Urolithin Upfu

1.Urolithin A Backgroud

Mabhenefiti emoyo mabhenefiti akatungamira vaongorori kuti vaongorore munzira dzipi idzi chibereko chitsvuku chinogona kutichengeta takagwinya. Mukutsvaga kwazvino, vatsvagiri veSwitzerland vakaona mamorekuru matsva anokonzerwa nekugaya makomponi maviri anowanikwa mumatamba: punicalagins uye ellagitannins. Iyi mamorekuru akasarudzika, anozivikanwa seurolithin A, anobatsira kumutsidzira mitochondria, dzimba dzemagetsi dzemagetsi. Urolithin A inovhura musuwo kune ingangodaro nyowani yekurapa kurwisa zvinopesana nezera, kusanganisira kushaya simba, inova njodzi yekuremara, kurapwa muzvipatara nekufa.

2.Urolithin A Overview

Urolithin A chinhu chemetabolite, iri yekirasi yemakemikari anozivikanwa se benzo-coumarins. Ndicho chigadzirwa chekupedzisira chinogadzirwa kubva mukudyiwa kwechikafu chine ellagitannins (polyphenols) uye inogadziriswa nehutumbi hwomuviri. Mune mamwe mazwi, Urolithin A inogadzirwa kana munhu akamedza chikafu chine ellagitannins.

Urolithin A haina kuitika zvakasikwa mugumo fomu. Ellagitannin chikafu masosi, senge mamwe marudzi amajiki uye pomegranate, inofanirwa kuve inogadziriswa nematumbu mabhakitiriya kuti agadzirwe. Kuti mukomboni iyi ive nemaapplication anoshanda, inofanirwa kugadzirwa murabhoritari, kana nemamwe mazwi, Urolithin A yekugadzira inofanirwa kugadzirwa kuitira kuti ishandiswe.

3.Urolithin A Mechanism of Action

Urolithin A inoshanda sei? Ellagic acids uye Ellagitannins ndiUrolithin A anotungamira.

Ellagitannins akaiswa hydrolyzed kubva mudumbu kuti isunungure Ellagic acid, uye izvi zvinogadziriswa kubva mudumbu microflora kuenda kuurolithins kuburikidza nekuwedzera kurasikirwa mune 1 yemaviri ayo lactones anoteedzana kubviswa kwemapoka ehydroxyl. Kana Angopedzwa mumatumbo, ipapo Urolithin A poda inopinda inoyerera Sisitimu yemukati ura.

Mitophagy, sekureva kweWikipedia tsananguro, ndiko kuora kwekusarudzika kwemitochondria yako nekuzvipira. Iyo inowanzoitika kune isina kukwana mitochondria inotevera kukuvara kana kushushikana. Nekudaro, isu sezvatinokwegura, Mitophagy basa rinova risinganyatsoshanda. Neraki, Urolithin A inogamuchirwa kukurudzira mitophagy nenzira yakachengetedzwa pamarudzi akasiyana siyana.

4.Benefits/Effects yeUrolithin A

❶ Urolithin A Inobatsira Kurwisa Gomarara

Kunyangwe paine hukasha hwekuvhiya uye chemotherapy, vangangoita makumi mashanu muzana yevanhu vane macancer echirwere ichi vanogadzira mamota anodzokororwa. Izvi zvinogona kuve zvichikonzerwa nechikamu kupona kweanotyisa colon-cancer maseru maseru anodzivirira akajairwa chemotherapy uye anoita se `` mbeu '' kune anotevera cancer.
Mukutsvaga kunonakidza, vaongorori vakafumura maseru emukenza-kenza maseru kubva kumurwere ane gomarara rakajeka kune chero musanganiswa une 85% urolithin A kana 30% urolithin A. Mhedzisiro yacho yainakidza. Iyo yepamusoro urolithin Musanganiswa wevasungwa wainyanya kushanda pakudzivirira huwandu uye saizi yekoloni-kenza maseru maseru uye ichidzivirira chiitiko chealdehyde dehydrogenase, mucherechedzo wechemoresistance.

