J 147 powder

1. J147 Powder Video-AASraw

2. J147 Powder Basic Characters

Chii chinonzi J147 Powder?

J147 Powder is synthetic derivative ye curcumin, iyo inhengo ye curry spice turmeric. J147 Powder inonyanya kushandiswa kweCurcumin uye Cyclohexyl-Bisphenol A (CBA) iyo yose inonzi neurogenic uye neuroprotective.

J147 Powder yakaratidzwa kuvandudza zvakanyanya kukanganisa kwekuziva muvarwere vakwegura veAlzheimer. Izvi zvakawanikwa zvinoenderana neanokurumidza kuchembera mhando dzemhuka. J147 Powder mushonga wemuromo unoshanda neurotrophic unodzosera kukanganisa kwekuziva.

Curcumin inonzi polyphenol inowanikwa muturmeric uye ginger.

Curcumin ine akati wandei yakaratidza mabhenefiti mukurapa kwezvirwere zvakasiyana, zvisinei pane zvinotaridza zvisingakwanisi nekuda kwekusasimba kwayo kupfuudza Ropa-Brain Barrier (BB).

J147 Powder inogona kuyambuka BBB muuropi (yakasimba) uye inokonzera neuronal stem cell production.

J147 Powder, kusiyana nemishonga yemazuva ano yeAlzheimer's Disease, haisi acetylcholinesterase inhibitor kana phosphodiesterase inhibitor, asi inovandudza cognition nekurapa kwenguva pfupi.

Iyi nootropic iri kuwana mukurumbira sekurapa kwechirwere cheAlzheimer. J-147 Powder yakabatawo kufarira kwevashandisi vane hutano nekuda kwekugona kwayo kwekusimudzira ndangariro, kuwedzera kugona kudzidza, uye hutano hwehuropi hwese. Mushandisi anotarisa kutenga J147 Powder, anofanira kuitenga nemugadziri wepakutanga, kuitira kuti iwe uwane fekitari J-147 poda mutengo kuchengetedza mari.

J-147 inoshanda sei?

Kukanganisa kweJ-147 pamasero kwakanga kusingazivikanwe kusvikira Salk Institute neurobiologists yagadzirisa puzzles muna 2018. J-147 inoshanda nekusunga kuATP synthase. Iyi mitochondrial protein inodzora kuchembera nekugadzirisa chizvarwa chesimba remagetsi. Kuvapo kweJ-147 Powder muhurongwa hwevanhu kunodzivirira huturu hunoenderana nezera hunokonzerwa nekusashanda mitochondria uye kuwandisa kweATP.

Iyo nzira yekuita yeJ-147 Powder ichawedzerawo mazinga eeurotransmitters akasiyana-siyana akadai seNGF neBDNF. Uyezve, inoderedza mazinga e beta-amyloid, ayo anogara akakwidziridzwa muAlzheimer's uye dementia varwere. J-147 mhedzisiro inosanganisira kuderedza kufambira mberi kwechirwere cheAlzheimer, kuderedza kurasikirwa kwendangariro, uye kuwedzera neuronal cell kusikwa.

Zvidzidzo zvakawanda neJ-147 Powder zvakaitwa mumakonzo. Muedzo wevanhu wakaitwa muna 2020, zvisinei, mhedzisiro izere haisati yagovaniswa.

Benefits of J147 Upfu

①Inovandudza Mitochondrial Basa Uye Hupenyu hwehupenyu

J147 Powder inoshanda zvakanyanya pakudzikisa oxidative kusagadzikana uye kuwedzera mitochondrial performance.

Semuenzaniso, J147 Powder inowedzera mitochondrial basa nekuvandudza ATP mazinga (inhibiting ATP synthase, kunyanya ATP5A).

J147 Powder inogona kuderedza metabolites inokuvadza inotungamirira kune excitotoxicity nekudzivisa ATP synthase.

Pamusoro pehutano hwehupenyu, izvi zvinokurudzira mitochondria yakawanda yevechidiki / ine utano (nekugadzirisa nzira ye AMPK / mTOR).

② Inodzivirira Chirwere cheAlzheimer

J147 Powder inoporesa kukanganisa kwekuziva muAlzheimer's disease mice model (AD).

J147 Powder inogona kukurudzira Amyloid-Beta (A) metabolism uye kuderedza mazinga muuropi nekuderedza -Secretase protein levels (BACE).

J147 Powder inogona kudzivirira BBB permeability homeostasis uye kuvandudza vascular basa mumhando dzemhuka dzechirwere cheAlzheimer.

