Regorafenib powder (755037-03-7) - Mugadziri Fekitori Mutengesi
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Regorafenib

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Regorafenib powder ndeyemuromo yakawanda-kinase inhibitor iyo inotarisa angiogenic, stromal uye oncogenic receptor tyrosine kinase (RTK). Regorafenib powder inoratidza anti-angiogenic chiitiko nekuda kwayo mbiri yakatarisana VEGFR2-TIE2 tyrosine kinase inhibition.

Product Description

Basic Hunhu

Product Name Regorafenib upfu
CAS Number 755037-03-7
Molecular Formula C21H15ClF4N4O3
Formula Weight 482.8
Synonyms Regorafenib upfu;

755037-03-7;

BAY 73-4506;

Stivarga;

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide.

Kuonekwa Yakachena kune off-chena poda
Kuchengeta uye Kubata Chengetedza pakushambidzika kwemukati, gara munzvimbo inotonhorera, yakaoma, kure nezuva.

 

Regorafenib Powder Tsananguro

Regorafenib powder ndeyemuromo yakawanda-kinase inhibitor iyo inotarisa angiogenic, stromal uye oncogenic receptor tyrosine kinase (RTK). Regorafenib powder inoratidza anti-angiogenic chiitiko nekuda kwayo mbiri yakatarisana VEGFR2-TIE2 tyrosine kinase inhibition. Kubva gore ra2009 yakadzidzwa senge ingangoita yekurapa sarudzo mumhando dzakasiyana dzemota.Paka gore ra2015 yaive iine mvumo mbiri dzeUS kumatenda epamberi.

Regorafenib powder ndeye yakanangwa kurapa iyo inosunga uye inosunga kune tyrosine kinase receptors uye inhibits epidermal kukura factor receptor (EGFR) uye vascular endothelial kukura chinhu (VEGF), zvinogamuchirwa pamusoro pechitokisi. Nekusunga kune aya anogamuchira regorafenib powder anovharira nzira yakakosha inosimudzira kupatsanurwa kwesero.

 

Regorafenib Powder Maitiro Ekuita

Regorafenib powder idiki mamorekuru inhibitor yeakawanda membrane-yakasungwa uye intracellular kinases inobatanidzwa mune zvakajairika maseru mashandiro uye mune pathologic maitiro senge oncogenesis, tumor angiogenesis, uye kugadziriswa kweiyo tumor microenvelo. Mune in vitro biochemical kana maseru ekuyedza, regorafenib poda kana ayo makuru evanhu anoshanda metabolites M-2 uye M-5 akatadzisa chiitiko cheRET, VEGFR1, VEGFR2, VEGFR3, KIT, PDGFR-alpha, PDGFR-beta, FGFR1, FGFR2, TIE2 , DDR2, TrkA, Eph2A, RAF-1, BRAF, BRAFV600E, SAPK2, PTK5, uye Abl pazvikamu zve regorafenib powder zvakawanikwa mukiriniki. Mune in vivo modhi, regorafenib poda yakaratidza anti-angiogenic chiitiko mune gonzo bundu modhi, uye kuvharidzira kwekukura kwechirwere pamwe neanti-metastatic chiitiko mune akati wandei mbeva xenograft modhi kusanganisira zvimwe zvevanhu colorectal carcinoma.

 

Regorafenib Powder Chikumbiro

Regorafenib powder ndeye yakanangwa kenza mushonga. Unogona kuve nayo sekurapa kwe:

▪ Gastro intestinal stromal cancer (GIST) - mhando isingawanzo nyoro yetissue sarcoma yemudumbu kana ura;

▪ Gomarara repamberi rakatanga muchiropa (gomarara rekutanga reropa).

 

Regorafenib Powder Side Mhedzisiro & Yambiro

Hatina kunyora zvese mhedzisiro. Hazvigoneki kuti iwe uwane zvese izvi mhedzisiro, asi iwe unogona kunge uine mamwe acho panguva imwe chete.

Inguvai uye sei yakakomba mhedzisiro yacho inogona kusiyana kubva pamunhu kuenda kumunhu. Ivo zvakare vanovimba neapi mamwe marapirwo auri kuva nawo. Semuenzaniso, yako mhedzisiro mhedzisiro inogona kuve yakaipa kana iwe zvakare uine mamwe madhiragi kana radiotherapy.

 

Zvinowanzovhiringidza

▪ Kuwedzera njodzi yekuwana hutachiona

▪ Kufema uye kutarisika kuchena

▪ Kurova, kubuda ropa mazino kana kubuda ropa mumhino

▪ Kuneta uye kushaya simba (kuneta)

▪ Kurwadza, kutsvuka uye kupenya pamichindwe nepasi petsoka

▪ Kupera kudya uye kurasikirwa nemuviri

▪ Manyoka

▪ Inzwi rinochinja

▪ Inzwi rinochinja

▪ Maronda emumuromo uye maronda

▪ Ganda rinochinja

▪ Kunzwa kana kurwara

▪ Huwandu hwepamusoro hwebilirubin

▪ Kupisa zvakanyanya (fever)

 

Reference

[1] "Bayer Inosheedzera Nyowani Dhata paOncology Portfolio Ichaunzwa kuECCO-ESMO Congress 2009". Yakadzorerwa 2009-09-19.

[2] "Cancer fund dzosera mushonga mumwe chete, Regorafenib powder". BBC. 22 Chivabvu 2015. Yakadzorerwa 7 Chikumi 2015.

[3] FDA Yakagamuchirwa Zvinodhaka Zvigadzirwa: STIVARGA (regorafenib powder) mahwendefa emuromo

[4] Kim J, Ulu A, Wan D, Yang J, Hammock BD, Weiss RH (Chivabvu 2016). "Kuwedzerwa kweDHA Synergistically Kunowedzera Kubudirira kweRegorafenib powder yeItsvo Cancer Therapy". Molecular Kenza Therapeutics. 15 (5): 890-8.

[5] Hotta K, Ueyama J, Tatsumi Y, Tsukiyama I, Sugiura Y, Saito H, Matsuura K, Hasegawa T: Kushaikwa kweMupiro weMultidrug Resistance-inosanganisirwa Protein uye Organic Anion-inotakura Polypeptide kuenda kuPharmacokinetics yeRegorafenib powder, Novel Multi-Kinase Inhibitor, mumakonzo. Anticancer Res. 2015 Sep; 35 (9): 4681-9.