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Ibrutinib

  1. Zvinotarisirwa Zvinodhaka Ibrutinib (CAS: 936563-96-1)
  2. Ibrutinib Maitiro Ekuita
  3. Izvo Ibrutinib Inoshandiswa Kwairi
  4. Ibrutinib Makomborero / Mhedzisiro
  5. Tinofanira Sei Kutora Ibrutinib
  6. Ibrutinib Side Migumisiro
  7. Ibrutinib Kuchengetedza

Zvinotarisirwa Zvinodhaka Ibrutinib(CAS: 936563-96-1)

Mishonga yakawanda mitsva ye lymphoma inotarisirwa zvinodhaka. Zvinotarisirwa zvinodhaka Chinangwa chekuuraya mhando yesero iyo yakashandura kenza kana kumira zviratidzo zvinoita gomarara maseru kukura kana kupatsanuka. Mu lymphoma, mhando yesero inova cancer inogona kunzi "lymphocyte" (rudzi rweye chena ropa reropa rinorwisa hutachiona). Kune akatiwandei marudzi e lymphocyte anogona kuve cancer. Ibrutinib inotarisa B lymphocytes (B masero) uye saka inoshandiswa kurapa B-cell lymphomas.

Masero anotumira uye anogamuchira zviratidzo kune mamwe masero. Zvimwe zvezviratidzo izvi zvinoita kuti masero arambe ari mapenyu uye ovaita kuti vaparadzane. Kune dzakawanda nzira dzekuratidzira nzira uye zviratidzo zvinotumirwa pamwe chete kana imwe yeidzi nzira. Ibrutinib isero rechiratidzo blocker rinotarisa puroteni inonzi 'Bruton' s tyrosine kinase '(BTK). BTK chikamu chemugwagwa unobatsira masero eB kuti arambe ari mupenyu uye achipatsanuka. Kuvhara BTK kunogona kuita kuti masero eB afe kana kuvadzivirira kukamura. Mushonga uyu saka unogona kumisa kupararira kwecancer cancer maseru.

 

Ibrutinib Mechanism of Action

Ibrutinib (936563-96-1) hachisi mushonga wemakemikari asi chimwe chezvinonzi “nzira dzokurapa.” Targeted Therapis ndiyo mhedzisiro yemakore ekutsvaga yakapihwa kunzwisisa mutsauko uripo pakati pemasero ekenza nemasero akajairwa. Parizvino, kurapwa kwegomarara kwakanangana nekuuraya nekukurumidza kunokamura masero nekuti chimwe chikamu checancer maseru ndechekuti dzinopatsanuka nekukurumidza. Nehurombo, mamwe emasero edu akajairika anopatsanuka nekukasira zvekare, zvichikonzeresa mhedzisiro.

Targeted therapy ndeyekutsanangura zvimwe zvikamu zvekenza masero. Masayendisiti anotarisa kusiyana kwakasiyana mumasero emukenza uye masero anowanzoitika. Idzi ruzivo runoshandiswa kugadzira chirongwa chinotarisirwa kurwisa makero ekenza pasina kutyisa masero ezvisikwa, izvo zvinotungamirira kune zvishoma migumisiro yechirwere. Mhando ipi neipi yekurapa inoratidzika inoshanda zvishoma zvakasiyana asi zvose zvinopesana nekwanisi yekenza yerineni kukura, kugovana, kugadzirisa uye / kana kutaurirana nemamwe masero.

Ibrutinib inhibits basa reBruton's tyrosine kinase (BTK). BTK chinhu chakakosha kuratidza mamorekuru eB-cell receptor siginicha yakaoma iyo inoita basa rakakosha mukupona kwemasero B akaipa. Ibrutinib inovhara masekondi anomutsa maseru B kuti akure uye apatsanurwe asingadzoreke. Tsvagiridzo inoenderera ichitsvaga kuti ndedzipi kenza dzinogona kunyatso kurapwa nemishonga yakanangwa uye kuona zvimwe zvinangwa zvemamwe marudzi ekenza.