J147 Powder inogonawo kusimudza zvakanyanya Docosahexaenoic Acid (DHA) mazinga muuropi.

Inogona kubatsira kudzorera mazinga eGlutamate muuropi (iyo inogadzirwa kubva kuTCA yepakati -ketoglutarate).

③Kunatsiridza Memory

Inovandudza cognition mune ese Alzheimer's chirwere mbeva uye yakajairika-chembere mhuka mhando.

J147 Powder inogona kudzorera kukanganisa kwakakosha kwekunzwisisa mumhando dzemhuka dzakwegura.

J-147 inogonawo kubatsira nekuyeuka nzvimbo uye Yakareba-Term Potentiation (LTP).

④Kukura Kweuropi

J 147 Powder ine simba rekusimudzira uye kukurudzira synaptic plasticity muuropi.

J 147 Powder inokurudzira synaptic plasticity nekuchengetedza Synaptophysin kutaura (a synaptic vesicle protein inoderedzwa mune zvose kukwegura uye AD uye inonzi biomarker yekurasikirwa kwesynapse).

J-147 Powder inokurudzira kukura kwehuropi nekusimudzira mazinga eNerve Growth Factor (NGF) uye Brain-Derived Neurotrophic Factor (BDNF) (BDNF).

⑤Inodzivirira Neurons

J 147 Powder haidi kuti BDNF ive neuroprotective.

J 147 Powder inodzivirirawo neurons kubva kune glutathione (GSH) inoshaya.

J-147 Powder inodzivirira huropi kubva pakushaikwa kweglucose.

MuAD brains, 5-Lipoxygenase (5-LOX) inotora mamwe masero ekudzivirira zvirwere kuti aite mhinduro yekuputika, uye Heme Oxygenase 1 (HO-1) inoshanda sepro-oxidant pane antioxidant.

Curcumin derivative J147 Powder ine simba rekudzikisa HO-1 mazinga pamwe nekudzivisa 5-LOX.

⑥Inogona Kuvandudza Chirwere cheshuga

Mune mhando dzemhuka, J147 Powder yakaratidza kuderedza ropa Glucose uye HbA1c mazinga nekuwedzera AMPK.

Kunyange zvazvo isingakoshi, J147 Powder inogonawo kuwedzera basa remasero e-beta akasara muchirwere cheshuga.

⑦Inorwisa Marwadzo Uye Neuropathy

J-147 Powder yakaratidza kuti inoshanda mukurapa Diabetic Neuropathy mumuenzaniso wemhuka une chirwere cheshuga 1.

Inogona kubatsira kuderedza chirwere cheshuga-induced motor nerve dysfunction, peripheral sensitivity, uye marwadzo.

⑧Kugona Kuvandudza Kuzvidya Mwoyo

J147 Powder inokwanisa kuderedza mazinga ekuzvidya mwoyo.

J147 Powder yakakwanisa kuderedza kusagadzikana kwemazinga panguva yekuedzwa kwemaze mumhando dzemhuka neAD.

J147 Upfu dose uye stack

Zvidzidzo zvakasiyana zvakashandisa madosi akasiyana pamakonzo, asi chimwe chezvidzidzo zviri nani zvakapa mbeva 10 mg / kg yehuremu hwemuviri pazuva. Chimwe chidzidzo chakashandisa madosi e1, 3 kana 9 mg / kg, uye akawana mhedzisiro-inoenderana nemhedzisiro, nemadosi epamusoro achishanda zvirinani.

Nekudaro, kududzira izvi kuyero yemunhu kunoda kugadziridzwa kwenzvimbo yemuviri pamusoro. Zvinoenderana neyakajairika-shanduko fomula, munhu-akaenzana muyero anofanirwa kuenzana muyero wegonzo wakakamurwa ne12.3-kana .81 mg pa kg yehuremu hwemuviri pazuva.

Mamwe mabhenefiti anozoonekwa kana wangotanga kuishandisa. Kunyangwe nekurapa kwenguva pfupi, J-147 inokurudzira kukurumidza antidepressant-semhedzisiro mumakonzo pamusoro penguva ye3-zuva pasina kumisikidza kushivirira kwezvinodhaka kana kuwedzera cognition. Kune akawanda J147 Powder inotengeswa pamhepo, zvakakosha kutenga chaiyo uye yemhando yepamusoro chigadzirwa. Unogona kutenga J147 Powder Wholesale nemutengesi AASRAW.

J147 haisati yave yakakurumbira pakati pevanhu vane hutano kwenguva yakareba zvakakwana kuti isu titaure nechivimbo chero zvimedu. Haasi ese nootropics anogona 'kusanganiswa uye anoenderana' zvakachengeteka.

