasira, uye iwe unogona kutenga hupfu muhuwandu kana huwandu hunoenderana nezvido zvebhizinesi rako. Nekudaro, zvakakosha kuti uzive kuti haufanirwe kutanga kutora pregabalin pasina kutungamira kwenyanzvi yekurapa, zvisinei nekuti unogona kuitenga zviri nyore sei.

HNMR

Chii chinonzi HNMR uye HNMR spectrum inokuudza chii? H Nuclear Magnetic Resonance (NMR) spectroscopy inzira yekuongorora chemistry inoshandiswa mukudzora kwemhando uye tsvagiridzo yekuona zvirimo uye kuchena kwesample pamwe nemaitiro ayo mamorekuru. Semuyenzaniso, NMR inokwanisa kuongorora musanganiswa ane zvinozivikanwa makomboni. Kumakomisheni asingazivikanwe, NMR inogona kushandiswa kuenzanisa nekuona maraibhurari kana kufembera iyo yakakosha chimiro zvakananga. Kana iyo yekutanga dhizaini yazivikanwa, NMR inogona kushandiswa kuona mamorekuru conformation mumhinduro pamwe nekudzidza zvimiro zvemuviri padanho remamorekuru senge conformational exchange, shanduko yechikamu, solubility, uye diffusion.

Pregabalin Powder( 148553-50-8)-COA

Pregabalin Powder( 148553-50-8)-COA

Nzira yekutenga Pregabalin Powder kubva kuAASraw?

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Reference

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[2] Calandre EP, Rico-Villademoros F, Slim M (Mbudzi 2016). "Alpha2delta ligands, gabapentin, pregabalin uye mirogabalin: kuongorora kwekliniki yavo yemishonga uye kushandiswa kwekurapa". Nyanzvi Ongororo yeNeurotherapeutics. 16 (11): 1263–1277.

[3] Finnerup NB, Sindrup SH, Jensen TS (Gunyana 2010). "Uchapupu hwekurapa kwemishonga yekurwadziwa kweuropathic". Marwadzo. 150 (3): 573–581.

[4] Clarke H, Bonin RP, Orser BA, Englesakis M, Wijeysundera DN, Katz J (Nyamavhuvhu 2012). "Kudzivirirwa kwemarwadzo asingagumi epashure uchishandisa gabapentin uye pregabalin: kusanganiswa kwakarongeka kuongororwa uye meta-analysis". Anesthesia uye Analgesia.

[5] Bandelow B, Wedekind D, Leon T (Chikunguru 2007). "Pregabalin yekurapa kwehuwandu hwekushushikana kusagadzikana: inoveli pharmacologic kupindira". Nyanzvi Ongororo yeNeurotherapeutics. 7 (7): 769–781.

[6] Calandre EP, Garcia-Leiva JM, Rico-Villademoros F, Vilchez JS, Rodriguez-Lopez CM. Pregabalin mukurapa kwekusingaperi migraine: yakavhurika-label kudzidza. Clin Neuropharmacol. 2010 Jan-Feb;33(1):35-9.

[7] Millar J, Sadasivan S, Weatherup N, Lutton S (Gunyana 7, 2013). "Lyrica Nights-Recreational Pregabalin Abuse muUrban Emergency department". Emergency Medicine Journal. 30 (10): 874.2–874.

[8] Tanyıldız B, Kandemir B, Mangan MS, Tangılntız A, Göktaş E, Şimşek S (Gumiguru 2018). "Bilateral Serous Macular Detachment Mushure meKuedza Kuzviuraya nePregabalin". Turkish Journal yeOphthalmology. 48.

[9] Desai A, Kherallah Y, Szabo C, Marawar R (Kurume 2019). "Gabapentin kana pregabalin induced myoclonus: Nyaya yenyaya uye kuongorora mabhuku". Nyaya yeClinical Neuroscience. 61:225–234.

[10] Stahl SM, Porreca F, Taylor CP, Cheung R, Thorpe AJ, Clair A (Chikumi 2013). "Zviito zvakasiyana-siyana zvekurapa zve pregabalin: inzira imwe chete inokonzera mabasa akawanda emishonga?". Maitiro muPharmacological Sayenzi. 34 (6): 332–339.

[11]Ndeapi mahomoni anowanzo shandiswa kudzoreredza bonde rehove (Chiremera)

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