❷ Urolithin A - Neuroprotective Effects

Iko kubatana pakati pambagranate uye yayo neuroprotective mhedzisiro kurwisa chirwere cheAlzheimer chave chakasimbiswa muzvidzidzo zvemhuka.8 Zvisinei, izvo bioactive zvinoumba zveichi chiito zvaisazivikanwa kusvika zvino.
Chirwere cheAlzheimer chinotarisirwa kubata vanhu vanopfuura mamirioni zana nemakumi masere neguru pasirese pagore ra115. Boka revatsvakurudzi rakatarisa ongororo yemhuka yapfuura iyo yakataura pamusoro pezvekurwisa-Alzheimer mhedzisiro yematamba anowanikwa.
Chikwata chakaongorora kugona kwezvikamu izvi kuyambuka ropa-huropi chinodzivirira uye chakaona kuti methylated fomu yeurolithin A (mUA), yakatorwa kubva pomegranate, pamwe nemamwe maurolithin aikwanisa kuzviita.
Uye, kunyangwe hazvo kutsvagurudza kuchidikanwa, vanyori vakapedzisa kuti urolithin ndiwo makomponi anokwanisa anokonzeresa kurwisa-Alzheimer mhedzisiro inosanganisira kudzivirira kubva neurotoxicity uye b-amyloid fibrillation. Mhedzisiro iyi iri kuvimbisa, uye inoratidza kudiwa kwekutarisa dzimwe nzira dzechinyakare-dzakavakirwa pakudya nzira dzekudzivirira kana kudzikisira kufambira mberi kweAlzheimer's.
Mhedzisiro uye data kubva kune izvi zvakasiyana zvidzidzo zvinowedzera kutsigira kukosha kwe polyphenol metabolite macomputer senge urolithin A kubva pomegranate uye nebasa ravo pakurwisa kenza yekoloni uye neurodegenerative hosha.
Zvidzidzo zvakare zvakaratidza kuti Urolithin A inogona kusimudzira mhasuru simba uye kutsungirira muvanhu vanokwegura. Ongororo ichangoburwa inoratidza kuti humbowo hwepakutanga hunopa zvimwe zvakanaka zveUrolithin A, zvinosanganisira zvinotevera:

-Anti-kuzvimba
-Anticarcinogenic
-Antioxidant
-Anopokana
-Antimicrobial

Urolithin A inoonekwawo zvakanyanya sekuwedzera kune zvigadzirwa zveproteinini kuti zviwedzere mhedzisiro yekurovedza muviri, pamwe nekuderedza kufutisa.

5.Urolithin A Side Effects

Mune zvakataurwa pamusoro apa zvekuongororwa kwevanhu, hapana mhedzisiro yakaipa yakataurwa. Mukuferefeta pamusoro pechikamu chakateedzana uye zvekuchipatara zvidzidzo, zvinoita kunge paine humbowo hwekutsigira kuchengetedzeka kweUrolithin A kushandiswa.

Hapana mhedzisiro yehutachiona yakataurwa, kunyangwe muzvidzidzo zvaisanganisira iro rakanyanya mwero rakapihwa makonzo muzvidzidzo zvakadaro.

6.Urolithin A Food Sources

Sezvambotaurwa, Urolithin A mune yayo yekupedzisira fomu hairatidzike zvakasununguka. Hazvizivikanwe kuwanikwa mune chero chikafu chikafu. Nekudaro, iyo inotungamira kune iyo komponi inogona kuwanikwa mune mimwe michero nenzungu. Zvekudya zvinyorwa zvine ellagitannins senge pomegranate, raspberries, mastrawberry, cloudberries, uye walnuts mimwe mimwe mienzaniso.

Iyo ellagitannins iri mune iyi michero uye nzungu yakaiswa hydrolyzed mudumbu kuti ibudise ellagic acid, iyo inozoenderera mberi kugadziriswa mumatumbu uye kugadziriswa nematumbu microflora muUrolithin A.

Izvo zvakakosha kuti uzive kuti Urolithin A haiwanzo kuitika kana ichimwa. Humwe huturu hwevanhu hauna musanganiswa wakanaka we microflora inodiwa kushandura ellagic acid kuita Urolithin A. Izvi zvinoreva kuti havazi vese vanozogadzira Urolithin A mumatumbu avo kana vakadya pomegranate, walnuts, kana ma berries. Izvo zvese zvinoenderana nematumbu mabhakitiriya aripo mumuviri wako.

7.Urolithin A Manufacturing Process

Urolithin A inogadzirwa kuburikidza nemakemikari syntheses uchishandisa imwe yeaya maviri maitiro akatsanangurwa pazasi. Maitiro ese ari maviri anosanganisira Ullmann coupling reaction, inoteverwa neLewis acid kurapwa kuti ibudise yakanatswa kwazvo urolithin A chigadzirwa.

Chigadzirwa chekupedzisira chinonatswa nenzira dzakajairika dzekurapa muzvinyungudutswa, zvinosvinwa, kuwachwa, uye kuomeswa kuwana yakachena urolithin A. Chigadzirwa chinozoiswa pasi pechekuru saizi.