J147 Upfu human trials and uwater experiences

Yekutanga J147 Powder yekudzidza kwevanhu yakanyoreswa uye inotarisirwa kupedzwa muna 2020. Inoratidzika kunge yakaitwa sechikamu chekuedza 1 kune 64 vanhu vane hutano, nechinangwa chekutanga chekuongorora kuchengetedzwa uye pharmacokinetics (hafu yeupenyu, rutivi. migumisiro, kusungirirwa kwenyama) yeJ147 Powder, panzvimbo yekubatsira kwayo mukurapa chero mamiriro ezvinhu.

Kunyange hazvo zvakabuda muongororo iyi zvisati zvaburitswa pachena, tinoziva kuti zvakaratidza kuti zvakapedzwa pasina matambudziko akakura.

Kunyangwe J147 Powder ikemikari yekutsvagisa uye yakakurukurwa munharaunda dzinoverengeka dzenootropics, hapana mishumo yakawanda yevashandisi yakapihwa kusvika zvino, uye vanhu vazhinji vakamirira kuona kumwe kudzidza vasati vaishandisa. Maererano nevashandisi veJ-147 Powder, Zviri nyore kutenga J147 powder online, kuwana chaiyo J147 Powder supplier ichapedza dzimwe nguva. AASRAW mutengesi anopa mhando yepamusoro J-147 Powder. Kana iwe ukaita J-147 zvinowedzera, unogona kutenga J147 Powder yakawanda kuti unakidzwe nemutengo wakanaka.

Ruzhinji rwevanhu vanoita sevasingaone mhedzisiro kubva kune mashoma evashandisi zviitiko zvataurwa. Kunyange zvazvo vashandisi vanowanzove vaduku uye vane hutano uye nguva yekushandiswa inowanzopfupika kudarika muzvidzidzo, curcumin derivative J147 Powder inogona kunge isina kunyanya kukosha nootropic migumisiro kune vechidiki vane hutano.

Tinogona kungoita fungidziro dzakadzidziswa dzekuti J147 Powder ingave inobatsira sei mukusavapo kwetsvakiridzo yevanhu kana anecdotes akakurumbira. Muchidzidzo, chero chinhu chinowedzera neuronal simba metabolism chinofanirwa kunge chine nootropic mhedzisiro, zvisinei basa rako rekuziva rinogona kunge risiri kuganhurirwa nekushandiswa kwesimba. Zvinogona kuenderana nekuti zvinovaka muviri zvinogona kukurumidza sei kupinda nekubuda muuropi hwako kana kuti pfungwa dzako dzakaiswa pamwechete zvakanaka sei.

Curcumin derivative J147 Powder inogadzirawo zvimwe zvakawanda zveurotrophic, zvinoreva kuti inogona kubatsira uropi hwako kugadzira mamwe masinapsesi uye masero ehuropi. Asi ramba uchifunga kuti panogona kuve nekuwanda kwe synapses uye masero ehuropi.

Ikozvino hapana chikonzero chekutenda kuti J147 Powder ichava nehuwandu hwenootropic kune vechidiki, vanhu vakuru vane utano. Kune avo vane dementia, zvinonyanya kubatsira. Muvanhu vakura zvishoma vanoziva kuti dementia inofamba mumhuri yavo, inogona kubatsira seanotropic sezvo inogona kumira kana kudzorera kurasikirwa kwenjere isati yatanga muchipatara dementia. Chero zvazvingava, zvichatora nguva tisati tive nechokwadi.

J-147 Upfu risk uye spano ekukanganisa

J147 Powder yakaongororwa nekliniki uye yakawanikwa yakachengeteka kushandiswa kwenguva refu nemalabhu akazvimiririra. Yakapfuura toxicological kuyedzwa muzvidzidzo zvemhuka izvo Food and Drug Administration (FDA) inoda, uye hapana mhedzisiro yakanyorwa muvanhu kana yakatorwa painokurudzirwa dosi (yakazokurukurwa gare gare).

apo kutenga J-147 Powder?

Kutendeseka kweiyi nootropic kuchiri kukakavadzana, zvisinei hazvizokutadzisi kutenga zvinhu zviri pamutemo. Mushure mezvose, miedzo yekiriniki yeJ-147 Alzheimer yatove kuenderera. Unogona kutenga hupfu kubva kuzvitoro zvepamhepo sezvo uchikwanisa kuenzanisa J-147 Powder mitengo kubva kune vakawanda vatengesi. Nekudaro, iwe unofanirwa kutarisa-tarisa kune ane mukurumbira mugadziri ane yakazvimirira murabhoritari kuyedzwa.

