TAK-438 powder (1260141-27-2) poda - Mugadziri weFekitori Mutengesi
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TAK-438

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TAK438, inozivikanwawo seVonoprazan Fumarate, mushonga mutsva wekurapa zvirwere zvine chekuita neasidhi ine nzira yechiito yekuita inonzi potasium-inokwikwidza acid blockers (P-CABs) iyo inokwikwidza inodzivirira kusunga kwe potassium ions kuH +, K + -ATPase ( inozivikanwawo seprotoni pombi) mune yekupedzisira nhanho yegastric acid secretion mune gastric parietal maseru, inodzora gastric acid secretion Inopa yakasimba uye yakasimba asidi kudzivirirwa kwekudzivirira hutachiona.

Product Description

Basic Hunhu

Product Name TAK-438 upfu
CAS Number 1260141-27-2
Molecular Formula C21H20FN3O6S
Formula Weight 461.46
Synonyms Vonoprazan Fumarate;
TAK-438 upfu;
1260141-27-2;
Vonoprazan fumurate;
TAK438.
Kuonekwa Muchena kusvika pachena-poda yakachena
Kuchengeta uye Kubata Kuoma, kusviba uye pa0 - 4 C kwenguva pfupi (mazuva kusvika kumavhiki) kana -20 C kwenguva refu (mwedzi kusvika makore).

 

TAK-438 poda Tsanangudzo

TAK438, inozivikanwawo seVonoprazan Fumarate, mushonga mutsva wekurapa zvirwere zvine chekuita neasidhi ine nzira yechiito yekuita inonzi potasium-inokwikwidza acid blockers (P-CABs) iyo inokwikwidza inodzivirira kusunga kwe potassium ions kuH +, K + -ATPase ( inozivikanwawo seprotoni pombi) mune yekupedzisira nhanho yegastric acid secretion mune gastric parietal maseru, inodzora gastric acid secretion Inopa yakasimba uye yakasimba asidi kudzivirirwa kwekudzivirira hutachiona.

Mune akakwenenzvera gastric gland, TAK-438 poda kurapwa kwakakonzeresa murefu uye akasimba acid kugadzirwa kwekudzivirira Iyo yekudzivirira mhedzisiro yeTAK-438 poda paacid secretion yaiita kunge inosanganisirwa negastric parietal cell physiology.

 

TAK-438 upfu Mechanism of Action

TAK-438 powder (Vonoprazan fumarate) inogadzirwa ne pyrole uye potassium-inokwikwidza acid blocker (P-CAB) inokwikwidza inovhara saiti-inosunga nzvimbo yegastric H (+), K (+) - ATPase, enzyme yakakosha mu maitiro e gastric acid secretion. Iyo mukomboni inogona kuunganidzwa munzvimbo dzeacid uye inofanirwa kupa kwenguva yakareba yekudzivirira nekuda kwealkal pKa ye9.06.

Mune akakwenenzvera gastric gland, TAK-438 poda kurapwa kwakakonzeresa murefu uye akasimba acid kugadzirwa kwekudzivirira Iyo yekudzivirira mhedzisiro yeTAK-438 poda paacid secretion yaiita kunge inosanganisirwa negastric parietal cell physiology.

 

TAK-438 powder Kushanda

TAK-438 powder (Vonoprazan fumarate kana Vonoprazan) mushonga mutsva wekurapa zvirwere zvine chekuita neasidhi ine nzira yekuita inonzi potasiamu-inokwikwidza acid blockers (P-CABs) inokwikwidza inodzivirira kusunga kwe potassium ions kuna H +, K + - ATPase (inozivikanwawo seprotoni pombi) mune yekupedzisira nhanho yegastric acid secretion mune gastric parietal maseru. Mushonga unobvumidzwa muJapan kurapwa kwezvirwere zvine chekuita neacid, kusanganisira gastric ulcer, duodenal ulcer, Reflux esophagitis uye Adjunct kuna Helicobacter pylori eradication mune kesi yaHelicobacter pylori gastritis.

 

TAK-438 poda Side Mhedzisiro & Yambiro

Mhedzisiro mhedzisiro inosanganisirwa:

▪ manyoka,

▪ kusvotwa uye kurutsa,

▪ kupatirwa

▪ kurwadziwa nemudumbu,

▪ kuputika kweganda,

▪ chirungurira.

 

Izvi hazvisi zvese zvinokanganisa mhedzisiro yeTAK438. Kuti uwane rumwe ruzivo, bvunza chiremba wako kana wemishonga. Dana chiremba wako kuti akupe mazano ekurapa nezvemigumisiro. Unogona kuzivisa mhedzisiro kuDAA pa1-800-FDA-1088.

 

Reference

[1] Arikawa Y, Nishida H, Kurasawa O, Hasuoka A, Hirase K, Inatomi N, Hori Y, Matsukawa J, Imanishi A, Kondo M, Tarui N, Hamada T, Takagi T, Takeuchi T, Kajino M. Kuwanikwa kwe inobvisa pyrrole inotorwa 1- [5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e fumarate (TAK-438 powder) se potassium-inokwikwidza asidhi inodzivirira (P-CAB). J Med Chem. 2012 Chivabvu 10; 55 (9): 4446-56. doi: 10.1021 / jm300318t. Epub 2012 Kubvumbi 30. PubMed PMID: 22512618.

[2] Kondo M, Kawamoto M, Hasuoka A, Kajino M, Inatomi N, Tarui N. High-throughput kuongorora kwe potasium-inokwikwidza acid blockers. J Biomol Screen. 2012 Kukadzi; 17 (2): 177-82. doi: 10.1177 / 1087057111421004. Epub 2011 Sep 22. PubMed PMID: 21940711.

[3] Shin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O, Sachs G. Kufananidzwa kwenoverengeka potassium-inokwikwidza acid blocker yemudumbu H, K-ATPase, 1- [5- (2- fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 powder). J Chemishonga Exp Ther. 2011 Mbudzi; 339 (2): 412-20. doi: 10.1124 / jpet.111.185314. Epub 2011 Aug 9. PubMed PMID: 21828261; PubMed Central PMCID: PMC3199995.

[4] Hori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M, Inatomi N. Chidzidzo chichienzanisa antisecretory mhedzisiro yeTAK-438 powder, inoverengeka potassium-inokwikwidza acid blocker, ine lansoprazole mumhuka. J Chemishonga Exp Ther. 2011 Jun; 337 (3): 797-804. doi: 10.1124 / jpet.111.179556. Epub 2011 Mar 16. PubMed PMID: 21411494.

[5] Matsukawa J, Hori Y, Nishida H, Kajino M, Inatomi N. Chidzidzo chekufananidza pamusoro pemaitiro ekuita kweTAK-438 poda, inoverengeka potassium-inokwikwidza acid blocker, uye lansoprazole mumatunhu akakura etsuro tsinga dzemudumbu. Biochem Pharmacol. 2011 Chivabvu 1; 81 (9): 1145-51. doi: 10.1016 / j.bcp.2011.02.009. Epub 2011 Mar 1. PubMed PMID: 21371447.

[6] Hori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M, Inatomi N. 1- [5- (2-Fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 powder), inoverengeka uye ine simba potassium-inokwikwidza acid blocker yekurapa zvirwere zvine hukama neacid. J Chemishonga Exp Ther. 2010 Gumiguru; 335 (1): 231-8. doi: 10.1124 / jpet.110.170274. Epub 2010 Jul 12. PubMed PMID: 20624992.