Ongorora: Tinokukurudzira zvikuru kuti utaure nachiremba wako nezvehutano hwako uye marapirwo. Ruzivo rwuri mune ino webhusaiti rwunofanirwa kubatsira uye kudzidzisa, asi harwitsire zano rekurapa.

MUTSVENE ndiye mugadziri wehunyanzvi weIbrutinib.

Ndokumbirawo ubaye pano kuti uwane ruzivo pasinaCont Cont us

 

Izvo Ibrutinib Inoshandiswa Kwairi

❶ Kurapa vanhu vane mantle cell lymphoma (MCL; gomarara rinokurumidza kukura iro rinotanga mumasero ezvirwere zvemuviri) avo vakatorapwa nechero imwe chemotherapy mishonga.

❷ Kubata vanhu ne chisingaperi lymphocytic leukemia (CLL; mhando yekenza inotanga mumasero machena eropa) uye diki lymphocytic lymphoma (SLL; mhando yekenza inotanga kunyanya mune node node).

❸ Kurapa vanhu vane Waldenstrom's macroglobulinemia (WM; kenza inononoka kukura inotanga mune mamwe maseru machena eropa mumapfupa ako).

❹ Kurapa vanhu vane marginal zone lymphoma (MZL; kenza inononoka kukura iyo inotanga mune imwe mhando yemasero machena eropa ayo anowanzo kurwisa hutachiona) avo vakatorapwa neimwe mhando yemakemikari ekurapa.

❺ Kurapa vanhu vane chirwere chisingaperi chekubatirira chirwere (cGVHD; chinetso chehematopoietic stem-cell transplant [HSCT; maitiro anotsiva mwongo wemapfupa ane chirwere nemwongo une hutano] anogona kutanga chinguva mushure mekuisirwa uye agare kwenguva yakareba ) mushure mekurapwa zvisina kubudirira ne1 kana yakawanda mishonga.

Ibrutinib iri mukirasi yemishonga inonzi kinase inhibitors. Inoshanda nekudzivirira chiito cheprotein isina kujairika iyo inoratidza masero ekenza kuti iwande. Izvi zvinobatsira kumisa kupararira kwemasero ekenza.

Ibrutinib

Ibrutinib Benefits/ Mhedzisiro

Ibrutinib inofungidzirwa nenyanzvi dzakawanda kuti ive 'kurapa kwekurapa' kune mamwe marudzi e lymphoma. Inopa yakakwira mhinduro mitengo ichienzaniswa nemamwe marapirwo emhando dzakafanana dze lymphoma. Miedzo mikuru yakatungamira mukubvumidzwa kweibrutinib inotsanangurwa muchidimbu pazasi.

 

(1) Makomborero mune jasi cell lymphoma

Mantle cell lymphoma yakadzokazve kana kusapindura kune yekutanga-tambo kurapwa kunogona kunetsa kurapa. Zvisinei, chidzidzo chikuru munzvimbo ino chakaratidza kuti vanopfuura zvikamu zviviri kubva muzvitatu zvevanhu 111 vaibatwa nebrutinib vakapindura kurapwa (yavo lymphoma yakadzikira kana yakanyangarika).

Chidzidzo chechipiri muvanhu mazana maviri nemakumi masere vakafananidza ibrutinib nemumwe mushonga wekenza, temsirolimus, mune vanhu vakadzokazve kana kusagadzikana mantle cell lymphoma. Vanhu vairarama paavhareji yemwedzi gumi nemashanu pasina yavo lymphoma ichiwedzera kuipa kana ichirapwa nebrutinib kana ichienzaniswa neavhareji yemwedzi mitanhatu painorapwa ne temsirolimus.