Zvinoenderana nemaitiro akasimbiswa, Urolithin A poda inogadzirwa uye inocheneswa mumatanho akakosha akati wandei kune 99% yakachena. Mbishi Zvishandiso uye matanho ekugadzirisa anobatanidzwa mukutanga kweiyo urolithin A inosanganisira 2-Bromo-5-methoxy benzoic acid, 2-Bromo-5-hydroxy benzoic acid, Resorcinol, 50% sodium hydroxide, Copper sulfate pentahydrate, Methanol, Aluminium chloride, Toluene , DMSO, Methanol, Acetic Acid, uye TBME (tert-butyl-methyl ether).

8.Synthetic Urolithin A VS Natural Urolithin A

Sezvambotaurwa pamusoro apa, Urolithin A iguta-rinotora hutachiona hwemetabolite yeellagitannins (ET) kana ellagic acid (EA). Kana iwe uchida kuwana yakawanda kwazvo yeUrolithin A, iwe unofanirwa kutanga wadya michero yakawanda, uye wozovamirira kuti vatamire kubva kune ellagitannins uye ellagic acid kuenda kuUrolithin A. Maitiro aya akareba, uye kuchena kwaro kwakaderera, uye zvakanyanya kukosha , zvinodhura zvakanyanya kuita kudaro.

Haasi munhu wese ane microflora chaiyo inogona kuita iyo metabolite. Uye zvakare, maitiro aya haatombo shandiswa mukugadzira kwakawanda munzvimbo yeGMP-inoenderana yekugadzira.

Nhau dzakanaka ndedzekuti, sechinhu chitsva, Urolithin A inozopedzisira yawanikwa nekutengesa mu2019 kubva kuCima Science. Ikozvino inogona kugadzirwa murab uye fekitori. Iyo synthetic urolithin A yakafanana muchimiro neiyo yakasarudzika urolithin A. Kugona kugona kunosvika 3000 kgs kana 2.5 matani / mwedzi.

9.Urolithin A Kuchengetedza

Urolithin A inogamuchirwa neEuropean Union sechinhu chinowanikwa mune zvekudya.

IU.S. Food and Drug Administration (FDA) muna 2018 yakapa urolithin A mamiriro ayo GRAS anoshandiswa mukudya kwekuwedzera fomura. GRAS zvinoreva kuti Urolithin A inowanzoonekwa seyakachengeteka ine muyero we500mg kusvika 1 gramu pakushanda.

Urolithin Kuchengetedzwa kwakatsvagiswa pamatanho epamberi uye ekuongororwa emakiriniki, ayo anokurudzira kuchengetedzeka kwehutano pane zvaanoda kushandisa. Kudzokororwa muyero 28-zuva uye 90-mazuva zvidzidzo zveurolithin A mumakonzo hazvina kuratidza chero huturu hwehuturu mune mamwe ma parameter akayerwa munzira ipi neipi doses yakaedzwa.

10.Welcome To buy Urolithin A/Urolithin A 8-Methyl Ether Bulk Powder kubva kuAASraw!

Kuwanikwa kweurolithin A, iyo inoguma kubva punicalagins uye ellagitannins makemikari anowanikwa mumatamba, inopa mikana mitsva yekurwisa kudzika-zvine chekuita nezera remitochondrial basa uye kunokonzera kushaya simba uye kurasikirwa kwetsandanyama.

Nekubatsira maseru kuzvimutsiridza uye nekuvandudza mashandiro emhasuru, mutamba wedamba uye ayo achangobva kuzivikanwa metabolism, urolithin A-inogona kuratidza kubudirira.

Pamwe pamwe nezvakawanikwa izvi, pane humbowo hunotsigira hweakasimba mhedzisiro urolithin A inopesana nechirwere cheAlzheimer nekenza, ichipa imwezve chishandiso chekurwisa aya mamiriro anoparadza anokanganisa vanhu vazhinji vakwegura.

Iyi nzira yehutano inovhura mikana iyo nzira dzechinyakare dzemishonga dzisati dzamboongorora. Kana iwe uchida kutenga Urolithin A poda / Urolithin A 8-Methyl Ether powder, AASraw pamwe sarudzo yakanaka.

11.Urolithin A VS Urolithin B

Ose ari maviri Urolithin B uye Urolithin A poda anoshandiswa mukuwedzera, asi ane akasiyana anoshanda mabhenefiti. Vanoshanda neimwe nzira yekuita. Urolithin A inonyanya kuve yeAnti-kuchembera formula yeiyo mitophagy mechanism nepo urolithin B iri mune yemitambo chikafu chefodya sechinhu chinovaka mhasuru.

Urolithin A musanganiswa wakanyatso tsvakurudzwa, wagara uchionekwa seakachengeteka (GRAS) neFDA, nepo urolithin B isiri. Kune mamwe marudzi ekuwedzera anoshandisa urolithin A pane urolithin B.