Kana iwe uchida imwe J-147 Powder inotengeswa, tarisa nefekitari yedu. Isu tinopa huwandu hwakawanda hwenootropics pasi pekutonga kwakasimba kwemhando. Zvichienderana nechinangwa chako che psychonautic, unogona kutenga muhuwandu kana wega. Ziva kuti, J-147 Powder mutengo une hushamwari chete kana iwe uchinge watenga muhuwandu hwakawanda.

J147 Powder Testing Report-HNMR

Chii chinonzi HNMR uye HNMR spectrum inokuudza chii? H Nuclear Magnetic Resonance (NMR) spectroscopy inzira yekuongorora chemistry inoshandiswa mukudzora kwemhando uye tsvagiridzo yekuona zvirimo uye kuchena kwesample pamwe nemaitiro ayo mamorekuru. Semuyenzaniso, NMR inokwanisa kuongorora musanganiswa ane zvinozivikanwa makomboni. Kumakomisheni asingazivikanwe, NMR inogona kushandiswa kuenzanisa nekuona maraibhurari kana kufembera iyo yakakosha chimiro zvakananga. Kana iyo yekutanga dhizaini yazivikanwa, NMR inogona kushandiswa kuona mamolecular conformation mumhinduro pamwe nekudzidza zvimiro zvemuviri padanho remamorekuru senge conformational exchange, shanduko yechikamu, solubility, uye diffusion.

J-147 Powder(1146963-51-0)-COA

J-147(1146963-51-0)-COA

Nzira yekutenga J147 Powder kubva kuAASraw?

❶Kutibata nesu neemail yekubvunza sisitimu, kana kutisiya nhamba yako yewhatsapp kwatiri, mumiriri wedu wevatengi (CSR) achabata newe mumaawa gumi nemaviri.

❷Kutipa huwandu hwako hwekubvunza uye kero.

❸Yedu CSR ichakupa iyo quotation, nguva yekubhadhara, nhamba yekutevera, nzira dzekutumira uye inofungidzirwa zuva rekusvika (ETA).

❹Kubhadhara kwaitwa uye zvinhu zvinotumirwa mumaawa gumi nemaviri.

❺Zvinhu zvakagamuchirwa uye kupa mhinduro.

References

[1] Pan X, Chen L, Xu W, Bao S, Wang J, Cui X, Gao S, Liu K, Avasthi S, Zhang M, Chen R. “Kuitwa kwe monoaminergic system kunobatsira kune antidepressant- uye anxiolytic-like migumisiro yeJ147." Behav Brain Res. 2021 Aug 6;411:113374. doi: 10.1016/j.bbr.2021.113374. Epub 2021 Chivabvu 21. PMID: 34023306

[2] Li J, Chen L, Li G, Chen X, Hu S, Zheng L, Luria V, Lv J, Sun Y, Xu Y, Yu Y. "Sub-Acute Treatment yeCurcumin Derivative J147 Inogadzirisa Kuora Mwoyo-Kufanana Nemaitiro Kuburikidza ne5-HT1A-Mediated cAMP Signaling. "Front Neurosci. 2020 Jul 8;14:701. doi: 10.3389/fnins.2020.00701. eCollection 2020.PMID: 32733195

[3] Jin R, Wang M, Zhong W, Kissinger CR, Villafranca JE, Li G. "J147 Inoderedza tPA-Induced Brain Hemorrhage muAcute Experimental Stroke mumakonzo."Front Neurol. 2022 Mar 2;13:821082. doi: 10.3389/fneur.2022.821082. eCollection 2022. PMID: 35309561

[4] Emmanuel IA, Olotu FA, Agoni C, Soliman MES. "MuSilico Repurposing yeJ147 yeNeonatal Encephalopathy Kurapa: Kuongorora Molecular Mechanisms yeMutant Mitochondrial ATP Synthase." Curr Pharm Biotechnol. 2020;21(14):1551-1566. doi: 10.2174/1389201021666200628152246. PMID: 32598251

[5] Lian L, Xu Y, Zhang J, Yu Y, Zhu N, Guan X, Huang H, Chen R, Chen J, Shi G, Pan J. "Antidepressant-semigumisiro yeinoveli curcumin derivative J147: Kubatanidzwa kwe 5-HT1A receptor." Neuropharmacology. 2018 Jun;135:506-513. doi: 10.1016/j.neuropharm.2018.04.003. Epub 2018 Kubvumbi 5. PMID: 29626566

Wana Bulk quotation