 

(2) Makomborero mune chisingaperi lymphocytic leukemia (CLL)

Mhinduro dzisingagumi dzakaonekwa muvanhu vane CLL inorapwa neibrutinib. Mukuyedza kukuru kunosanganisira vanhu makumi matatu nevapfumbamwe vane CLL yakadzokororwa kana yekudzora, ibrutinib yakafananidzwa ne ofatumumab, iyo inowanzo shandiswa kuvanhu vane CLL yakadzoka. Gore rimwe mushure mekutanga kurapwa, kwakatenderedza makumi matanhatu neshanu muvanhu zana vaitora ibrutinib vaive neCLL iyo yaigara iri pasi pekutonga (izvi zvinonzi 'kufambira mberi-kusununguka kwekupona') zvichienzaniswa nevanhu vangangosvika matanhatu pavanhu zana vakabatwa ne ofatumumab.

Muchidzidzo chechipiri chaisanganisira vanhu makumi maviri nevatanhatu vaive vasati vagamuchira kurapwa kweCLL yavo, ibrutinib yaifananidzwa nekemotherapy drug chlorambucil. Mushure memazana mashanu emakore ekurapwa, vangangoita makumi mapfumbamwe nemakumi mashanu vanhu vaitora ibrutinib vaive neCLL iyo yaigara iri pasi pekutonga kana ichienzaniswa nevanhu makumi mashanu nevaviri muvanhu zana vakabatwa neklorambucil.

Kuwedzera ibrutinib kune bendamustine uye rituximab kune vanhu vakadzokerazve kana kusagadzikana CLL yaive zvakare inoshanda muchidzidzo chinosanganisira 578 vanhu. Ngozi yekufambira mberi kweCLL yakaderedzwa nekutora ibrutinib panzvimbo ye placebo (dummy kurapwa).

 

(3) Zvakanakira muWaldenström' s macroglobulinaemia (WM)

Chiyero chepamusoro chekupindura chakaonekwawo muvanhu vane WM - vangangoita vapfumbamwe muvanhu gumi vane WM vakapindura ibrutinib kurapwa mukutongwa muvanhu makumi matanhatu nenomwe. Uku kuyedza kwaive budiriro yakakosha yeWM sezvo iri nzira isingawanzoitika ye lymphoma uye nekudaro zvinonetsa kutora vanhu vakaringana kutora chikamu mukutongwa kwekiriniki. Uku kutongwa kwakatungamira mukubvumidzwa kweibrutinib yeWM muEurope.

 

Tinofanira Sei Kutora Ibrutinib 

Iwe uchapihwa ibrutinib semapiritsi. Inogona kupihwa pamwe chete nezvimwe zvakanangwa kurapa zvinodhaka uye chemotherapy. Panguva yekurapwa iwe unowanzoona cance¬r chiremba, mukoti wechiremba kana mukoti wezvechiremba, uye nyanzvi yemishonga. Uyu ndiye watinoreva patinotaura nezvechiremba, mukoti kana wemishonga mune iri ruzivo.

Pamberi kana pazuva rekurapwa, mukoti kana munhu akadzidziswa kutora ropa (phlebotomist) anotora muyero weropa kubva kwauri. Uku kuongorora kuti masero ako eropa ari padanho rakachengeteka kuti iwe uwane kurapwa.

Uchaona chiremba kana mukoti usati warapwa. Vachakubvunza kuti wanga uchinzwa sei. Kana zvabuda muropa rako zvakanaka, wemishonga anogadzirira kurapwa kwako. Mukoti wako anokuudza iwe apo kurapwa kwako kungangove kwakagadzirira.

Mukoti kana wemishonga achakupa mapiritsi ebrutinib ekuenda nawo kumba. Nguva dzose uzvitore chaizvo sezvakatsanangurwa. Izvi zvakakosha kuti uve nechokwadi chekuti vanoshanda pamwe nekukwanisika iwe. Unogona kupihwa mahwendefa esimba rakasiyana. Iwe unowanzo chengeta kutora ibrutinib zuva rega rega sekureba sekuchengeta kenza iri pasi pesimba. Mukoti wako kana wemishonga anogona zvakare kukupa iwe anti-chirwere zvinodhaka uye mimwe mishonga yekuenda nayo kumba. Tora mapiritsi ako ese sekutsanangurirwa kwawakaitwa.