Urolithin A uye Urolithin B zvakavharwa zvine hukama. Pomegranate extract ine ese ari maviri aya urolithin. Mapomegraneti ndiwo muchero wemuchero. Mushure mekugaya, zvikamu zvadzo zvinokwanisa kushandurwa nemaruva emudumbu kuita urolithin C uyezve kushandurwa kuita Urolithin D uye A, uyezve Urolithin B. Mupfungwa iyi, urolithin A inogona kushandurwa kuita urolithin B.

Nokudaro, zvishoma zveurolithin B zvinogona kuwanikwa muropa revanhu vanodyiswa nedamba repomegranate; zvisinei, iyo antioxidant uye anti-inflammatory properties inenge isina simba kudarika urolithin A. Zvisinei, urolithin B ine mukana wayo pachayo pane urolithin A. Inokwanisa kuwedzera masero emhasuru uye kukurumidza kukura kwemhasuru.

12.Urolithin B Tsanangudzo

Urolithin B iyi urolithin, mhando yezvakakomberedzwa zvinogadzirwa muguchu remunhu mushure mekupinza ellagitannins-ine chikafu senge pomegranate, foshoro, tsvuku raspberries, walnuts kana oak-zera waini tsvuku. Urolithin B inowanikwa mune urini mune fomu yeurolithin B glucuronide.

Urolithin B zvakare chigadzirwa chechisikigo chine antiproliferative uye antioxidant chiitiko. Urolithin B inoumbwa nemetabolism kubva kune polyphenols inowanikwa mune mamwe marimu nemichero, kunyanya matamba. Urolithin B yakaratidzirwa kuyambuka iyo brain brain barrier, uye inogona kuve neuroprotective mhedzisiro kurwisa Alzheimer's Chirwere.

13.Urolithin B Mechanism of Action

Iyo inoderedza mapuroteni kudzikisira uye inokonzeresa mhasuru hypertrophy. Urolithin B inodzivisa chiitiko chearomatase, enzyme inoshandura estrogen uye testosterone.

Urolithin B chigadzirwa chechisikigo chine antiproliferative uye antioxidant chiitiko. Urolithin B inoumbwa nemetabolism kubva kune polyphenols inowanikwa mune mamwe marimu nemichero, kunyanya matamba. Urolithin B yakaratidzirwa kuyambuka iyo brain brain barrier, uye inogona kuve neuroprotective mhedzisiro kurwisa Alzheimer's Chirwere.

14.Urolithin B Kushandisa

Ndichiri kudzidza anti-kupisa uye antioxidant zvimiro zveurolithins A uye B, vaongorori veUCL zvakaitika kuti vaone kuti iyo yekupedzisira yaive nedziviriro pamhasuru. 'Maseru maseru mutsika aive akabatana neurolithin B akave akakura pane aya anga asiri. Taida kuziva kuti sei.

Kutanga, ivo vakafunda izvo zvinhu mu vitro uye vakawana urolithin B ine hunyambiri maitiro: iyo inomutsa mhasuru protein synthesis uye inononoka kudzikisira.

Chechipiri, vaongorori vakafunda zvinoitika zveurolithin B mu vivo, pamakonzo. 'Yakawedzera kukura kwavo kwemhasuru', Prof. Francaux anodaro. 'Isu takaipawo mbeva nemhasuru yakadamburwa inokonzeresa kuoma mitezo, uye kurasikirwa kwemasuru kwakatevera kwakaitika 20 kusvika 30% zvishoma nekukurumidza uye padiki padiki.'

15. Migumisiro yeUrolithin B

Urolithin B ndeimwe yematumbo microbial metabolites eellagitannins, uye ine anti-kupisa uye antioxidant mhedzisiro. Urolithin B inodzivisa chiitiko cheNF-κB nekudzikisa phosphorylation uye kudzikisira kweI VerBcy, uye inodzvinyirira iyo phosphorylation yeJNK, ERK, neAkt, uye inosimudzira phosphorylation ye AMPK. Urolithin B iri zvakare mutongi wemabhonzo emhasuru.

(1). Urolithin B inoderedza kurasikirwa kwemhasuru uremu hunokonzerwa neiyo denervation
(2). Urolithin B-inosimudzira masaga mhasuru hypertrophy mumakonzo
(3). Iyo anabolic mhedzisiro yeurolithin B inopindirana neye androgen receptor
(4). Urolithin B inomutsa protein synthesis muC2C12 myotubes nekumisikidza mTORC1 siginecha
(5). Urolithin B inodzivisa kuwora kweprotein nekudzora ubiquitin-proteasome nzira
(6). Urolithin B inowedzera kusiyanisa kweC2C12 myotubes

Reference

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