MUTSVENE ndiye mugadziri wehunyanzvi weIbrutinib.

Ndokumbirawo ubaye pano kuti uwane ruzivo pasinaCont Cont us

 

Yeuchidzo Yeidzi pane Kuzvitarisira

Paunenge uchitora ibrutinib, inwa angangoita maviri kana matatu marita emvura maawa makumi maviri nemana, kunze kwekunge waudzwa zvimwe.

♦ Shamba maoko ako kazhinji uye mushure mekutora imwe yega bhatiyutib.

♦ Unogona kunge uri panjodzi yekutapukirwa saka edza kudzivirira vanhu kana vanhu vane dzihwa, uye utaure fever kana zvimwe zviratidzo zvehutachiona nekukurumidza kune wako wekuchengetedza hutano

♦ Kubatsira kurapa / kudzivirira maronda emumuromo uchitora ibrutinib, shandisa bhurasho remazino rakapfava, uye sukurudza katatu pazuva ne 1 teaspoon yesoda yekubheka yakasanganiswa ne8 maunzi emvura.

♦ Shandisa reza yemagetsi uye bhurasho remazino rakapfava kuti usanyanya kubuda ropa.

♦ Dzivisa kusangana mitambo kana zviitiko zvinogona kukuvadza.

♦ Kuti uderedze kusvotwa, tora mishonga yekudzivirira kusvotwa seyakarairwa nachiremba wako, uye idya zvidiki, zvinowanzoitika uchidya ibrutinib.

At Idya chikafu chinogona kubatsira kudzikisa manyoka-ona Kugadzirisa Mativi Asingaite - Dhairriya

♦ Tevedzera marongero emushonga wekudzivirira manyoka sekurairwa kwaunoitwa nevezvehutano.

♦ Dzivisa kusvibiswa nezuva. Pfeka SPF 15 (kana yakakwira) zuva block uye zvipfeko zvekudzivirira. Ibrutinib inogona kukuita kuti uwedzere kutaridzika kuzuva uye unogona kupisa zuva zviri nyore.

♦ Kazhinji, kunwa zvinwiwa zvinodhaka kunofanirwa kuchengetwa padiki kana kudzivirirwa zvachose paunenge uchitora ibrutinib. Iwe unofanirwa kukurukura izvi nachiremba wako.

Zorora zvakakwana.

Chengetedza kudya kunovaka muviri uchirapwa nebrutinib.

♦ Kana iwe ukawana zviratidzo kana mhedzisiro paunenge uchirapwa neibrutinib, ive shuwa yekukurukura nezvazvo neboka rako rezvehutano. Vanogona kupa mishonga uye / kana kupa mamwe mazano anoshanda mukugadzirisa matambudziko akadaro.

 

Ibrutinib Spano Ekukanganisa

Tsvaga rubatsiro rwezvehutano rwekukurumidzira kana iwe une zviratidzo zvehutano hunoita: mikoko; kufema kwakaoma; kurira kwechiso chako, miromo, rurimi, kana huro.

 

Rega kushandisa ibrutinib uye fonera chiremba wako kamwechete kana uine:

♦ Zviratidzo zvehutachiona- fivhiri, kutonhora, kushaya simba, maronda emuromo, kukosora nemamousu, kunetseka kufema;

♦ Zviratidzo zvekubuda ropa mukati memuviri wako - dzungu, kushaya simba, kuvhiringidzika, matambudziko nekutaura, kutemwa nemusoro kwenguva refu, zvitema kana ropa rine tsvina, weti yepingi kana shava, kana kukosora ropa kana kurutsa zvinoita kunge nzvimbo yekofi;

Di manyoka akasimba kana anoramba aripo;

Kurwadziwa pachifuva, kurova kurova kwemoyo kana kupepereka muchipfuva chako, uchinzwa kunge ungangopfuura;

Musoro wakanyanya, kuona kwakashata, kurovera mumutsipa mako kana nzeve;

Kupwanya kuri nyore, kubuda ropa kusingawanzo, pepuru kana matsvuku pasi peganda rako;

♦ Ganda rakachenuruka, maoko anotonhora nemakumbo;

Matambudziko eitsvo-kuita shoma kana kusaita weti, kuzvimba mutsoka dzako kana makumbo; kana

♦ Zviratidzo zvebundu maseru kuputsika - kuvhiringidzika, kushaya simba, mhasuru, kusvotwa, kurutsa, kukurumidza kana kunonoka kurova kwemoyo, kudzikira kuita weti, kurira mumaoko ako nemakumbo kana kutenderedza muromo wako.

 

Misungo yakajairika inogona kusanganisira:

♦ Dhairrhea, kuda kurutsa;

Fivha, kukosora, kunetseka kufema;

♦ matuza kana maronda mumuromo mako;

Tired Kunzwa kuneta;

Ru Kutuka, mapundu; kana

Pain Kurwadziwa kwemhasuru, kurwadziwa kwepfupa.

Iri haisi rondedzero yakazara yemigumisiro uye vamwe vanogona kuitika. Dana chiremba wako kune mazano ekurapa nezvemigumisiro. Iwe unogona kuudza migumisiro yakaipa kune FDA pane 1-800-FDA-1088.

MUTSVENE ndiye mugadziri wehunyanzvi weIbrutinib.

Ndokumbirawo ubaye pano kuti uwane ruzivo pasinaCont Cont us

 

Ibrutinib Storage

Chengeta Ibrutinib mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nechiedza, kupisa kwakanyanya uye hunyoro kwete muchimbuzi.

Isina kudiwa Ibrutinib inofanirwa kuraswa munzira dzakakosha kuona kuti mhuka dzinovaraidza, vana, uye nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kufuratira iyi Ibrutinib pasi pechimbuzi. Panzvimbo iyoyo, nzira yakanakisa yekurasa mishonga yako ndeye chirongwa chekudzosa-mushonga. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal ye

Zvakakosha kuchengetedza mishonga yose isingaoneki uye kusvika kune vana semiti yakawanda (yakadai sepiritsi yevhiki nevhiki uye yeavo madonhe emeso, makemikari, makanda, uye inhalers) haisi vana vasingagoneki uye vana vaduku vanogona kuvhura nyore nyore. Kuchengetedza vana vaduku kubva muchetura, nguva dzose chengetedza kuchengetedzwa kwekuchengetedza uye pakarepo ita mishonga munzvimbo yakachengeteka - imwe yakasimuka uye kure uye isati yavaona uye inosvika.

 

Reference

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[2] Byrd JC, Brown JR, O'Brien S, et al; RESONATE Vatsvagiri. Ibrutinib maringe neatatumumab mune yakamborapwa isingagumi lymphoid leukemia. N Engl J Med. 2014; 371 (3): 213-223.

[3] Byrd JC, Furman RR, Coutre SE, uye al. Makore matatu ekutevera-ekurapwa-naïve uye vakamborapwa varwere vane CLL uye SLL vanogamuchira imwechete-mumiririri ibrutinib. Ropa. 2015; 125 (16): 2497-2506.

[4] Mato AR, Chikomo BT, Lamanna N, et al. Kurongeka kwakaringana kweibrutinib, idelalisib, uye venetoclax mune isingagumi lymphocytic leukemia: mhedzisiro kubva kuongororo yakawanda yevarwere mazana matanhatu neshanu. Ann Oncol. 683; 2017 (28): 5-1050.

[5] Woyach JA, Ruppert AS, Guinn D, et al. BTKC481S-inomiririra kuramba ibrutinib mune isingagumi lymphocytic leukemia. J Clin Oncol. 2017; 35 (13): 1437-1443.

[6] Winqvist M, Asklid A, Andersson PO, et al. Chaizvoizvo-zvepasirese mhedzisiro yebrutinib mune varwere vane vakadzokazve kana kusagadzikana kusingaperi lymphocytic leukemia: data kubva ku95 vanoteedzana varwere vanorapwa muchirongwa chekushandisa chine tsitsi. Chidzidzo kubva kuSweden Chronic Lymphocytic Leukemia Group. Haematologica. 2016; 101 (12): 1573-1580.

[7] Jones JA, Hillmen P, Coutre S, uye al. Kushandiswa kweanticoagulants uye antiplatelet mune varwere vane chisingaperi lymphocytic leukemia inorapwa neyechete-mumiririri ibrutinib. Br J Haematol. 2017; 178 (2): 286-291.

[8] Kamel S, Horton L, Ysebaert L, et al. Ibrutinib inhibits collagen-mediated asi kwete ADP-yakagadziriswa platelet kuunganidzwa. Leukemia. 2015; 29 (4) 783-787.

[9] Rigg RA, Aslan JE, Healy LD, et al. Oral manejimendi yeBruton's tyrosine kinase inhibitors inokanganisa GPVI-yakagadziriswa platelet basa. Ndiri J Physiol Cell Physiol. 2016; 310 (5): C373-C380.

[10] Wang ML, Mutemo S, Martin P, et al. Targeting BTK ine ibrutinib mune yakadzokazve kana yekuratidzira mantle-cell lymphoma. N Engl J Med. 2013; 369 (6): 507-516.

[11] Treon SP, Tripsas CK, Meid K, uye al. Ibrutinib mune yakamborapa Waldenström's macroglobulinemia. N Engl J Med. 2015; 372 (15): 1430-1440.

[12] Lampson BL, Yu L, Glynn RJ, et al. Ventricular arrhythmias uye kamwe kamwe kufa kune varwere vanotora ibrutinib. Ropa. 2017; 129 (18): 2581-2584.

[13] Tedeschi A, Frustaci AM, Mazzucchelli M, Cairoli R, Montillo M. Is HBV prophylaxis inodiwa panguva yeCLL kurapwa neibrutinib? Leuk Lymphoma. 2017; 58 (12): 2966-2968.

[14] Zuva C, Tian X, Lee YS, et al. Kugadziriswa kwakasarudzika kwehumoral immune uye mashoma hutachiona muvarwere vane chisingaperi lymphocytic leukemia inorapwa neibrutinib. Ropa. 2015; 126 (19): 2213-2219.

[15] Ruchlemer R, Ben Ami R, Lachish T. Ibrutinib yechirwere cheLymphocytic leukemia. N Engl J Med. 2016; 374 (16): 1593-1594.

[16] Ahn IE, Jerussi T, Farooqui M, Tian X, Wiestner A, Gea-Banacloche J. Atypical Pneumocystis jirovecii pneumonia mune varwere vasati vambobatwa neCLL pane imwechete-mumiririri ibrutinib. Ropa. 2016; 128 (15): 1940-1943.

[17] Vitale C, Ahn IE, Sivina M, et al. Autoimmune cytopenias mune varwere vane chisingaperi lymphocytic leukemia inorapwa neibrutinib. Haematologica. 2016; 101 (6): e254-e258.

[18] Miromo GY, Pan X, Kamble S, et al. Njodzi huru yekubuda ropa pakati pevasina-valvular atrial fibrillation varwere vakatanga paapixaban, dabigatran, rivaroxaban powder kana warfarin: "chaiyo-nyika" yekuongorora kuongorora muUnited States. Int J Kliniki Dzidzira. 2016; 70 (9): 752-763.

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